The Trypanosomatid Genomes: Science Online Special Collection

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In its 15 July 2005 issue, Science Magazine publishes an exploration of the genome sequences of the three so-called Tritryp parasites -- Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major -- as well as additional studies and articles shedding further light on the biology of these three notorious parasites. The journal's online companion Signal Transduction Knowledge Environment further investigates with a Perspective on host-cell signaling and T. cruzi invasion.

INTRODUCTION

Trypanosomatid Genomes
C. Ash and B. R. Jasny

VIEWPOINT

Health Innovation Networks to Help Developing Countries Address Neglected Diseases
C. M. Morel et al.

RESEARCH ARTICLES

Comparative Genomics of Trypanosomatid Parasitic Protozoa
N. M. El-Sayed et al.

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease
N. M. El-Sayed et al.

The Genome of the African Trypanosome Trypanosoma brucei
M. Berriman et al.

The Trypanosomatid Genomes: Plates

The Genome of the Kinetoplastid Parasite, Leishmania major
A. C. Ivens et al.

Also of related interest in this issue:

Editorial: Trypanosomes at the Gates
G. A. M. Cross

Report: Apolipoprotein L-I Promotes Trypanosome Lysis by Forming Pores in Lysosomal Membranes
D. Pérez-Morga et al.

Report: The Trypanosoma cruzi Proteome
J. A. Atwood III et al.

PERSPECTIVE

Host Cell Signaling and Trypanosoma cruzi Invasion -- Do All Roads Lead to Lysosomes?
B. A. Burleigh: Investigation of the role of PI3K signaling suggests that T. cruzi entry into host cells may be lysosome-independent.

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