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Special Web Supplement

Special Web Supplement:

Introduction
Neurodegenerative Diseases
Brain Disease: Neurodegenerative Diseases

The links below point to a variety of online resources on some of the neurodegenerative diseases discussed in Science's 31 October 2003 special issue on brain disease -- as well as to a small sampling of Science articles on these topics from recent issues. (For more on neurodegenerative diseases, also see our 6 November 1998 Neurodegeneration special issue.)

Alzheimer's Disease

Selected Web Resources
Alzheimer's Disease Education and Referral Center
Service of the National Institute of Aging that provides comprehensive information, including descriptions of current research and clinical trials, tips for caregivers, and links to other federal resources. Includes interesting general presentation Alzheimer's Disease: Unraveling the Mystery.
Alzheimer's Disease Fact Sheet
Information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Alzheimer's Association
A national voluntary health organization dedicated to advancing Alzheimer's research and helping those affected by the disease.
Alzheimer Week
Online Alzheimer's newsletter, updated daily, that includes information on research developments and answers to patient questions.
Alzheimer Research Forum
Rich "online scientific community" that provides links to research news, abstracts of current papers, informational resources for patients and caregivers, and a directory of researchers.
Alzheimer's Disease at OMIM
Exhaustive literature review on clinical features, genetics, inheritance, and other aspects of Alzheimer's, from the NIH Online Mendelian Inheritance in Man destination.
MedlinePlus: Alzhemier's Disease
Excellent collection of resources from the U.S. National Library of Medicine.
Selected Science Articles
News Focus: Insulin Insults May Spur Alzheimer's Disease
Gary Taubes
Science 301, 40-41 (2003)
[Summary] [Full text]
Viewpoint: Alzheimer's Disease Is a Synaptic Failure
Dennis J. Selkoe
Science 298, 789-791 (2002)
[Abstract] [Full text]
News Focus: New Alzheimer's Treatments That May Ease the Mind
Laura Helmuth
Science 297, 1260-1262 (2002)
[Summary] [Full text]
Review: The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy and Dennis J. Selkoe
Science 297, 353-356 (2002)
[Abstract] [Full text]
Review: Toxic Proteins in Neurodegenerative Disease
J. Paul Taylor, John Hardy, and Kenneth H. Fischbeck
Science 296, 1991-1995 (2002)
[Abstract] [Full text]
News Focus: New Leads on the 'How' of Alzheimer's
Jean Marx
Science 293, 2192-2194 (2001)
[Summary] [Full text]
Review: A Portrait of Alzheimer Secretases--New Features and Familiar Faces
William P. Esler and Michael S. Wolfe
Science 293, 1449-1454 (2001)
[Abstract] [Full text]
Report: Susceptibility Locus for Alzheimer's Disease on Chromosome 10
Amanda Myers et al.
Science 290, 2304-2305 (2000)
[Abstract] [Full text]
Report: Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Nilufer Ertekin-Taner et al.
Science 290, 2303-2304 (2000)
[Abstract] [Full text]
Report: Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
Lars Bertram et al.
Science 290, 2302-2303 (2000)
[Abstract] [Full text]
[Top of page]

Parkinson's Disease

Selected Web Resources
Parkinson's Disease Foundation
A national nonprofit organization devoted to education, advocacy, and the funding of research.
Parkinson's Disease Backgrounder
Fact sheet provided by the NINDS.
Parkinson's Disease Interactive Tutorial
Patient-oriented information resource from the National Library of Medicine's MedlinePlus (requires Flash plug-in).
ClinicalTrials.gov: Parkinson's Disease
Regularly updated information about federally and privately supported clinical research on Parkinson's disease, made available by the NIH.
Parkinson's Disease at MayoClinic.com
Informative discussion hosted by the Clinic Web site's Brain and Nervous System Center.
The National Parkinson Foundation, Inc.
A worldwide organization dedicated to research and providing educational and medical information for Parkinson patients, their families, neurologists, and general medical practitioners.
Parkinson's Disease at OMIM
Thorough discussion of the genetics of Parkinson's, from the NIH Online Mendelian Inheritance in Man destination.
MedlinePlus: Parkinson's Disease
Rich assembly of links from the U.S. National Library of Medicine.
Selected Science Articles
Report: Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati et al.
Science 299, 256-259 (2003); published online November 21, 2002, 10.1126/science.1077209
[Abstract] [Full text]
Report: Subthalamic GAD Gene Therapy in a Parkinson's Disease Rat Model
Jia Luo et al.
Science 298, 425-429 (2002)
[Abstract] [Full text]
Review: Toxic Proteins in Neurodegenerative Disease
J. Paul Taylor, John Hardy, and Kenneth H. Fischbeck
Science 296, 1991-1995 (2002)
[Abstract] [Full text]
Report: Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease
Jeffrey H. Kordower et al.
Science 290, 767-773 (2000)
[Abstract] [Full text]
Perspective: Combating Parkinson's Disease--Step Three
Lars Olson
Science 290, 721-724 (2000)
[Summary] [Full text]
[Top of page]

