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The Gut: Inner Tube of Life

Jump to Features in
This Special Collection:

In Science Magazine
(with online extras)
In Science's STKE
In Science's SAGE KE
In this special collection, published with the 25 March 2005 issue, Science Magazine and its online Knowledge Environments focus on one of the body's most remarkable systems: The 10-meter-long tube of the gut, the mechanisms and activities of which are still largely mysterious. In Science, News, Viewpoint, and Review articles cover a range of topics in gut development, immunology, and disease, as well as the incredibly diverse gut flora and the gut-brain connection, a key in the obesity wars. Science's Signal Transduction Knowledge Environment presents four Perspective articles on various aspects of signaling both from the nervous system to the gut and within the gut epithelium. And the Science of Aging Knowledge Environment looks at how age-related neurodegenerative diseases affect the gut.

For registered individual users and AAAS members, we've prepared a suite of online extras, including a special interactive version of the poster featured in the print version, with additional images, multimedia, and links. (Not yet registered? Do so for free here.)

 

In Science

INTRODUCTION

The Gut: Inside Out
S. Simpson, C. Ash, E. Pennisi, J. Travis

NEWS

The Dynamic Gut
E. Pennisi

What's Eating You?
E. Pennisi

A Mouthful of Microbes
E. Pennisi

VIEWPOINT AND REVIEWS
No Organ Left Behind: Tales of Gut Development and Evolution
D. Y. R. Stainier

Self-Renewal and Cancer of the Gut: Two Sides of a Coin
F. Radtke and H. Clevers

The Gut and Energy Balance: Visceral Allies in the Obesity Wars
M. K. Badman and J. S. Flier

Host-Bacterial Mutualism in the Human Intestine
F. Bäckhed, R. E. Ley, J. L. Sonnenburg, D. A. Peterson, J. I. Gordon

Immunity, Inflammation, and Allergy in the Gut
T. T. MacDonald and G. Monteleone

In STKE

EDITORIAL GUIDE

Focus Issue -- Going for the Gut
E. M. Adler
Signaling processes from the nervous system to the gut as well as signaling in gut epithelia are featured.
PERSPECTIVES

Food Fight -- The NPY-Serotonin Link Between Aggression and Feeding Behavior
R. B. Emeson and M. V. Morabito
The synaptic circuits connecting aggression and eating are revealed in NPY receptor knockout mice.
Signaling the Junctions in Gut Epithelium
F. Hollande, A. Shulkes, G. S. Baldwin
The cell-to-cell junctions that seal the gut epithelium are also centers for cell signaling.

PERSPECTIVES

Orchestration of Aberrant Epithelial Signaling by Helicobacter pylori CagA
R. M. Peek Jr.
Phosphorylation of CagA and activation of SHP-2 have been implicated in the morphogenetic effects of H. pylori.
Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding -- A Perspective on the Munchies
K. A. Sharkey and Q. J. Pittman
Endocannabinoids coordinate food intake, metabolism, and energy expenditure.

In Science's SAGE KE


PERSPECTIVE

Age-Related Neurodegenerative Changes and How They Affect the Gut
P. R. Wade and P. J. Hornby
Although the gut "loses its mind" with age, it remains relatively functional.



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Science. ISSN 0036-8075 (print), 1095-9203 (online)