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In this December 2008 special feature, Science and Science Signaling highlight exciting advances in our understanding of how organs develop. In the 5 December issue of Science, five Review articles examine the complexities of heart, liver, and pancreas development; the origin of stem cells in organogenesis; the collective cell movements involved in tissue and organ growth; and the patterning mechanisms of branched organs such as the vertebrate mammary gland and lung. In the 9 December issue of Science Signaling, Review and Perspective articles highlight aspects of plant organogenesis and a Research Article offers molecular insights into mammalian kidney formation.
In Science
In Science Signaling
EDITORIAL GUIDE
- Focus Issue: Organ Development from Beginning to End
- Annalisa M. VanHook
Cell signaling events play a key role in the induction, regulation, and maintenance of organ development.
RESEARCH ARTICLE
- Analysis of Metagene Portraits Reveals Distinct Transitions During Kidney Organogenesis
- Igor Tsigelny, Valentina Kouznetsova, Derina E. Sweeney, Wei Wu, Kevin T. Bush, Sanjay K. Nigam
Grouping microarray expression data into metagenes, followed by organization of
these gene clusters into self-organizing maps, reveals distinct stages of kidney organogenesis.
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PERSPECTIVE
- Intercellular Peptide Signals Regulate Plant Meristematic Cell Fate Decisions
- Julie E. Gray, Stuart Casson, Lee Hunt
By controlling stem cell fate, secreted peptides control the formation of many plant cell types.
REVIEW
- De Novo Organ Formation from Differentiated Cells: Root Nodule Organogenesis
- Martin Crespi and Florian Frugier
Root nodule organogenesis in legumes is initiated by bacterial signals and directed by plant signaling pathways.
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