*Update, 11 December, 12 a.m.: Voting has closed. Check back on 21 December to see your winner, along with Science's choice for the 2017 Breakthrough of the Year.
On 21 December, the editors and news writers of Science will announce their selection of the most significant scientific breakthrough of 2017. We invited you to choose from among the candidates and, with some 11,000 votes cast, the four below rose to the top. Now is your chance to decide which of them will be the People’s Choice for Breakthrough of the Year. Vote by 10 December, and check back after 2 p.m. EST on 21 December to see how your choice stacks up against ours.