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In the 28 March 2008 issue, Science and its online sister journal Science Signaling examine the range of mechanisms used by cells to control the expression of their constituent genes. In Science, a series of Perspectives discuss the roles of protein transcription factors and noncoding RNAs in regulating gene expression, and the importance of other factors such as polymerase pausing and the spatial organization of chromosomes. A related News story explores the the roles of microRNAs in disease. In Science Signaling, three Perspectives discuss how an oncogenic protein directs the silencing of tumor suppressor genes, how intrachromosomal looping can stimulate gene expression, and how the abundance of a transcriptional coactivator affects nuclear receptor–mediated transcription. An online video presentation accompanies the special issue and highlights the central role of RNA in gene regulatory circuits.
In Science
INTRODUCTION
- Freedom of Expression
- Guy Riddihough, Beverly A. Purnell, John Travis
- Video: Gene Regulation
- A video introduction focusing on RNA's role in gene regulation and the evolution of life.
NEWS
- MicroRNAs Make Big Impression in Disease After Disease
- Jennifer Couzin
Hunting for new ways to diagnose and treat common diseases, biologists and companies are racing to decipher the promise of these RNAs.
PERSPECTIVES
- Gene Regulation by Transcription Factors and MicroRNAs
- Oliver Hobert
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- The Eukaryotic Genome as an RNA Machine
- Paulo P. Amaral, Marcel E. Dinger, Tim R. Mercer, John S. Mattick
- Multilevel Regulation of Gene Expression by MicroRNAs
- Eugene V. Makeyev, Tom Maniatis
- Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II
- Leighton J. Core, John T. Lis
- Gene Regulation in the Third Dimension
- Job Dekker
- Complex Riboswitches
- Ronald R. Breaker
- Evolution of Eukaryotic Transcription Circuits
- Brian B. Tuch, Hao Li, Alexander D. Johnson
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In Science Signaling
