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Science Functional Genomics
Research

Transgenic Animals/Animal Models

Impact of Genetic Manipulation on the Fitness of Anopheles stephensi Mosquitoes
Flaminia Catteruccia, H. Charles J. Godfray, and Andrea Crisanti
Science, 21 February 2003, p. 1225-1227
[Abstract] [Full Text]

Production of alpha 1,3-Galactosyltransferase-Deficient Pigs
Carol J. Phelps et al.
Science, 17 January 2003, p. 411-414; published online December 19, 2002; 10.1126/science.1078942
[Abstract] [Full Text]

Viewpoint: The Ecology of Genetically Modified Mosquitoes
Thomas W. Scott, Willem Takken, Bart G. J. Knols, and Christophe Boëte
Science, 4 October 2002, p. 117-119
[Abstract] [Full Text]

Viewpoint: Malaria Control with Genetically Manipulated Insect Vectors
Luke Alphey et al.
Science, 4 October 2002, p. 119-121
[Abstract] [Full Text]

Brevia: Generation of Live Young from Xenografted Mouse Ovaries
Melanie Snow, Shae-Lee Cox, Graham Jenkin, Alan Trounson, and Jillian Shaw
Science, 27 September 2002, p. 2227
[Full Text]

Impaired B and T Cell Antigen Receptor Signaling in p110d PI 3-Kinase Mutant Mice
Klaus Okkenhaug et al.
Science, 9 August 2002, p. 1031-1034; published online July 18, 2002, 10.1126/science.1073560
[Abstract] [Full Text]

bAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
Eric S. Bachman et al.
Science, 2 August 2002, p. 843-845
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
A Sympathetic Defense Against Obesity

Abdul G. Dulloo
Science, 2 August 2002, p. 782
[Summary] [Full Text]

Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2
Lisa Stowers, Timothy E. Holy, Markus Meister, Catherine Dulac, and Georgy Koentges
Science, 22 February 2002, p. 1493-1500; published online January 31 2002, 10.1126/science.1069259
[Abstract] [Full Text]

News: PHEROMONE RECEPTION:
When in Doubt, Mice Mate Rather Than Hate

Mary Beckman
Science, 1 February 2002, p. 782
[Summary] [Full Text]

Production of a-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning
Liangxue Lai et al.
Science, 8 February 2002, p. 1089-1092; published online January 3 2002, 10.1126/science.1068228
[Abstract] [Full Text]

Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Carlos Lois et al.
Science, 1 February 2002, p. 868-872; published online January 10, 2002, 10.1126/science.1067081
[Abstract] [Full Text]

Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor b
Yan Zhu et al.
Science, 18 January 2002, pp. 505-508
[Abstract] [Full Text]

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
Hiroaki Masuzaki et al.
Science, 7 December 2001, pp. 2166-2170
[Abstract] [Full Text]

News: OBESITY RESEARCH:
Pot-Bellied Mice Point to Obesity Enzyme

Trisha Gura
Science, 7 December 2001, p. 2071
[Summary] [Full Text]

Cloned Cattle Can Be Healthy and Normal
Robert P. Lanza et al.
Science, 30 November 2001, pp. 1893-1894
[Abstract] [Full Text]

Chromosome-Specific Single-Locus FISH Probes Allow Anchorage of an 1800-Marker Integrated Radiation-Hybrid/Linkage Map of the Domestic Dog Genome to All Chromosomes
Matthew Breen et al.
Science, October 2001, pp. 1784-1795
[Abstract] [Full Text]

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Marek Drab et al.
Science, 28 September 2001, pp. 2449-2452
[Abstract] [Full Text]

Perspective: CELL BIOLOGY:
Life Without Caveolae

Robert G. Parton
Science, 28 September 2001, pp. 2404-2405
[Summary] [Full Text]

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
J. Lewis et al.
Science, 24 August 2001, p. 1487-1491
[Abstract] [Full Text]

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Ab42 Fibrils
J. Götz et al.
Science, 24 August 2001, p. 1491-1495
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Tauists and baptists United - Well Almost!

