Science Magazine and its online Signal Transduction Knowledge Environment explore the new frontiers of scientific analysis being opened up by distributed and grid computing, in a collection of articles published with the magazine's 6 May 2005 issue. In a special section in
Science, News features chart the expanded realms of scientific number crunching made possible by screen-saver-computing efforts of the type pioneered by SETI@home, and at attempts to map the Internet itself using the same kind of techniques. Viewpoint articles in the same issue focus on the scientific promise of efforts such as the Semantic Web and other projects to tie the world's scientific computing infrastructure together through a common lingua franca. And articles in the
Signal Transduction Knowledge Environment look at the still-tricky business of extracting meaning automatically from enormous volumes of metabolic, signaling, and protein data.
In 
