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Special Online Collection: Challenges in Immunology

Jump to features in special collection:

Challenges in ImmunologyIn the 3 August 2007 issue, Science and its online companion Signal Transduction Knowledge Environment (STKE) join forces to explore some the outstanding challenges in the field of immunology. In Science, a collection of Perspective articles highlights topics of active research from human primary immunodeficienies to lymphocyte function and development, while two News stories describe efforts to thwart HIV using gene therapy and to unlock the mysteries of mast cells. In STKE, Review and Perspective articles discuss the signals involved in controlling T cell fate, T cell responsiveness, and the response to cytokines secreted by T cells.

In Science

INTRODUCTION

Testing Our Defenses >
S. J. Simpson and J. Travis

NEWS

Building an HIV-Proof Immune System >
J. Cohen
Mast Cells Show Their Might >
M. Leslie

PERSPECTIVES

Primary Immunodeficiencies: A Field in Its Infancy >
J.-L. Casanova and L. Abel
Epigenetic Flexibility Underlying Lineage Choices in the Adaptive Immune System >
D. Kioussis and K. Georgopoulos
Division of Labor with a Workforce of One: Challenges in Specifying Effector and Memory T Cell Fate >
S. L. Reiner, F. Sallusto, A. Lanzavecchia
Private Lives: Reflections and Challenges in Understanding the Cell Biology of the Immune System >
I. Mellman
Emerging Challenges in Regulatory T Cell Function and Biology >
S. Sakaguchi and F. Powrie

Also in this issue:

News: A Slimy Start for Immunity?
M. Leslie

Report: Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
C. Auffray et al.

Report: Regulation of Homeostatic Chemokine Expression and Cell Trafficking During Immune Responses
S. N. Mueller et al.

Report: Negative Regulation of Toll-Like Receptor Signaling by NF-κB p50 Ubiquitination Blockade
R. J. Carmody, Q. Ruan, S. Palmer, B. Hilliard, Y. H. Chen

Report: Immune-like Phagocyte Activity in the Social Amoeba
G. Chen, O. Zhuchenko, A. Kuspa

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Uncovering Immunological Secrets >
J. F. Foley and E. M. Adler
Three articles highlight signals controlling T cell fate, T cell responsiveness, and the response to cytokines secreted by T cells.

PERSPECTIVE

NFAT in Lymphocytes--A Factor for All Events? >
E. Serfling, F. Berberich-Siebelt, A. Avots
The NFAT transcription factors may hold the key to T cell memory.

PERSPECTIVE

Diacylglycerol Kinases Put the Brakes on Immune Function >
B. W. Wattenberg and D. M. Raben
Diacylglycerol kinases are key negative regulators of immune responses in a broad array of cells.

REVIEW

A Role for the Cytoplasmic Adaptor Protein Act1 in Mediating IL-17 Signaling >
A. Lindén
Act1 may play a role in local inflammatory responses mediated by interleukin-17.

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