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Science Functional Genomics
Research

Whole Genomes and Comparative Genomics




Whole Genomes

Policy Forum: GENETICS:
Chicken Genome--Science Nuggets to Come Soon

Dave Burt and Olivier Pourquie
Science, 13 June 2003, p. 1669
[Summary] [Full Text]

In-Depth View of Structure, Activity, and Evolution of Rice Chromosome 10
The Rice Chromosome 10 Sequencing Consortium
Science, 6 June 2003, p. 1566-1569
[Abstract] [Full Text]

Perspective: PLANT SCIENCE:
Surprises Inside a Green Grass Genome

Michael Bevan
Science, 6 June 2003, p. 1514-1515
[Summary] [Full Text]

Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
Paul A. Rota et al.
Science, 30 May 2003, p. 1394-1399; published online May 1, 2003; 10.1126/science.1085952
[Abstract] [Full Text]

The Genome Sequence of the SARS-Associated Coronavirus
Marco A. Marra et al.
Science, 30 May 2003, p. 1399-1404; published online May 1, 2003; 10.1126/science.1085953
[Abstract] [Full Text]

Perspective: VIROLOGY:
The SARS Coronavirus: A Postgenomic Era

Kathryn V. Holmes and Luis Enjuanes
Science, 30 May 2003, p. 1377-1378
[Summary] [Full Text]

Human Chromosome 7: DNA Sequence and Biology
Stephen W. Scherer et al.
Science, 2 May 2003, p. 767-772; published online April 10, 2003; 10.1126/science.1083423
[Abstract] [Full Text]

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells
Lawrence Lum et al.
Science, 28 March 2003, p. 2039-2045
[Abstract] [Full Text]

News: RNA INTERFERENCE:
New Screen Nets 'Hedgehog' Genes

Jennifer Couzin
Science, 28 March 2003, p. 1961
[Summary] [Full Text]

Ringlike Structure of the Deinococcus radiodurans Genome: A Key to Radioresistance?
Smadar Levin-Zaidman et al.
Science, 10 January 2003, p. 254-256
[Abstract] [Full Text]

The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins
Paramvir Dehal et al.
Science, 13 December 2002, p. 2157-2167
[Abstract] [Full Text]

News: COMPARATIVE GENOMICS:
Tunicate Genome Shows a Little Backbone

Elizabeth Pennisi
Science, 13 December 2002, p. 2111-2112
[Summary] [Full Text]

A Polytene Chromosome Analysis of the Anopheles gambiae Species Complex
Mario Coluzzi, Adriana Sabatini, Alessandra della Torre, Maria Angela Di Deco, and Vincenzo Petrarca
Science, 15 November 2002, p. 1415-1418; published online October 3, 2002; 10.1126/science.1077769
[Abstract] [Full Text]

Viewpoint: The Plasmodium falciparum Genome-- a Blueprint for Erythrocyte Invasion
Alan F. Cowman and Brendan S. Crabb
Science, 4 October 2002, p. 126-128
[Abstract] [Full Text]

The Genome Sequence of the Malaria Mosquito Anopheles gambiae
Robert A. Holt et al.
Science, 4 October 2002, p. 129-149
[Abstract] [Full Text]

Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
Samuel Aparicio et al.
Science, 23 August 2002, p. 1301-1310; published online July 25, 2002, 10.1126/science.1072104
[Abstract] [Full Text]

Perspective: GENOMICS:
Vertebrate Genomes Compared

S. Blair Hedges and Sudhir Kumar
Science, 23 August 2002, p. 1283-1285
[Summary] [Full Text]

Chemical Synthesis of Poliovirus cDNA: Generation of Infectious Virus in the Absence of Natural Template
Jeronimo Cello, Aniko V. Paul, and Eckard Wimmer
Science, 9 August 2002, p. 1016-1018; published online July 11, 2002, 10.1126/science.1072266
[Abstract] [Full Text]

Large-Scale Transcriptional Activity in Chromosomes 21 and 22
Philipp Kapranov et al.
Science, 3 May 2002, p. 916-919
[Abstract] [Full Text]

A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. indica)
Jun Yu et al.
Science, 5 April 2002, p. 79-92
[Abstract] [Full Text]

A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. japonica)
Stephen A. Goff et al.
Science, 5 April 2002, p. 92-100
[Abstract] [Full Text]

