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Special Online Collection: Genomic Evolution: Building the Body from Genes

Jump to features in special collection:

Genomic EvolutionThis week, Science and its online companion sites the Signal Transduction Knowledge Ennvironment (STKE) and ScienceCareers.org explore what comparative genomics is teaching us about the forces that have promoted diversity or imposed constraints on our biological machinery. In Science, News and Review articles look at the genes that have helped shape our body plan, heart, eyes, and mind. Three Perspectives in STKE explore complex regulatory networks that allow genes to specify cell fate, tissue formation, and organ development. And a collection of articles on ScienceCareers.org highlights new career opportunities in human genetics and health.

In Science

INTRODUCTION

Genomic Tales >
B. R. Jasny, E. Pennisi, and J. Travis

NEWS

Mining the Molecules That Made Our Mind >
E. Pennisi
Graphic: The Evolution of Function & Form >

REVIEWS

Casting a Genetic Light on the Evolution of Eyes >
R. D. Fernald
Genomic Evolution of Hox Gene Clusters >
D. Lemons and W. McGinnis
Gene Regulatory Networks in the Evolution and Development of the Heart >
E. N. Olson

Also in this issue:

Editorial: Genetic Testing Oversight
K. Hudson

Research Article: The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
J. Lamb et al.

Perspective: Genomics and the Tree of Life
A. Rokas

Book Review: The Politics of Hope—Dreaming in a Genomic Age
S. S.-J. Lee

Book Review: DNA, Evolution, and the Moral Law
R. Pollack

Book Review: From Magnetic Mines to DNA and Consciousness
L. Orgel

Book Review: An Ointment for the Fly
J. C. Venter.

Also online this week:

On the Science Podcast

On this week's Science Podcast hear about mapping connections between drug candidates and disease, the evolution of eyes, new careers in genetics, and more.

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Focus Issue: From Genes to Tissues >
N. R. Gough
Complex regulatory networks allow genes to specify complex organisms.

PERSPECTIVE

Variations on a Theme—Hox and Wnt Combinatorial Regulation During Animal Development  >
S. Bondos
Hox proteins and Wnt signaling jointly induce subordinate genes required to establish cell or tissue identity.

PERSPECTIVE

Gene Control by Large Noncoding RNAs >
I. Shamovsky and E. Nudler
New studies implicate large noncoding RNAs in the control of gene transcription.

PERSPECTIVE

MAPping Out Arteries and Veins >
R. E. Lamont and S. Childs
Recent research implicates the MAPK pathway in promoting arterial fate.

In ScienceCareers.org

FEATURE INDEX

Special Feature: Human Genetics and Health Careers
E. Pain
The Human Genome Project and recent technological advances have created new opportunities for genetic scientists.

ARTICLES

Global: The Future of Genetics—Career Opportunities for Young Scientists
E. Pain
Science's Next Wave peeks into the new career avenues the sequencing of the human genome has opened, in academia and industry.
US: Your Genetic Future
J. Kling
Personalized medicine is the future, but for today's newly minted geneticists, it presents both uncertainty and opportunity.
Europe: Follow That Gene: The Story of Three Young Scientists
L. Blackburn
Next Wave talks to three research scientists in human genetics about their experiences and advice for getting started, and beyond.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)