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Special Online Collection: Detection Technologies

Jump to features in special collection:

This week, Science and its companion online Signal Transduction Knowledge Environment (STKE) examine what's happening in the realm of direct detection techniques, increasingly important in solving problems that integrate basic analytical chemistry with biology and earth science. Reviews in Science reveal the state of the art in mass spectrometry and electrochemical detection, while three original research reports in the journal highlight further technological advances to improve detection. Related Perspectives on the STKE explore the implications, and challenges, of new detection technologies for studies of cell signaling.

In Science

INTRODUCTION

Chemical Detectives
N. Gough, P. Szuromi, J. Yeston

REVIEWS

Ambient Mass Spectrometry
R. G. Cooks, Z. Ouyang, Z. Takats, J. M. Wiseman
Probing Cellular Chemistry in Biological Systems with Microelectrodes
R. M. Wightman

Also in this issue:

Report: MOSFET-Embedded Microcantilevers for Measuring Deflection in Biomolecular Sensors
G. Shekhawat, S.-H. Tark, V. P. Dravid

Report: Broadband Cavity Ringdown Spectroscopy for Sensitive and Rapid Molecular Detection
M. J. Thorpe, K. D. Moll, R. J. Jones, B. Safdi, J. Ye

Report: Probing Gene Expression in Live Cells, One Protein Molecule at a Time
J. Yu, J. Xiao, X. Ren, K. Lao, X. S. Xie

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Focus Issue -- Measurement on a Small Scale
N. R. Gough
Advances in technology allow exploration of cell signaling at the level of individual molecules.

PERSPECTIVE

Multiple Routes for Glutamate Receptor Trafficking -- Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses
L. Cognet, L. Groc, B. Lounis, D. Choquet
Multiple techniques provide insight into receptor delivery mechanisms in neurons.

PERSPECTIVE

Detecting Cryptic Epitopes Created by Nanoparticles
I. Lynch, K. A. Dawson, S. Linse
Understanding how nanoparticles affect cell signaling is crucial to their application in medicine and research.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)