Brevia: Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
Danielle A. Garsin et al.
Science, 20 June 2003, p. 1921
[Full Text]

Crystal Structure of the Potassium Channel KirBac1.1 in the Closed State
Anling Kuo et al.
Science, 20 June 2003, p. 1922-1926; published online May 8, 2003; 10.1126/science.1085028
[Abstract] [Full Text]

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver
Keyong Du, Stephan Herzig, Rohit N. Kulkarni, and Marc Montminy
Science, 6 June 2003, p. 1574-1577
[Abstract] [Full Text]

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Stephen E. Girardin et al.
Science, 6 June 2003, p. 1584-1587
[Abstract] [Full Text]

Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gß
David T. Lodowski, Julie A. Pitcher, W. Darrell Capel, Robert J. Lefkowitz, and John J. G. Tesmer
Science, 23 May 2003, p. 1256-1262
[Abstract] [Full Text]

A Modular PIP₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity
Elizabeth D. Prescott and David Julius
Science, 23 May 2003, p. 1284-1288
[Abstract] [Full Text]

Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1
Jennifer LeCouter et al.
Science, 7 February 2003, p. 890-893
[Abstract] [Full Text]

GUN4, a Regulator of Chlorophyll Synthesis and Intracellular Signaling
Robert M. Larkin, Jose M. Alonso, Joseph R. Ecker, and Joanne Chory
Science, 7 February 2003, p. 902-906
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Love, Honor, and Protect (Your Liver)
Alan J. Davidson and Leonard I. Zon
Science, 7 February 2003, p. 835-837
[Summary] [Full Text]

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Matthias Blüher, Barbara B. Kahn, and C. Ronald Kahn
Science, 24 January 2003, p. 572-574
[Abstract] [Full Text]

Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense
Ilhem Messaoudi, Jose A. Guevara Patiño, Ruben Dyall, Joël LeMaoult, and Janko Nikolich-ugich
Science, 29 November 2002, p. 1797-1800
[Abstract] [Full Text]

Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
Y. Whitney Yin and Thomas A. Steitz
Science, 15 November 2002, p. 1387-1395; published online September 19, 2002; 10.1126/science.1077464
[Abstract] [Full Text]

Neuropeptides and Peptide Hormones in Anopheles gambiae
Michael A. Riehle, Stephen F. Garczynski, Joe W. Crim, Catherine A. Hill, and Mark R. Brown
Science, 4 October 2002, p. 172-175
[Abstract] [Full Text]

G Protein-Coupled Receptors in Anopheles gambiae
Catherine A. Hill et al.
Science, 4 October 2002, p. 176-178
[Abstract] [Full Text]

Nucleotide Control of Interdomain Interactions in the Conformational Reaction Cycle of SecA
John F. Hunt et al.
Science, 20 September 2002, p. 2018-2026
[Abstract] [Full Text]

Nitrogenase MoFe-Protein at 1.16 Å Resolution: A Central Ligand in the FeMo-Cofactor
Oliver Einsle et al.
Science, 6 September 2002, p. 1696-1700
[Abstract] [Full Text]

Perspective: STRUCTURE:
Nitrogenase Reveals Its Inner Secrets
Barry E. Smith
Science, 6 September 2002, p. 1654-1655
[Summary] [Full Text]

Structures of Glycoprotein Iba and Its Complex with von Willebrand Factor A1 Domain
Eric G. Huizinga et al.
Science, 16 August 2002, p. 1176-1179
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Contact—How Platelets Touch von Willebrand Factor
J. Evan Sadler
Science, 2 August 2002, p. 1128-1129
[Summary] [Full Text]

Correlating Structural Dynamics and Function in Single Ribozyme Molecules
Xiaowei Zhuang et al.
Science, 24 May 2002, p. 1473-1476
[Abstract] [Full Text]

Structural Basis of Transcription Initiation: RNA Polymerase Holoenzyme at 4 Å Resolution
Katsuhiko S. Murakami, Shoko Masuda, and Seth A. Darst
Science, 17 May 2002, p. 1280-1284
[Abstract] [Full Text]

Structural Basis of Transcription Initiation: An RNA Polymerase Holoenzyme-DNA Complex
Katsuhiko S. Murakami, Shoko Masuda, Elizabeth A. Campbell, Oriana Muzzin, and Seth A. Darst
Science, 17 May 2002, p. 1285-1290
[Abstract] [Full Text]

