In many parts of the world, hunting is taking a steep toll on wild animals. This week, Science takes an in-depth look at how overhunting has affected one of the most diverse forests in the world. Lambir Hills National Park in western Borneo, depicted in this slideshow, is protected from logging and agriculture, but the diversity of large animals has dropped precipitously over the last 3 decades. Researchers are learning about the knock-on effects that could put the forest itself at risk. A related special issue lays out how humans, in addition to hunting, are inflicting many kinds of harm on animal communities.