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Special Online Collection: Tools for Biochemistry

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This week, Science and the Signal Transduction Knowledge Environment (STKE) review some of the technological advances that are helping scientists understand, quantitatively, how dynamic macromolecules function inside of cells. In Science, Review and Perspective articles explore recent progress in mass spectrometry, NMR spectrometry, fluorescent probes, and single-molecule imaging -- and research papers elsewhere in the issue show some of these tools in action. STKE, meanwhile, offers a Review on fluorescence resonance energy transfer and a Protocol on monitoring AMPA receptor trafficking.

In Science

INTRODUCTION

Proteins at Work >
V. J. Vinson

REVIEWS

Mass Spectrometry and Protein Analysis >
B. Domon and R. Aebersold
The Fluorescent Toolbox for Assessing Protein Location and Function >
B. N. G. Giepmans, S. R. Adams, M. H. Ellisman, R. Y. Tsien
New Tools Provide New Insights in NMR Studies of Protein Dynamics >
A. Mittermaier and L. E. Kay

PERSPECTIVE

Living Cells as Test Tubes >
X. S. Xie, J. Yu, W. Y. Yang

Also in this issue:

Perspective: Enzyme Motions Inside and Out
S. J. Benkovic and S. Hammes-Schiffer

Research Article: Atomic Description of an Enzyme Reaction Dominated by Proton Tunneling
L. Masgrau et al.

Report: Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
A. Koglin et al.

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Focus Issue -- Peering Into the Proteome >
E. M. Adler
New approaches leverage the wealth of proteomic data to reveal insights into protein function and localization.

REVIEW

Fanciful FRET >
S. S. Vogel, C. Thaler, S. V. Koushik
Accurate measurement of energy transfer efficiency enhances the usefulness of FRET analysis.

PROTOCOL

Rapid Photoinactivation of Native AMPA Receptors on Live Cells Using ANQX >
P. M. England
ANQX provides a means of directly monitoring native AMPA-type glutamate receptor trafficking in real time.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)