Virginia M.-Y. Lee
Science, 24 August 2001, p. 1446
[Summary] [Full Text]

Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles
C. Wittmann et al.
Science, 27 July 2001, p. 711-714
[Abstract] [Full Text]

A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier
Marc Lecuit et al.
Science, 1 June 2001, p. 1722-1725
[Abstract] [Full Text]

Perspective: MICROBIOLOGY:
Cracking Listeria's Password

B. Brett Finlay
Science, 1 June 2001, p. 1665-1667
[Summary] [Full Text]

Transgenic Monkeys Produced by Retroviral Gene Transfer into Mature Oocytes
A. W. S. Chan et al.
Science, 12 January 2001, p. 309-312
[Abstract] [Full Text]

News: TRANSGENIC ANIMALS:
Infant Monkey Carries Jellyfish Gene

Gretchen Vogel
Science, 12 January 2001, p. 226
[Summary] [Full Text]

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
H. Nishimura et al.
Science, 12 January 2001, p. 319-322
[Abstract] [Full Text]

Myotonic Dystrophy in Transgenic Mice Expressing an Expanded CUG Repeat
Ami Mankodi et al.
Science, 8 September 2000, p. 1769-1772
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Deconstructing Myotonic Dystrophy

Stephen J. Tapscott
Science, 8 September 2000, p. 1701-1702
[Summary] [Full Text]

mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination
Taeko Ichise et al.
Science, 9 June 2000, p. 1832-1835
[Abstract] [Full Text]

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats
Shin Yamazaki et al.
Science, 28 April 2000, p. 682-685
[Abstract] [Full Text]

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Phillip L. Lowrey et al.
Science, 21 April 2000, p. 483-491
[Abstract] [Full Text]

Figure 1

Perspective: CIRCADIAN RHYTHMS:
Marking Time for a Kingdom

Michael W. Young
Science, 21 April 2000, p. 451-453
[Summary] [Full Text]

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model
Mingwei Li et al.
Science, 14 April 2000, p. 335-339
[Abstract] [Full Text]

Perspective: NEUROBIOLOGY:
Stay the Executioner's Hand

Mark E. Gurney, Alfredo G. Tomasselli, and Robert L. Heinrikson
Science, 14 April 2000, p. 283-284
[Summary] [Full Text]

Genetic Suppression of Polyglutamine Toxicity in Drosophila
Parsa Kazemi-Esfarjani and Seymour Benzer
Science, 10 March 2000, p. 1837-1840
[Abstract] [Full Text]

Transgenic Mouse Model of Stunned Myocardium
Anne M. Murphy et al.
Science, 21 January 2000, p. 488-491
[Abstract] [Full Text]

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1
G. Thurston et al.
Science, 24 December 1999, p. 2511-2514
[Abstract] [Full Text]

Impaired Immunoproteasome Assembly and Immune Responses in PA28-/- Mice
Tobias Preckel et al.
Science, 10 December 1999, p. 2162-2165
[Abstract] [Full Text]

Mouse Models of Tumor Development in Neurofibromatosis Type 1 
Karen Cichowski et al.
Science, 10 December 1999, p. 2172-2176
[Abstract] [Full Text]

Mouse Tumor Model for Neurofibromatosis Type 1 
Kristine S. Vogel et al.
Science, 10 December 1999, p. 2176-2179
[Abstract] [Full Text]

Requirement for B Cell Linker Protein (BLNK) in B Cell Development
Rajita Pappu et al.
Science, 3 December 1999, p. 1949-1954
[Abstract] [Full Text]

Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein
Neng-Yao Shih et al.
Science, 8 October 1999, p. 312-315
[Abstract] [Full Text]

News: CELL BIOLOGY:
First Components Found for Key Kidney Filter

Ingrid Wickelgren
Science, 8 October 1999, p. 225-226
[Summary] [Full Text]

Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene
Mounib Elchebly et al.
Science, 5 March 1999, p. 1544-1548
[Abstract] [Full Text]

News: CELL BIOLOGY:
New Clues Found to Diabetes and Obesity

Dan Ferber
Science, 5 March 1999, p. 1423-1425
[Summary] [Full Text]

Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models
Donald L. Price, Sangram S. Sisodia, and David R. Borchelt
Science, 6 November 1998, pp. 1079-1083
[Abstract] [Full Text]

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah
Yi-Jyun Lin, Laurent Seroude, and Seymour Benzer
Science, 30 October 1998, pp. 943-946
[Abstract] [Full Text]

News: AGING RESEARCH:
Single Gene Controls Fruit Fly Life-Span

Elizabeth Pennisi
Science, 30 October 1998, p. 856
[Summary] [Full Text]

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1
Lucie I. Bruijn et al.
Science, 18 September 1998, pp. 1851-1854
[Abstract] [Full Text]

Disruption of a Neuropeptide Gene, flp-1, Causes Multiple Behavioral Defects in Caenorhabditis elegans
Laura S. Nelson, Marc L. Rosoff, and Chris Li
Science, 11 September 1998, p. 1686-1690
[Abstract] [Full Text]

 




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