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Cancer Treatment Gets Personal: Additional Resources
On this page we've gathered a number of additional resources related to the themes of the special online poster that accompanies the 26 May 2006 Science special issue on the new era in cancer research and treatment.
Cancer as a Genetic Disease
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RESEARCH PAPERS
- Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
- Scot A. Tomlins et al.
Science 28 October 2005; 310: 644-648
- Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
- Andrew P. Weng et al.
Science 8 October 2004; 306: 269-271
- Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways
- Raffaella Sordella et al.
Science 20 August 2004; 305: 1163-1167
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
- J. Guillermo Paez et al.
Science 4 June 2004; 304: 1497-1500
- Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers
- Zhenghe Wang et al.
Science 21 May 2004; 304: 1164-1166
- High Frequency of Mutations of the PIK3CA Gene in Human Cancers
- Yardena Samuels et al.
Science 23 April 2004; 304: 554
- Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
- Mary-Claire King et al.
Science 24 October 2003; 302: 643-646
- Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers
- Alberto Bardelli et al.
Science 9 May 2003; 300: 949
- PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors
- Michael C. Heinrich et al.
Science 31 January 2003; 299: 708-710
- BLM Heterozygosity and the Risk of Colorectal Cancer
- Stephen B. Gruber et al.
Science 20 September 2002; 297: 2013
- Biallelic Inactivation of BRCA2 in Fanconi Anemia
- Niall G. Howlett et al.
Science 26 July 2002; 297: 606-609
- Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
- Meenakshi Jain et al.
Science 5 July 2002; 297: 102-104
- Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification
- Mercedes E. Gorre et al.
Science 3 August 2001; 293: 876-880
REVIEWS AND PERSPECTIVES
- Addiction to Oncogenes--the Achilles Heal of Cancer
- I. Bernard Weinstein
Science 5 July 2002; 297: 63-64
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NEWS ARTICLES
- Fused Genes May Help Explain the Origins of Prostate Cancer
- Jean Marx
Science 28 October 2005; 310: 603
- Tackling the Cancer Genome
- Jocelyn Kaiser
Science 29 July 2005; 309: 693
- NCI Gears Up for Cancer Genome Project
- Jocelyn Kaiser
Science 25 February 2005; 307: 1182
- Choices--and Uncertainties--for Women With BRCA Mutations
- Jennifer Couzin
Science 24 October 2003; 302: 592
- Debate Surges Over the Origins of Genomic Defects in Cancer
- Jean Marx
Science 26 July 2002; 297: 544
WEB RESOURCES
The Cancer Genome Atlas
A US-based effort that aims to advance our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing.
The Cancer Genome Anatomy Project
A National Cancer Institute program that aims to determine the gene expression profiles of normal, precancer, and cancer cells, which will eventually lead to improved detection, diagnosis, and treatment for the patient.
The Cancer Genome Project
An initiative of the UK-based Wellcome Trust Sanger Institute to identify genes critical in the development of human cancers.
Catalog of Somatic Mutations in Cancer (COSMIC)
A database of somatic mutation data, organized by gene and by tissue, that includes information about the location and frequency of specific mutations and their relation to human cancers.
Oncomine
A tool for examining published cancer gene expression data, developed by physicians, scientists, and software engineers at the University of Michigan.
Myc Cancer Gene
A hub for the integration of information on target genes of the Myc ongogenic transcription factor, the role of Myc in human cancers, and proteins that interact with the Myc transcription factors.
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The Role of Microenvironment
Biomarkers
Targeted Therapies
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RESEARCH PAPERS
- Synergistic Antitumor Effects of Immune Cell-Viral Biotherapy
- Steve H. Thorne, Robert S. Negrin, Christopher H. Contag
Science 18 March 2005; 311: 1773-1776
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
- J. Guillermo Paez et al.
Science 4 June 2004; 304: 1497-1500
- In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
- Lyubomir T. Vassilev et al.
Science 6 February 2004; 303: 844-848
- Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
- David M. Berman et al.
Science 30 August 2002; 297: 1559-1561
- Tumor Regression by Targeted Gene Delivery to the Neovasculature
- John D. Hood et al.
Science 28 June 2002; 296: 2404-2407
- Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification
- Mercedes E. Gorre et al.
Science 3 August 2001; 293: 876-880
REVIEWS AND PERSPECTIVES
- Antiangiogenic Therapy: A Universal Chemosensitization Strategy For Cancer?
