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Type 2 Diabetes

Jump to Features in
This Special Collection:

In Science Magazine
In Science's STKE
In Science's SAGE KE
Science Magazine and its online Knowledge Environments examine the vexing puzzle of type 2 diabetes -- a scourge expected nearly double in incidence, to some 300 million, over the next two decades. Viewpoint articles in Science overview the various molecular suspects that might underlie the disease, and explore the connections between diabetes and obesity. Science's Signal Transduction Knowledge Environment looks at insulin resistance mechanisms and pathways for stimulation of β-cell growth. And the Science of Aging Knowledge Environment offers a view on how studies of "the lowly spleen" are yielding insights on diabetes and aging-related diseases.

 

In Science

INTRODUCTION

A Surfeit of Suspects
P. A. Kiberstis

VIEWPOINTS
Genetic Factors in Type 2 Diabetes: The End of the Beginning?
S. O'Rahilly, I. Barroso, N. J. Wareham

How Obesity Causes Diabetes: Not a Tall Tale
M. A. Lazar

Diabetes, Obesity, and the Brain
M. W. Schwartz and D. Porte Jr.

Type 2 Diabetes—a Matter of β-Cell Life and Death?
C. J. Rhodes

Mitochondrial Dysfunction and Type 2 Diabetes
B. B. Lowell and G. I. Shulman

Also of related interest in this issue:

Editorial: Global Chronic Diseases
D. Yach, S. R. Leeder, J. Bell, B. Kistnasamy

Report: Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity
Ulrik Wisløff et al.
(with accompanying News story)

Report: Visfatin -- A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
A. Fukuhara et al.
(with accompanying Perspective)

In STKE

EDITORIAL GUIDE

Diabetes -- Fighting Fat on Multiple Fronts
E. M. Adler
Mechanisms of insulin resistance and pathways for stimulation of β-cell growth are highlighted.
PERSPECTIVE

Diabetes Outfoxed by GLP-1?
G. G. Holz and Oleg G. Chepurny
GLP-1 stimulates multiple pathways to stimulate pancreatic β-cell growth.

PERSPECTIVES

Lipid Microdomains and Insulin Resistance -- Is There a Connection?
E. Ikonen and S. Vainio
Alterations in plasma membrane lipid composition may alter insulin signaling.
Ser/Thr Phosphorylation of IRS Proteins -- A Molecular Basis for Insulin Resistance
Y. Zick
S6K1 participates in homeostatic negative feedback mechanisms that can also lead to insulin resistance.

In Science's SAGE KE


PERSPECTIVE

Diabetes and Stem Cell Researchers Turn to the Lowly Spleen
S. Kodama, M. Davis, D. L. Faustman
Splenic stem cells might offer hope for the treatment of aging-related disease.



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Science. ISSN 0036-8075 (print), 1095-9203 (online)