Science's SAGE KE http://sageke.sciencemag.org/ Science of Aging Knowledge Environment American Association for the Advancement of Science Heather McDonald (mailto:hmcdonal@aaas.org) Copyright 2006 American Association for the Advancement of Science 2006-06-28T19:27:31-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [VIEWPOINT] I Come Not to Bury SAGE KE, but to Appraise It http://sageke.sciencemag.org/cgi/content/full/2006/10/vp1?rss=1 One of the site's creators tells a personal story of its rise and demise. Evelyn Strauss [NEWS FOCUS] Death-Bed Prophecy http://sageke.sciencemag.org/cgi/content/full/2006/10/nf17?rss=1 On the eve of its termination, SAGE KE takes a look at the future of research on aging. Mitch Leslie [REVIEW] Targeting the Role of the Endosome in the Pathophysiology of Alzheimer's Disease: A Strategy for Treatment http://sageke.sciencemag.org/cgi/content/full/2006/10/re2?rss=1 Alzheimer's disease-associated endosomal abnormalities might provide a route for drug-based interventions. Barbara A. Tate and Paul M. Mathews [CASE STUDY] Dementia with Cerebrovascular Disease http://sageke.sciencemag.org/cgi/content/full/2006/10/dn1?rss=1 A case study. Clinton B. Wright, Jean Paul G. Vonsattel, Karen Bell, and Lawrence S. Honig [PERSPECTIVE] WRN's Tenth Anniversary http://sageke.sciencemag.org/cgi/content/full/2006/10/pe18?rss=1 What have we learned about RecQ helicase function in a segmental progeroid syndrome and normal aging? Fuki M. Hisama, Vilhelm A. Bohr, and Junko Oshima [PERSPECTIVE] The Unusual Genetics of Human Longevity http://sageke.sciencemag.org/cgi/content/full/2006/10/pe20?rss=1 Centenarians provide a unique opportunity for understanding "longevity genes." Giovanna De Benedictis and Claudio Franceschi [PERSPECTIVE] Aging On the Job http://sageke.sciencemag.org/cgi/content/full/2006/10/pe16?rss=1 As the population ages, will the workforce decline along with it? James Levine, Justin Heet, and Barbara Burlingame [PERSPECTIVE] The Role of Mitochondria in Conserved Mechanisms of Aging http://sageke.sciencemag.org/cgi/content/full/2006/10/pe15?rss=1 Report from the second "MiMage" symposium describes research on a variety of systems. Christian Scheckhuber and Heinz D. Osiewacz [PERSPECTIVE] Developing a Research Agenda in Biogerontology: Physiological Systems http://sageke.sciencemag.org/cgi/content/full/2006/10/pe17?rss=1 Research supported by the National Institute on Aging aims to understanding the biology of aging tissues. Jill L. Carrington and Francis L. Bellino [PERSPECTIVE] From Bedside to Bench: Does Mental and Physical Activity Promote Cognitive Vitality in Late Life? http://sageke.sciencemag.org/cgi/content/full/2006/10/pe21?rss=1 Conference looks at the role of exercise for promoting mental health and delaying dementia. Stephanie Studenski, Michelle C. Carlson, Howard Fillit, William T. Greenough, Arthur Kramer, and George W. Rebok [PERSPECTIVE] A Work in Progress: The Metabolic Syndrome http://sageke.sciencemag.org/cgi/content/full/2006/10/pe19?rss=1 Should we diagnose and treat the metabolic syndrome? Jose A. Luchsinger [CLASSIC PAPER] Mutation Selection and the Natural History of Cancer http://sageke.sciencemag.org/cgi/content/abstract/2006/10/cp1?rss=1 Nature 255, 197 (1975). John Cairns Papers of Note http://sageke.sciencemag.org/cgi/content/full/2006/10/nw10?rss=1 See what the SAGEKE editors selected as the most exciting research in the field of aging.