News, Perspectives, and other articles related to the Rice Genome

Functional Annotation of a Full-Length Arabidopsis cDNA Collection
Motoaki Seki et al.
Science, 5 April 2002, p. 141-145; published online March 21, 2002, 10.1126/science.1071006
[Abstract] [Full Text]

Capturing Chromosome Conformation
Job Dekker et al.
Science, 15 February 2002, p. 1306-1311
[Abstract] [Full Text]

Combined Functional Genomic Maps of the C. elegans DNA Damage Response
Simon J. Boulton et al.
Science, 4 January 2002, p. 127-131
[Abstract] [Full Text]

Miniature Genome in the Marine Chordate Oikopleura dioica
Hee-Chan Seo et al.
Science, 21 December 2001, p. 2506
[Full Text]

A DNA Microarray-Based Genetic Screen for Nonhomologous End-Joining Mutants in Saccharomyces cerevisiae
Siew Loon Ooi, Daniel D. Shoemaker, and Jef D. Boeke
Science, 21 December 2001, p. 2552-2556; published online November 8, 2001, 10.1126/science.1065672
[Abstract] [Full Text]

The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58
Derek W. Wood et al.
Science, 14 December 2001, pp. 2317-2323
[Abstract] [Full Text]

Genome Sequence of the Plant Pathogen and Biotechnology Agent Agrobacterium tumefaciens C58
Brad Goodner et al.
Science, 14 December 2001, pp. 2323-2328
[Abstract] [Full Text]

News: MICROBIAL GENOMES:
New Genome a Boost to Plant Studies

Elizabeth Pennisi
Science, 14 December 2001, p. 2266
[Summary] [Full Text]

Replication Dynamics of the Yeast Genome
M. K. Raghuraman et al.
Science, 5 October 2001, pp. 115-121
[Abstract] [Full Text]

Identification of Critical Staphylococcal Genes Using Conditional Phenotypes Generated by Antisense RNA
Yinduo Ji et al.
Science, 21 September 2001, p. 2266-2269
[Abstract] [Full Text]

An Evaluation of the Draft Human Genome Sequence
Nicholas Katsanis, Kim C. Worley, and James R. Lupski
Nature Genetics, 7 September 2001, p. 88-91
[Abstract] [Full Text]

The Composite Genome of the Legume Symbiont Sinorhizobium meliloti
F. Galibert et al.
Science, 27 July 2001, p. 668-673
[Abstract] [Full Text]

Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Hervé Tettelin et al.
Science, 20 July 2001, p. 498-506
[Abstract] [Full Text]

News: MICROBIOLOGY:
S. pneumoniae Genome Falls to Sequencers

Dan Ferber
Science, 20 July 2001, p. 410-411
[Summary] [Full Text]

Perspective: GENOMICS:
On Choosing Mammalian Genomes for Sequencing

Stephen J. O'Brien, Eduardo Eizirik, and William J. Murphy
Science, 22 June 2001, p. 2264-2265
[Summary] [Full Text]

Future Directions: What If There Are Only 30,000 Human Genes?
Jean-Michel Claverie
Science, 16 February 2001, p. 1255-1257
[Summary] [Full Text]

A High-Resolution Radiation Hybrid Map of the Human Genome Draft Sequence
M. Olivier et al.
Science, 16 February 2001, p. 1298-1302
[Abstract] [Full Text]

The Sequence of the Human Genome
J. Craig Venter et al.
Science, 16 February 2001, p. 1304-1351
[Abstract] [Full Text] [Web Fig. 1]

Perspective: GENOMICS:
Genomics Happens

Victor J. DiRita
Science, 1 September 2000, p. 1488-1489
[Summary] [Full Text]

Viewpoint: The Drosophila Genome Sequence: Implications for Biology and Medicine
Thomas B. Kornberg and and Mark A. Krasnow
Science, 24 March 2000, p. 2218-2220
[Abstract] [Full Text]

Cover Figure

Review: The Genome Sequence of Drosophila melanogaster
Mark D. Adams et al.
Science, 24 March 2000, p. 2185-2195
[Abstract] [Full Text]

A BAC-Based Physical Map of the Major Autosomes of Drosophila melanogaster
Roger A. Hoskins et al.
Science, 24 March 2000, p. 2271-2274
[Abstract] [Full Text]

Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58
Hervé Tettelin et al.
Science, 10 March 2000, p. 1809-1815
[Abstract] [Full Text]

Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing
Mariagrazia Pizza et al.
Science, 10 March 2000, p. 1816-1820
[Abstract] [Full Text]

Perspective: MICROBIOLOGY:
A Furtive Pathogen Revealed

Xavier Nassif
Science, 10 March 2000, p. 1767-1768
[Summary] [Full Text]

Global Transposon Mutagenesis and a Minimal Mycoplasma Genome
Clyde A. Hutchison III et al.
Science, 10 December 1999, p. 2165-2169
[Abstract] [Full Text]

Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1
Owen White et al.
Science, 19 November 1999, p. 1571-1577
[Abstract] [Full Text]

A Genetic Map and Recombination Parameters of the Human Malaria Parasite Plasmodium falciparum
Xin-zhuan Su et al.
Science, 12 November 1999, p. 1351-1353
[Abstract] [Full Text]

News: INFECTIOUS DISEASES:
Malarial Genome Comes Into View

Elizabeth Pennisi
Science, 12 November 1999, p. 1263-1265
[Summary] [Full Text]

Whole-Genome Shotgun Optical Mapping of Deinococcus radiodurans
Jieyi Lin et al.
Science, 3 September 1999, p. 1558-1562
[Abstract] [Full Text]

Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology
The C. elegans Sequencing Consortium
Science, 11 December 1998, pp. 2012-2018
[Abstract] [Full Text]

Arabidopsis thaliana: A Model Plant for Genome Analysis
David W. Meinke, J. Michael Cherry, Caroline Dean, Steven D. Rounsley, and Maarten Koornneef
Science, 23 October 1998, pp. 662-663
[Abstract] [Full Text]

Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis
Richard S. Stephens, et al.
Science, 23 October 1998, pp. 754-759
[Abstract] [Full Text]

Perspectives: GENOME SEQUENCING:
Chlamydia: Old Ideas Crushed, New Mysteries Bared

Thomas Hatch
Science, 23 October 1998, pp. 638-639
[Summary] [Full Text]

 




Comparative Genomics

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
Siu Sylvia Lee, Scott Kennedy, Andrew C. Tolonen, and Gary Ruvkun
Science, 25 April 2003, p. 644-647; published online April 10, 2003; 10.1126/science.1083614
[Abstract] [Full Text]

Phylogenetic Shadowing of Primate Sequences to Find Functional Regions of the Human Genome
Dario Boffelli et al.
Science, 28 February 2003, p. 1391-1394
[Abstract] [Full Text]

Perspective: HUMAN GENETICS:
Primate Shadow Play

Richard A. Gibbs and David L. Nelson
Science, 28 February 2003, p. 1331-1333
[Summary] [Full Text]

Viewpoint: The Anopheles Genome and Comparative Insect Genomics
Thomas C. Kaufman, David W. Severson, and Gene E. Robinson
Science, 4 October 2002, p. 97-98
[Abstract] [Full Text]

Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
Evgeny M. Zdobnov et al.
Science, 4 October 2002, p. 149-159
[Abstract] [Full Text]

A Low Genomic Number of Recessive Lethals in Natural Populations of Bluefin Killifish and Zebrafish
A.R. McCune, R.C. Fuller, A.A. Aquilina, R.M. Dawley, J.M. Fadool, D. Houle, J. Travis, A.S. Kondrashov
Science, 28 June 2002, pp. 2398-2401
[Abstract] [Full Text]

Comparative Genome Sequencing for Discovery of Novel Polymorphisms in Bacillus anthracis
Timothy D. Read et al.
Science, 14 June 2002, pp. 2028-2033; published online May 9, 2002, 10.1126/science.1071837
[Abstract] [Full Text]

Perspective: Microbial Forensics--When Pathogens Are "Cross-Examined"
Craig A. Cummings and David A. Relman
Science, 14 June 2002, pp. 1976-1979; published online May 9, 2002, 10.1126/science.1073125
[Summary] [Full Text]

A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome
Richard J. Mural et al.
Science, 31 May 2002, pp. 1661-1671
[Abstract] [Full Text]

Perspective: GENOMICS:
Mmu 16--Comparative Genomic Highlights

Neal G. Copeland, Nancy A. Jenkins, and Stephen J. O'Brien
Science, 31 May 2002, p. 1617-1618
[Summary] [Full Text]

News: GENOMICS:
Charting a Genome's Hills and Valleys

Elizabeth Pennisi
Science, 31 May 2002, p. 1601-1603
[Summary] [Full Text]