Structural Insights into Group II Intron Catalysis and Branch-Site Selection
Lan Zhang and Jennifer A. Doudna
Science, 15 March 2002, p. 2084-2088; published online February 21, 2002, 10.1126/science.1069268
[Abstract] [Full Text]

Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
Dylan J. Taatjes et al.
Science, 8 February 2002, p. 1058-1062
[Abstract] [Full Text]

Perspective: TRANSCRIPTION:
Mediator Meets Morpheus
Michael Meisterernst
Science, 8 February 2002, p. 984-985
[Summary] [Full Text]

Visualization of DNA Replication on Individual Epstein-Barr Virus Episomes
Paolo Norio and Carl L. Schildkraut
Science, 14 December 2001, p. 2361-2364
[Abstract] [Full Text]

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Amy Hin Yan Tong et al.
Science, 14 December 2001, p. 2364-2368
[Abstract] [Full Text]

Structural Mechanisms of QacR Induction and Multidrug Recognition
Maria A. Schumacher et al.
Science, 7 December 2001, p. 2158-2163
[Abstract] [Full Text]

Chromosome Dynamics in the Yeast Interphase Nucleus
Patrick Heun, Thierry Laroche, Kenji Shimada, Patrick Furrer, and Susan M. Gasser
Science, 7 December 2001, p. 2181-2186
[Abstract] [Full Text]

Delineation of mRNA Export Pathways by the Use of Cell-Permeable Peptides
Imed-Eddine Gallouzi and Joan A. Steitz
Science, 30 November 2001, p. 1895-1901
[Abstract] [Full Text]

Crystal structure of Arp2/3 complex
Robert C. Robinson et al.
Science, 23 November 2001, p. 1679-1684
[Abstract] [Full Text]

Collaboration Between CC- and A-Adding Enzymes to Build and Repair the 3'-Terminal CCA of tRNA in Aquifex aeolicus
Kozo Tomita and Alan M. Weiner
Science, 9 November 2001, p. 1334-1336
[Abstract] [Full Text]

A DNA Microarray-Based Genetic Screen for Nonhomologous End-Joining Mutants in Saccharomyces cerevisiae
Siew Loon Ooi, Daniel D. Shoemaker, and Jef D. Boeke
Science, 8 November 2001
[Abstract]

Structural Basis for Recognition of the Intron Branch Site RNA by Splicing Factor 1
Zhihong Liu, et al.
Science, 2 November 2001, p. 1098-1102
[Abstract] [Full Text]

Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms
Tae Kondo, Tatsushi Wakayama, Takahiro Naiki, Kunihiro Matsumoto, and Katsunori Sugimoto
Science, 26 October 2001, p. 867-870
[Abstract] [Full Text]

Crystal Structure of an Early Protein-RNA Assembly Complex of the Signal Recognition Particle
Klemens Wild, Irmgard Sinning, and Stephen Cusack
Science, 19 October 2001, p. 598-601
[Abstract] [Full Text]

Genetic Basis for Activity Differences Between Vancomycin and Glycolipid Derivatives of Vancomycin
Ulrike S. Eggert, Natividad Ruiz, Brian V. Falcone, Arthur A. Branstrom, Robert C. Goldman, Thomas J. Silhavy, and Daniel Kahne
Science, 12 October 2001, p. 361-364
[Abstract] [Full Text]

Conversion of a Peroxiredoxin into a Disulfide Reductase by a Triplet Repeat Expansion
Daniel Ritz, Jackie Lim, C. Michael Reynolds, Leslie B. Poole, and Jon Beckwith
Science, 5 October 2001, p. 158-160
[Abstract] [Full Text]

Strand-Specific Postreplicative Processing of Mammalian Telomeres
S. M. Bailey, M. N. Cornforth, A. Kurimasa, D. J. Chen, and E. H. Goodwin
Science, 28 September 2001, p. 2462-2465
[Abstract] [Full Text]

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity
R.E. Watkins et al.
Science, 22 June 2001, p. 2329-2333
[Abstract] [Full Text]

Sorting of Mannose 6-Phosphate Receptors Mediated by the GGAs
Rosa Puertollano, Rubén C. Aguilar, Inna Gorshkova, Robert J. Crouch, and Juan S. Bonifacino
Science, 1 June 2001, p. 1712-1716
[Abstract] [Full Text]

