The finalists are in—make your pick for Breakthrough of the Year

What would you nominate as the most momentous scientific discovery, development, or trend of 2016? Less than three weeks from now our news writers and editors will announce their choice for Science’s “Breakthrough of the Year.” At the same time, we’ll unveil your pick--the People’s Choice.

We’ve just finished one round of voting with more than 11,000 votes tallied. Now it’s time to make your voice heard again. Choose your winner from among the five finalists, listed below. Cast your vote today, and check back on December 22 to see how your choice stacks up against ours.