Dan Koshland, 1920–2007

Protein pioneer.
Daniel Koshland revolutionized protein chemistry before becoming editor-in-chief of Science.

University of California, Berkeley

Daniel E. Koshland Jr., Science's editor-in-chief from 1985 to 1995, died on 23 July, 2 days after suffering a massive stroke.

Koshland, who joined the faculty of the University of California, Berkeley, in 1965, put his stamp on a broad swath of protein chemistry. His fundamental insight that proteins change shape as they interact with other molecules--the "induced fit" theory--changed the way scientists perceived a range of processes, from the catalytic power of enzymes to the action of hormones. He published more than 400 papers, an output that continued unabated in recent years.

He also left his mark on Science. He overhauled the peer-review process, establishing a Board of Reviewing Editors; oversaw the internationalization of the journal with the launch of an office in Europe and news bureaus around the world; and increased the number of top-quality papers in the physical sciences. "He had an unmatched talent for recognizing quality," says Executive Editor Monica Bradford.

Don Kennedy, Science's current editor-in-chief, says: "As a grateful successor, I find traces of Dan's thoughtful influence everywhere at Science. Dan has been my colleague in planning the Koshland Museum at the National Academy--a jewel that results from a generous gift to honor his late wife, Bunny. It is difficult to lose a hero and a friend in the same person."

A retrospective of Koshland's life will be published in a forthcoming issue of Science, and a page of personal staff remembrances is posted at www.sciencemag.org/sciext/koshland.

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