Binding of GGA2 to the Lysosomal Enzyme Sorting Motif of the Mannose 6-Phosphate Receptor
Yunxiang Zhu, Balraj Doray, Anssi Poussu, Veli-Pekka Lehto, and Stuart Kornfeld
Science, 1 June 2001, p. 1716-1718
[Abstract] [Full Text]

Perspective: CELL BIOLOGY:
GGAs Tie Up the Loose Ends
Sharon A. Tooze
Science, 1 June 2001, p. 1663-1665
[Summary] [Full Text]

Crystal Structure of an Initiation Factor Bound to the 30S Ribosomal Subunit
A. P. Carter et al.
Science, 19 January 2001, p. 498-501
[Abstract] [Full Text]

Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease
Kim Orth et al.
Science, 24 November 2000, p. 1594-1597
[Abstract] [Full Text]

News: MICROBIOLOGY:
Unlocking the Secrets of the Grim Reaper
Kathryn Brown
Science, 24 November 2000, p. 1475
[Summary] [Full Text]

Selfish DNA in Protein-Coding Genes of Rickettsia
Hiroyuki Ogata et al.
Science, 13 October 2000, p. 347-350
[Abstract] [Full Text]

Structural Evidence for Evolution of the / Barrel Scaffold by Gene Duplication and Fusion
Dietmar Lang, Ralf Thoma, Martina Henn-Sax, Reinhard Sterner, and Matthias Wilmanns
Science, 1 September 2000, p. 1546-1550
[Abstract] [Full Text]

Perspective: PROTEIN EVOLUTION:
On the Ancestry of Barrels
Edith Wilson Miles and David R. Davies
Science, 1 September 2000, p. 1490
[Summary] [Full Text]

The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
Nenad Ban, Poul Nissen, Jeffrey Hansen, Peter B. Moore, and Thomas A. Steitz
Science, 11 August 2000, p. 905-920
[Abstract] [Full Text]

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
Poul Nissen, Jeffrey Hansen, Nenad Ban, Peter B. Moore, and Thomas A. Steitz
Science, 11 August 2000, p. 920-930
[Abstract] [Full Text]

A Single Adenosine with a Neutral pK_a in the Ribosomal Peptidyl Transferase Center
Gregory W. Muth, Lori Ortoleva-Donnelly, and Scott A. Strobel
Science, 11 August 2000, p. 947-950
[Abstract] [Full Text]

Perspective: STRUCTURAL BIOLOGY:
The Ribosome Is a Ribozyme
Thomas R. Cech
Science, 11 August 2000, p. 878-879
[Summary] [Full Text]

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
Krzysztof Palczewski et al.
Science, 4 August 2000, p. 739-745
[Abstract] [Full Text]

Cloning of the Arabidopsis Clock Gene TOC1, an Autoregulatory Response Regulator Homolog
Carl Strayer et al.
Science, 4 August 2000, p. 768-771
[Abstract] [Full Text]

Perspective: STRUCTURE:
Rhodopsin Sees the Light
Henry R. Bourne and Elaine C. Meng
Science, 4 August 2000, p. 733-734
[Summary] [Full Text]

One Sequence, Two Ribozymes: Implications for the Emergence of New Ribozyme Folds
Erik A. Schultes and David P. Bartel
Science, 21 July 2000, p. 448-452
[Abstract] [Full Text]

Perspective: RNA STRUCTURE:
Ribozyme Evolution at the Crossroads
Gerald F. Joyce
Science, 21 July 2000, p. 401-402
[Summary] [Full Text]

fw2.2: A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size
Anne Frary et al.
Science, 7 July 2000, p. 85-88
[Abstract] [Full Text]

Perspective: PLANT GENETICS:
A Tomato Gene Weighs In
John Doebley
Science, 7 July 2000, p. 71-72
[Summary] [Full Text]

A Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling
Francis Ka-Ming Chan et al.
Science, 30 June 2000, p. 2351-2354
[Abstract] [Full Text]

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
Richard M. Siegel et al.
Science, 30 June 2000, p. 2354-2357
[Abstract] [Full Text]

Perspective: SIGNAL TRANSDUCTION:
FasL Binds Preassembled Fas
Pierre Golstein
Science, 30 June 2000, p. 2328-2329
[Summary] [Full Text]

Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
Patrick Cramer et al.
Science, 28 April 2000, p. 640-649
[Abstract] [Full Text]