An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis
Hannu Myllykallio et al.
Science, published online May 23, 2002, 10.1126/science.1072113
[Abstract]

Perspective: DNA Building Block Reinvented
Alexey G. Murzin
Science, published online May 23, 2002, 10.1126/science.1073910
[Abstract]

Review: Plants Compared to Animals: The Broadest Comparative Study of Development
Elliot M. Meyerowitz
Science, 22 February 2002, pp. 1482-1485
[Abstract] [Full Text]

Review: Organogenesis--Heart and Blood Formation from the Zebrafish Point of View
Christine Thisse and Leonard I. Zon
Science, 18 January 2002, pp. 457-462
[Abstract] [Full Text]

Construction and Analysis of a Human-Chimpanzee Comparative Clone Map
Asao Fujiyama et al.
Science, 4 January 2002, pp. 131-134
[Abstract] [Full Text]

Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae: High-Resolution Mapping of Replication Origins
John J. Wyrick et al.
Science, 14 December 2001, pp. 2357-2360
[Abstract] [Full Text]

Perspectives: DNA REPLICATION:
Genomic Views of Genome Duplication

Bruce Stillman
Science, 14 December 2001, p. 2301-2304
[Summary] [Full Text]

Comparative Genomics of Listeria Species
P. Glaser et al.
Science, 26 October 2001, pp. 849-852
[Abstract] [Full Text]

Protein Structure Prediction and Structural Genomics
David Baker and Andrej Sali
Science, 5 October 2001, pp. 93-96
[Abstract] [Full Text]

An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Len A. Pennacchio et. al
Science, 5 October 2001, pp. 169-173
[Abstract] [Full Text]

Perspectives: GENOME RESEARCH:
Possible New Heart Disease Risk Factor

Caroline Seydel
Science, 5 October 2001, p. 33
[Summary] [Full Text]

Global Efforts in Structural Genomics
Raymond C. Stevens, Shigeyuki Yokoyama, and Ian A. Wilson
Science, 5 October 2001, pp. 89-92
[Abstract] [Full Text]

Impact of Landscape Management on the Genetic Structure of Red Squirrel Populations
Marie L. Hale, Peter W. W. Lurz, Mark D. F. Shirley, Steven Rushton, Robin M. Fuller, Kirsten Wolff
Science, 21 September 2001, p. 2246-2248
[Abstract] [Full Text]

Perspectives: COMPARATIVE BIOLOGY:
Building a Case for Biological Corridors

Jocelyn Kaiser
Science, 21 September 2001, p. 2199
[Summary] [Full Text]

Mechanisms of Evolution in Rickettsia conorii and R. prowazekii
Hiroyuki Ogata et al.
Science, 14 September 2001, p. 2093-2098
[Abstract] [Full Text]

Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses
Masato Hatta, Peng Gao, Peter Halfmann, and Yoshihiro Kawaoka
Science, 7 September 2001, p. 1840-1842
[Abstract] [Full Text]

Recombination in the Hemagglutinin Gene of the 1918 "Spanish Flu"
Mark J. Gibbs, John S. Armstrong, and Adrian J. Gibbs
Science, 7 September 2001, p. 1842-1845
[Abstract] [Full Text]

Perspectives: VIROLOGY:
A Molecular Whodunit

Robert G. Webster
Science, 7 September 2001, p. 1773-1775
[Summary] [Full Text]

Perspectives: VIROLOGY:
The Origin and Control of Pandemic Influenza

Graeme Laver and Elspeth Garman
Science, 7 September 2001, p. 1776-1777
[Summary] [Full Text]

Human Chromosome 19 and Related Regions in Mouse: Conservative and Lineage-Specific Evolution
P. Dehal et al.
Science, 6 July 2001, p. 104-111
[Abstract] [Full Text]

Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters
S. A. Farber et al.
Science, 18 May 2001, p. 1385-1389
[Abstract] [Full Text]

Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
P. Baumann and T. R. Cech
Science, 11 May 2001, p. 1171-1175
[Abstract] [Full Text]

Perspective: CELL BIOLOGY:
Telomere Capping--One Strand Fits All

T. de Lange
Science, 11 May 2001, p. 1075-1076
[Summary] [Full Text]

Regulation of Longevity and Stress Resistance by Sch9 in Yeast
P. Fabrizio et al.
Science, 13 April 2001, p. 288-290
[Abstract] [Full Text]