Huntington's Disease

Selected Web Resources
Huntington's Disease Society of America
Advocacy group's Web site includes a wealth of information on the disease.
Huntington's Disease: Hope Through Research
Information booklet on Huntington's disease compiled by the NINDS.
Huntington Disease: What Is It?
Engaging general-audience presentation on how Huntington's disease is inherited, from the Your Genes, Your Health section of Cold Spring Harbor Labs' DNA Learning Center.
ClinicalTrials.gov: Huntington's Disease
Regularly updated information about federally and privately supported clinical research on Huntington's disease; made available by the NIH.
International Huntington Association
A federation of national voluntary health agencies that promotes education, individual and family support, and biomedical research.
Understanding Huntington's Disease
A general overview of the disease provided by MayoClinic.com.
Huntington's Disease at OMIM
Comprehensive review of Huntington's biochemistry, inheritance, population genetics, and other characteristics, from the NIH Online Mendelian Inheritance in Man destination.
MedlinePlus: Huntington's Disease
Links from the U.S. National Library of Medicine.
Selected Science Articles
Review: Toxic Proteins in Neurodegenerative Disease
J. Paul Taylor, John Hardy, and Kenneth H. Fischbeck
Science 296, 1991-1995 (2002)
[Abstract] [Full text]
Report: Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
Chiara Zuccato et al.
Science 293, 493-498 (2001)
[Abstract] [Full text]
Perspective: Huntingtin--Profit and Loss
Yvon Trottier and Jean Louis Mandel
Science 293, 445 (2001)
[Summary] [Full text]
[Top of page]

CJD and Prion Diseases

Selected Web Resources
Creutzfeldt-Jakob Disease Foundation, Inc.
Seeks to promote the research, education and awareness of CJD.
Creutzfeldt-Jakob Disease Fact Sheet
An information page compiled by the NINDS.
BSE and CJD Information and Resources
Links to articles, epidemiology reports, and other resources on Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob disease; made available by the National Center for Infectious Diseases of the Centers for Disease Control and Prevention.
Priondata.org
An information resource on prions and prion diseases that includes links to current news and research.
The Prion Diseases
Overview article by Stanley B. Prusiner in Scientific American.
Creutzfeldt-Jakob Disease at OMIM
Review of CJD genetics, from the NIH Online Mendelian Inheritance in Man destination.
Selected Science Articles
Perspective: A View from the Top--Prion Diseases from 10,000 Feet
Suzette A. Priola, Bruce Chesebro, Byron Caughey
Science 300, 917 (2003)
[Summary] [Full text]
News Focus: Prion Disease Treatment's Early Promise Unravels
Peter Follette
Science 299, 191-192 (2003)
[Summary] [Full text]
Review: Toxic Proteins in Neurodegenerative Disease
J. Paul Taylor, John Hardy, and Kenneth H. Fischbeck
Science 296, 1991-1995 (2002)
[Abstract] [Full text]
Research Article: Evidence for the Prion Hypothesis: Induction of the Yeast [PSI+] Factor by in Vitro- Converted Sup35 Protein
Helmut E. Sparrer, Alex Santoso, Francis C. Szoka Jr., and Jonathan S. Weissman
Science 289, 595-599 (2000)
[Abstract] [Full text]
Perspective: Sowing the Protein Seeds of Prion Propagation
Mick F. Tuite
Science 289, 556-557 (2003)
[Summary] [Full text]
[Top of page]
[Note on access: Abstracts/summaries of the Science articles on this page, as well as full text of Research Articles and Reports published more than 12 months ago, are available free with registration. Access to full text of news articles, Viewpoints, Perspectives, and Reviews, and to research papers published less than 12 months ago, is available free to AAAS members and institutional subscribers or via individual article purchase.]

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Science. ISSN 0036-8075 (print), 1095-9203 (online)