The long aftermath of Fukushima
Five years after the meltdowns at the Fukushima atomic plant, evacuees face the prospect of living near a nuclear disaster zone for decades to come.
4 March 2016
Vol. 351, No. 6277, Pages 1036-a-1106
Five years after the meltdowns at the Fukushima atomic plant, evacuees face the prospect of living near a nuclear disaster zone for decades to come.
Promote reproducibility by moving beyond “available upon request”
Connectivity patterns in human brain circuits can predict distinct motivations for similar observed behaviors. [Also see Perspective by Gluth and Fontanesi]
Tumor-initiating cells differentiate to a more benign state when treated with drugs that activate protein kinase A.
Nongenetic heterogeneity can lead to genetic variation.
Exquisitely preserved fossil lizards from 99-million-year-old Burmese amber provide new insights into paleotropical diversity.
A universal cooperative assembly method is developed for growing mesostructured TiO2 shells on diverse functional particles.
Red Queen dynamics are observed in selected genotypes, whereas the rest of the genotypes remain subordinate in synchronized dynamics.
Mechanical energy in vivo could be harvested by BD-TENG in a designed time frame.
9 March 2016
Vol. 8, No. 329, Pages 329ec40-329ra32
S. aureus α toxin promotes opportunistic co-infection, which can be neutralized with a pathogen-specific antibody.
New inhibitors of wall teichoic acid biosynthesis restore susceptibility of drug-resistant staphylococci to β-lactam antibiotics.
A two–monoclonal antibody cocktail protects nonhuman primates against Ebola virus 3 days after lethal exposure.
A cyclic prosaposin-derived peptide targets ovarian cancer cells through the fatty acid translocase CD36.
If the ultimate goal of controlling an infectious disease is to interrupt transmission, the current global TB strategy is not succeeding.
The termination of dedicated funding for integrated MD-PhD trainees has left biomedical researchers to question the future of physician-scientists in Canada.
8 March 2016
Vol. 9, No. 418, Pages eg3-ra26
T cells and mast cells may use differential glycosylation of Orai1 to regulate store-operated calcium signaling.
Monocytes adjust deadly reactive oxygen species production by altering the subunit composition of the ORAI calcium channel.
Blocking an adhesion molecule on the surface of T cells may enhance antitumor activity.
A Ca2+-accumulating region in Orai1 facilitates ion permeation and contributes to selectivity.
Cholesterol inhibits CRAC channels, which replenish intracellular stores.
Understanding how ORAI activity is regulated will lead to a better understanding of immune cell function and diseases involving the immune system.