- Robert S. Kerbel
Science 26 May 2006; 312: 1171-1175
- Targeting Tyrosine Kinases in Cancer: The Second Wave
- Jose Baselga
Science 26 May 2006; 312: 1175-1178
- HIFing the Brakes: Therapeutic Opportunities for Treatment of Human Malignancies
- J. A. Garcia
Science's STKE 2006: pe25 [DOI: 10.1126/stke.3372006pe25]
- Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
- Rakesh K. Jain
Science 7 January 2005; 307: 58-62
- Targeting Apoptotic Pathways in Cancer Cells
- Catherine Denicourt and Steven F. Dowdy
Science 3 September 2004; 305: 1411-1413
- Empowering Targeted Therapy: Lessons from Rituximab
- Adam J. Olszewski and Michael L. Grossbard
Science's STKE 2004: pe30 [DOI: 10.1126/stke.2412004pe30]
- A Bull's Eye for Targeted Lung Cancer Therapy
- John D. Minna et al.
Science 4 June 2004; 304: 1458-1461
- Gleevec: Prototype or Outlier?
- William G. Kaelin Jr.
Science's STKE 2004: pe12 [DOI: 10.1126/stke.2252004pe12]
- Protein Kinase Inhibitors: Insights into Drug Design from Structure
- Martin E. M. Noble, Jane A. Endicott, Louise N. Johnson
Science 19 March 2004; 303: 1800-1805
- Matrix Metalloproteinase Inhibitors and Cancer -- Trials and Tribulations
- Lisa M. Coussens, Barbara Fingleton, Lynn M. Matrisian
Science 29 March 2002; 295: 2387-2392
- Mechanism-Based Target Identification and Drug Discovery in Cancer Research
- Jackson B. Gibbs
Science 17 March 2000; 287: 1969-1973
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NEWS ARTICLES
- Encouraging Results for Second-Generation Antiangiogenesis Drugs
- Jean Marx
Science 27 May 2005; 308: 1248-1249
- Why a New Cancer Drug Works Well, In Some Patients
- Jean Marx
Science 30 April 2004; 304: 658-659
- How Cells Endure Low Oxygen
- Jean Marx
Science 5 March 2004; 303: 1454-1456
- Gleevec, Chapter Two: New Leukemia Drug Aims to Overcome Resistance
- John Travis
Science 16 July 2004; 305: 319-321
- Drug Candidate Bolsters Cell's Tumor Defenses
- Jean Marx
Science 2 January 2004; 303: 23-25
- A Boost for Tumor Starvation
- Jean Marx
Science 25 July 2003; 301: 452-454
- Smart Weapons Prove Tough to Design
- Jennifer Couzin
Science 18 October 2002; 298: 522-525
- Nanoparticles Cut Tumors' Supply Lines
- Jennifer Couzin
Science 28 June 2002; 296: 2314-2315
WEB RESOURCES
Targeted Cancer Therapies: Questions and Answers
A comprehensive fact sheet from the National Cancer Institute.
Cancer Therapies
Information about antiangiogensis therapy and immunotherapy from the American Cancer Society.
Understanding Angiogenesis
An illustrated tutorial about angiogenesis and its importance in cancer research, from NCI.
Cancer Animations: Gleevec
A 3D animation showing how the drug disrupts the growth of leukemia cells, from the Howard Hughes Medical Institute's BioInteractive animation console.
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Cancer Stem Cells
MicroRNAs and Cancer
Nanotechnology and Cancer
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RESEARCH PAPERS
- Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics
- Chung-Cheng Lee et al.
Science 16 December 2005; 310: 1793-1796
- A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells
- Jaejoon Won et al.
Science 1 July 2005; 309: 121-125
- Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo
- Daniel R. Larson et al.
Science 30 May 2003; 300: 1434-1436
REVIEWS AND PERSPECTIVES
- Exploring and Engineering the Cell Surface Interface
- Molly M. Stevens and Julian H. George
Science 18 November 2005; 310: 1135-1138
- Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
- X. Michalet et al.
Science 28 January 2005; 307: 538-544
- Systems Biology and New Technologies Enable Predictive and Preventative Medicine
- Leroy Hood et al.
Science 22 October 2004; 306: 640-643
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NEWS ARTICLES
- Nanotechnology Takes Aim at Cancer
- Robert F. Service
Science 18 November 2005; 310: 1132-1134
- Tiny Transistors Scout for Cancer
- Robert F. Service
Science 11 April 2003; 300: 242-243
- Quantum Dots Get Wet
- Caroline Seydel
Science 4 April 2003; 300: 80-81
WEB RESOURCES
NCI Alliance for Nanotechnology in Cancer
Offers a comprehensive collection of resources including a technology backgrounder, animations, and a
video journey into technology,
Understanding Cancer Series: Nanodevices
An illustrated tutorial from NCI that explains nanotechnology and its potential to improve cancer detection, diagnosis, and treatment.
National Nanotechnology Initiative
A R&D program established to coordinate U.S. efforts in nanoscale science, engineering, and technology.
The Institute of Nanotechnology
A UK-based organization created to foster, develop, and promote all aspects of nanoscience and nanotechnology.
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