Special Online Collection: Cancer Treatment Gets Personal

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Special Online Collection: Cancer Treatment Gets Personal

Jump to features in special collection:

In Science
Online Poster
Podcast
In STKE
In SAGE KE

This week, Science and its online companion sites the Signal Transduction Knowledge Environment (STKE) and the Science of Aging Knowledge Environment (SAGE KE) look at the science of cancer -- at a time when advances in molecular biology in the lab have raised hopes of new, individualized approaches to cancer detection and treatment in the clinic. In Science, News and Perspective articles examine what it will take to make this new model of cancer treatment a reality, the role of biomarkers and molecular imaging in cancer diagnoses and treatment, and the status of anti-angiogenesis and other targeted therapies, as well as new activity in cancer bioenergetics and autophagy studies. Online, there's an interactive poster and a special podcast on the future of cancer treatment. Articles in STKE cover various examples of cell signaling's role in cancer, and SAGE KE features several Perspectives on cancer in a science-of-aging context.

In Science

INTRODUCTION

Celebrating a Glass Half-Full: P. Kiberstis and J. Travis

NEWS

Energy Deregulation: Licensing Tumors to Grow: K. Garber
Autophagy: Is It Cancer's Friend or Foe?: J. Marx

PERSPECTIVES

The New Era in Cancer Research: H. Varmus
Cancer Biomarkers -- An Invitation to the Table: W. S. Dalton and S. H. Friend
Molecular Imaging in Cancer: R. Weissleder
Antiangiogenic Therapy: A Universal Chemosensitization Strategy for Cancer?: R. S. Kerbel
Targeting Tyrosine Kinases in Cancer: The Second Wave: J. Baselga

Also online this week:

Poster: Cancer Treatment Gets Personal

online poster A special interactive version of the poster included with the Science 26 May special issue shows how advances in molecular biology have paved the way for a potential new model of cancer treatment -- one that puts the individual patient at the center.

Additional Resources

As a companion to the interactive poster, we've prepared a collection of additonal papers and Web links on the themes it explores.

On the Science Podcast

This week's entire show focuses on the new cancer science, including interviews with Sridhar Ramaswamy on the new patient-centered model of cancer treatment, Steven Friend on biomarkers, Ken Garber on cancer bioenergetics, and Mina Bissell on the role of the tissue microenvironment in tumor growth.

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Focus Issue: Turning the Corner in Cancer Therapy?: E. M. Adler, N. R. Gough, L. B. Ray
New insights into the molecular bases of cancer and the behavior of cancer cells may lead to pivotal changes in diagnosis and treatment.

PERSPECTIVE

HIFing the Brakes: Therapeutic Opportunities for Treatment of Human Malignancies: J. A. Garcia
Epidermal growth factor receptor signaling acts through the hypoxia-inducible factors to contribute to cancer progression.

PERSPECTIVE

p19^ras Brings a New Twist to the Regulation of p73 by Mdm2: K. L. Harms and X. Chen
An alternatively spliced form of the oncogene c-H-ras promotes activity of the p73 tumor suppressor.

In Science of Aging Knowledge Environment

PERSPECTIVES

Stem Cell Aging and Cancer: J. Fuller
Do stem cells age? Cancer studies may bring us closer to an answer.
The Age of Skin Cancers: A. Desai, R. Krathen, I. Orengo, and E. E. Medrano
Why are older men at greater risk for melanoma than older women?

NEWS FOCUS