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Immunotherapy

Jump to Features in
This Special Collection:

In Science Magazine
In Science's STKE
In Science's SAGE KE
In a special collection of articles published 9 July 2004, Science Magazine and several of its online companion sites review progress and challenges in the field of immunotherapy, which harnesses the power of the immune system in the struggle against a range of diseases. In Science, News, Viewpoint, and Review articles cover immunotherapy's prospects in treating cancer and chronic infectious diseases -- as well as the challenges involved in "putting the brakes on" the immune system in fighting transplant rejection and autoimmune disorders. The Signal Transduction Knowledge Environment features a range of articles on the signaling pathways regulating immune tolerance and the molecular mechanisms of antibody immunotherapy. And the Science of Aging Knowledge Environment considers several angles on the efficacy of vaccination in aging populations and age-related disorders.

 

In Science

INTRODUCTION

Two Sides of a Coin
S. J. Simpson and E. Marshall

NEWS
Putting Tolerance to the Test
J. Couzin

VIEWPOINTS AND REVIEWS

Immunotherapy: Bewitched, Bothered, and Bewildered No More
R. M. Steinman and I. Mellman

Cancer Immunotherapy: A Treatment for the Masses
J. N. Blattman and P. D. Greenberg

Therapeutic Vaccines for Chronic Infections
B. Autran, G. Carcelain, B. Combadiere, P. Debre

In STKE
EDITORIAL GUIDE

Focus Issue--Tailoring the Immune Response
E. M. Adler
Enhancing or inhibiting the immune response is the goal of immunotherapy.
PERSPECTIVES
Using Signaling Pathways to Overcome Immune Tolerance to Tumors
E. G. Engleman, J. Brody, L. Soares
Can stimulation of dendritic cells with toll-like receptor ligands overcome tolerance to tumor antigens?
PERSPECTIVES
E3 Ligases in T Cell Anergy--Turning Immune Responses into Tolerance
V. Heissmeyer and A. Rao
Protein degradation destabilizes the immune synapse in anergic T cells.
Empowering Targeted Therapy--Lessons from Rituximab
A. J. Olszewski and M. L. Grossbard
A monoclonal antibody used in treating lymphoma may elicit cell death through multiple mechanisms.

In Science's SAGE KE


PERSPECTIVE
Immunotherapy for Alzheimer's Disease
P. L. McGeer and E. McGeer
Can a vaccine thwart this neurodegenerative disorder?


NEWS SYNTHESIS
All Pain, No Gain
M. Leslie
Shots in the elderly often miss their target, but researchers are starting to learn why.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)