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Drug Discovery: Big Risks, Big Rewards

Jump to Features in
This Special Collection:

In Science Magazine
In Science's STKE
In Science's Next Wave
In a collection of articles published beginning on 29 July 2005, Science Magazine and its online companion sites explore the "fiendishly complex, vastly expensive, and wildly unpredictable" proposition of discovering new drugs and bringing them to market. News articles in Science provide inside perspectives on the drug discovery process and on working in pharma both in the U.S. and in other countries. Articles in the Signal Transduction Knowledge Environment look at how genetics, RNAi, and systems biology are revealing new therapeutic targets. And Science's Next Wave profiles Johnson & Johnson's associate director of clinical drug evaluation, as part of a special feature on careers in industrial research.

 

In Science

In STKE

EDITORIAL GUIDE

Focus Issue -- Drug Discovery
N. R. Gough
Genetics, RNAi, and systems biology reveal new targets for therapeutic intervention.
PERSPECTIVE

How Will RNAi Facilitate Drug Development?
S. Bartz and A. L. Jackson
RNAi may be used in multiple steps in drug target identification.

PERSPECTIVE

Embracing Complexity, Inching Closer to Reality
E. E. Schadt, A. Sachs, S. Friend
Integrating high-throughput functional genomic and genotypic data with clinical trait data can elucidate signaling pathways associated with common human diseases.
REVIEW

TRP Channels in Disease
B. Nilius, T. Voets, J. Peters
Understanding the genetics of disease may allow development of new therapeutic agents.

In Science's Next Wave

FEATURE INDEX

Preparing for a Career in Industrial Research
R. Arnette
Next Wave explores how to have a successful career in industrial research.


FEATURE

Testing the Waters of Pharmaceutical Research
R. Arnette
Michael King is the associate director of clinical drug evaluation at Johnson & Johnson.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)