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In the 10 April 2009 issue, Science highlights advances in our understanding of protein dynamics. Review and Perspective articles explore how the dynamic properties of proteins enable them to mediate complex signaling tasks, protein evolvability, how cell-cell and cell-matrix protein interactions contribute to tissue formation and homeostasis, and the use of nuclear magnetic resonance spectroscopy in drug discovery and design. In the 14 April issue of Science Signaling, articles and a presentation highlight mechanisms by which subcellular protein trafficking can influence cellular behavior, conformational changes in G protein–coupled receptor signaling, how pathogens exploit host protein interactions to their advantage, and allosteric regulation in immune cell signaling.
In Science
In Science Signaling
EDITORIAL GUIDE
- Focus Issue: The Protein Dynamics of Cell Signaling
- Wei Wong and Nancy R. Gough
Changes in the conformation, binding partners, or localization of signaling proteins affect the flow of information through signaling cascades.
RESEARCH ARTICLE
- Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos
- Philippe-Alexandre Pouille, Padra Ahmadi, Anne-Christine Brunet, Emmanuel Farge
Mesoderm invagination during gastrulation is controlled by mechanical cues that promote Fog signaling and redistribution of a motor protein.
PRESENTATION
- Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes
- Arup K. Chakraborty, Jayajit Das, Julie Zikherman, Ming Yang, Christopher C. Govern, Mary Ho, Arthur Weiss, Jeroen Roose
Simulations, theory, and experiments reveal a potential molecular mechanism for digital signaling and short-term molecular memory in lymphocytes.
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PERSPECTIVES
- Arrestin Times for Developing Antipsychotics and β-Blockers
- Miles D. Houslay
Conformation determines G protein–independent signaling through β-arrestins.
- HIV Infection of T Cells: Actin-in and Actin-out
- Yin Liu, Natalya V. Belkina, Stephen Shaw
The coordinated activities of various actin-binding proteins facilitate entry of HIV into T cells.
MEETING REPORT
- Visualizing Immune System Complexity
- Michael L. Dustin
From individual molecules to cells in vitro to cells in animals, imaging has brought incredible insight to immunology.
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