Long-Lasting Drug Could Thwart HIV

Breaking the cycle. One GSK744 injection may disrupt infection for months by inhibiting HIV integration.

Breaking the cycle. One GSK744 injection may disrupt infection for months by inhibiting HIV integration.

G.Grullón/Science

Antiretroviral drugs can protect people from becoming infected by HIV. But so-called pre-exposure prophylaxis, or PrEP, only works if people take pills daily—which studies show they have trouble doing. Now, monkey experiments with an integrase inhibitor that's injected show how a single shot protects them from the AIDS virus for 11 weeks on average. The drug lasts even longer in humans, which may provide a promising new approach to PrEP.

For the full story, see this week's issue of Science.

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