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Newly discovered state of memory could help explain learning and brain disorders

Memory researchers have shone light into a cognitive limbo. A new memory—the name of someone you've just met, for example—is held for seconds in so-called working memory, as your brain's neurons continue to fire. If the person is important to you, the name will over a few days enter your long-term memory, preserved by permanently altered neural connections. But where does it go during the in-between hours, when it has left your standard working memory and is not yet embedded in long-term memory?

In Science, a research team shows that memories can be resurrected from this limbo. Their observations point to a new form of working memory, which they dub prioritized long-term memory, that exists without elevated neural activity. Consistent with other recent work, the study suggests that information can somehow be held among the synapses that connect neurons, even after conventional working memory has faded.

"This is a really fundamental find—it's like the dark matter of memory," says Geoffrey Woodman, a cognitive neuroscientist at Vanderbilt University in Nashville who was not involved with the work. "It's hard to really see it or measure it in any clear way, but it has to be out there. Otherwise, things would fly apart."

Cognitive neuroscientist Nathan Rose and colleagues at the University of Wisconsin (UW) in Madison initially had subjects watch a series of slides showing faces, words, or dots moving in one direction. They tracked the resulting neural activity using functional magnetic resonance imaging (fMRI) and, with the help of a machine learning algorithm, showed they could classify the brain activity associated with each item. Then the subjects viewed the items in combination—a word and face, for example—but were cued to focus on just one item. At first, the brain signatures of both items showed up, as measured in this round with electroencephalography (EEG). But neural activity for the uncued item quickly dropped to baseline, as if it had been forgotten, whereas the EEG signature of the cued item remained, a sign that it was still in working memory. Yet subjects could still quickly recall the uncued item when prompted to remember it a few seconds later.

Rose, who recently left UW for the University of Notre Dame in South Bend, Indiana, and his colleagues then turned to transcranial magnetic stimulation (TMS), a noninvasive method that uses rapidly changing magnetic fields to deliver a pulse of electrical current to the brain. They had subjects perform the same cued memory task, then applied a broad TMS pulse just after the signature of the uncued memory item had faded. The appropriate neural activity for that "forgotten" item spiked, showing the memory was reactivated into immediate consciousness from its latent state. What's more, when the TMS directly targeted the brain areas that were initially active for the uncued item, the reactivation response was even stronger.

The study doesn't address how synapses or other neuronal features can hold this second level of working memory, or how much information it can store. "It's a primitive early step in understanding how we bring things into mind," says UW cognitive neuroscientist Bradley Postle, a study co-author.

Woodman agrees. "Good studies tend to bring to light more questions than they answer," he says. "This work absolutely does that." Ultimately, he says, this new memory state could have a range of practical implications, from helping college students learn more efficiently to assisting people with memory-related neurological conditions such as amnesia, epilepsy, and schizophrenia. 

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