Choose your breakthrough of the year!

*Update, 4 December: The finalists are in! Click here to choose your favorite of the remaining four candidates.

It’s that time of the year again … the Science news writers and editors are homing in on the “Breakthrough of the Year,” their choice of the most significant scientific discovery, development, or trend in 2017. That selection, along with nine runners-up, will be announced when the last issue of the year goes online on 21 December.

Now, you can get in on the action! Pick your favorite breakthrough from the list of candidates below by 3 December. Then check back the next day, when we will start a second round of voting with your four top picks. We will announce your winner—the People’s Choice—along with Science’s choice on 21 December.

Cast your vote today!