Choose your 2018 Breakthrough of the Year!

It’s that time of the year again: Science’s reporters and editors are homing in on the Breakthrough of the Year, our choice of the most significant scientific discovery, development, or trend in 2018. That selection, along with nine runners-up, will be announced when the last issue of the year goes online on 20 December.

You can get in on the action! Pick your favorite breakthrough from the candidates below by Wednesday, 5 December. Then check back on Thursday, 6 December, when we will start a second round of voting with your four top picks. We will announce the winner—the People’s Choice—along with Science’s choice on 20 December.

Cast your vote today!

Editor’s note: We originally included the claim of gene-edited babies as a candidate; we have since removed it to avoid giving the mistaken impression that Science endorses this ethically fraught work.