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
D. J. Clancy et al.
Science, 6 April 2001, p. 104-107
[Abstract] [Full Text]

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
M. Tatar et al.
Science, 6 April 2001, p. 107-110
[Abstract] [Full Text]

News: LONGEVITY:
Growing Old Together

Evelyn Strauss
Science, 6 April 2001, p. 44-45
[Summary] [Full Text]

Apoptotic Molecular Machinery: Vastly Increased Complexity in Vertebrates Revealed by Genome Comparisons
L. Aravind, V. M. Dixit, E. V. Koonin
Science, 16 February 2001, p. 1279-1284
[Abstract] [Full Text]

Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster
S. M. Kanzok et al.
Science, 26 January 2001, p. 643-646
[Abstract] [Full Text]

Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
J. L. Riechmann et al.
Science, 15 December 2000, p. 2105-2110
[Abstract] [Full Text]

Letter: Examining Priorities for a Primate Genome Project
John L. VandeBerg, Sarah Williams-Blangero, Bennett Dyke, Jeffrey Rogers; Edwin H. McConkey, and Ajit Varki
Science, 24 November 2000, p. 1503
[Full Text]

Letter: A Primate Genome Project Deserves High Priority
Edwin H. McConkey and Ajit Varki
Science, 25 August 2000, p. 1295
[Full Text]

Bacterial Mode of Replication with Eukaryotic-Like Machinery in a Hyperthermophilic Archaeon
Hannu Myllykallio et al.
Science, 23 June 2000, p. 2212-2215
[Abstract] [Full Text]

Review: Comparative Genomics of the Eukaryotes
Gerald M. Rubin et al.
Science, 24 March 2000, p. 2204-2215
[Abstract] [Full Text]

Evidence for DNA Loss as a Determinant of Genome Size
Dmitri A. Petrov, Todd A. Sangster, J. Spencer Johnston, Daniel L. Hartl, and Kerry L. Shaw
Science, 11 February 2000, p. 1060-1062
[Abstract] [Full Text]

Perspective: EVOLUTION:
Is Bigger Better in Cricket?

Pierre Capy
Science, 11 February 2000, p. 985-986
[Summary] [Full Text]

Extensive Nuclear DNA Sequence Diversity Among Chimpanzees
Henrik Kaessmann, Victor Wiebe, and Svante Pääbo
Science, 5 November 1999, p. 1159-1162
[Abstract] [Full Text]

Cover Figure

Review: The Promise of Comparative Genomics in Mammals
Stephen J. O'Brien et al.
Science, 15 October 1999, p. 458-481
[Abstract] [Full Text]

Map: Comparative Genomics: Mammalian Radiations
Genome Maps 10
Science, 15 October 1999, p. 463-478
[Full Text]

Plant Paralog to Viral Movement Protein That Potentiates Transport of mRNA into the Phloem
Beatriz Xoconostle-Cázares et al.
Science, 1 January 1999, p. 94-98
[Abstract] [Full Text]

News: BIOLOGY:
RNA Molecules May Carry Long-Distance Signals in Plants

Evelyn Strauss
Science, 1 January 1999, p. 12-13
[Summary] [Full Text]

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence
Stephen A. Chervitz, et al.
Science, 11 December 1998, pp. 2022-2028
[Abstract] [Full Text]

Neurobiology of the Caenorhabditis elegans Genome
Cornelia I. Bargmann
Science, 11 December 1998, pp. 2028-2033
[Abstract] [Full Text]

The Taxonomy of Developmental Control in Caenorhabditis elegans
Gary Ruvkun and Oliver Hobert
Science, 11 December 1998, pp. 2033-2041
[Abstract] [Full Text]

Caenorhabditis elegans Is a Nematode
Mark Blaxter
Science, 11 December 1998, pp. 2041-2046
[Abstract] [Full Text]

Zebrafish hox Clusters and Vertebrate Genome Evolution
Angel Amores et al.
Science, 27 November 1998, pp. 1711-1714
[Abstract] [Full Text]

Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum
Malcolm J. Gardner et al.
Science, 6 November 1998, pp. 1126-1132
[Abstract] [Full Text]

Viewpoint: Plant Comparative Genetics after 10 Years
M. D. Gale, and K. M. Devos
Science, 23 October 1998, pp. 656-659
[Abstract] [Full Text]

 




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