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Special Online Collection: The Nucleus

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The NucleusIn the 30 November 2007 issue, Science and its online companion Signal Transduction Knowledge Environment (STKE) explore the organization and dynamics of the cell nucleus, which not only houses the genetic material of an organism, but also undergoes dramatic physical transformations during each cell cycle. In Science, a News story discusses efforts to define the spindle matrix -- a hypothetical structure that may help a dividing cell move its chromosomes -- while three Review articles describe the impact of new proteomics and imaging technologies on our understanding of nuclear dynamics, the complex roles of the nuclear envelope, and the regulation of nucleocytoplasmic transport. In STKE, two Perspectives highlight mechanisms controlling the nuclear transport of the growth hormone receptor and of p53 after DNA damage.

In Science

INTRODUCTION

Journey to the Center of the Cell >
Stella M. Hurtley, Elizabeth Pennisi

NEWS

Return of the Matrix >
John Travis

REVIEWS

Toward a High-Resolution View of Nuclear Dynamics >
Laura Trinkle-Mulcahy, Angus I. Lamond
Blurring the Boundary: The Nuclear Envelope Extends Its Reach >
Colin L. Stewart, Kyle J. Roux, Brian Burke
Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport >
Laura J. Terry, Eric B. Shows, Susan R. Wente

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Focus Issue: Mastering Nuclear Dynamics >
Nancy R. Gough
The nucleus is connected to cytoplasmic signaling networks and has its own complex signaling environment.

PERSPECTIVE

Genomic Maintenance: The p53 Poly(ADP-ribosyl)ation Connection >
Rafael Alvarez-Gonzalez
In response to DNA damage, p53 is modified by poly(ADP-ribose) polymerase-1 (PARP-1) and accumulates in the nucleus.

PERSPECTIVE

Nuclear Localization of Growth Hormone Receptor: Another Age of Discovery for Cytokine Action? >
Steven M. Swanson and John J. Kopchick
Translocation of the growth hormone receptor to the nucleus is linked with tumorigenesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)