Perspective: STRUCTURAL BIOLOGY:
Light at the End of the Channel
Joan Weliky Conaway and Ronald C. Conaway
Science, 28 April 2000, p. 632-633
[Summary] [Full Text]

Viewpoint: From Sequence to Chromosome: The Tip of the X Chromosome of D. melanogaster
Panayiotis V. Benos et al.
Science, 24 March 2000, p. 2220-2222
[Abstract] [Full Text]

News: Structural Genomics Offers High-Speed Look at Proteins
Robert F. Service
Science, 17 March 2000, p. 1954-1956
[Summary] [Full Text]

Candidate Taste Receptors in Drosophila
Peter J. Clyne, Coral G. Warr, and John R. Carlson
Science, 10 March 2000, p. 1830-1834
[Abstract] [Full Text]

Molecular Architecture and Evolution of a Modular Spider Silk Protein Gene
Cheryl Y. Hayashi and Randolph V. Lewis
Science, 25 February 2000, p. 1477-1479
[Abstract] [Full Text]

News: MOLECULAR GENETICS:
Spider Genes Reveal Flexible Design
Erik Stokstad
Science, 25 February 2000, p. 1378
[Summary] [Full Text]

Crystal Structure of the Ribonucleoprotein Core of the Signal Recognition Particle
Robert T. Batey, Robert P. Rambo, Louise Lucast, Brian Rha, and Jennifer A. Doudna
Science, 18 February 2000, p. 1232-1239
[Abstract] [Full Text]

Perspective: STRUCTURAL BIOLOGY:
SRP--Where the RNA and Membrane Worlds Meet
Peter Walter, Robert Keenan, and Uli Schmitz
Science, 18 February 2000, p. 1212-1213
[Summary] [Full Text]

A Subclass of Ras Proteins That Regulate the Degradation of IB
Craig Fenwick et al.
Science, 4 February 2000, p. 869-873
[Abstract] [Full Text]

Genetic Definition and Sequence Analysis of Arabidopsis Centromeres
Gregory P. Copenhaver et al.
Science, 24 December 1999, p. 2468-2474
[Abstract] [Full Text]

X-ray Crystal Structures of 70S Ribosome Functional Complexes
Jamie H. Cate, Marat M. Yusupov, Gulnara Zh. Yusupova, Thomas N. Earnest, and Harry F. Noller
Science, 24 September 1999, p. 2095-2104
[Abstract] [Full Text]

Identification of an RNA-Protein Bridge Spanning the Ribosomal Subunit Interface
Gloria M. Culver, Jamie H. Cate, G. Zh. Yusupova, Marat M. Yusupov, and Harry F. Noller
Science, 24 September 1999, p. 2133-2135
[Abstract] [Full Text]

Perspective: STRUCTURE:
Function Is Structure
Anders Liljas
Science, 24 September 1999, p. 2077-2078
[Summary] [Full Text]

News: STRUCTURAL BIOLOGY:
The Race to the Ribosome Structure
Elizabeth Pennisi
Science, 24 September 1999, p. 2048-2051
[Summary] [Full Text]

Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex
Brian J. Hillier, Karen S. Christopherson, Kenneth E. Prehoda, David S. Bredt, and Wendell A. Lim
Science, 30 April 1999, p. 812-815
[Abstract] [Full Text]

Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
Charles E. Stebbins, William G. Kaelin Jr., and Nikola P. Pavletich
Science, 16 April 1999, p. 455-461
[Abstract] [Full Text]

Two Distinct Cytokines Released from a Human Aminoacyl-tRNA Synthetase
Keisuke Wakasugi and Paul Schimmel
Science, 2 April 1999, p. 147-151
[Abstract] [Full Text]

Perspective: EVOLUTION:
A Deadly Double Life
Alan M. Weiner and Nancy Maizels
Science, 2 April 1999, p. 63-64
[Summary] [Full Text]

Exon Shuffling by L1 Retrotransposition
John V. Moran, Ralph J. DeBerardinis, and Haig H. Kazazian Jr.
Science, 5 March 1999, p. 1530-1534
[Abstract] [Full Text]

Perspective: TRANSCRIPTION:
Exon Shuffling in Retrospect
Tom Eickbush
Science, 5 March 1999, p. 1465-1467
[Summary] [Full Text]

Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways
Neil D. Clarke, and Jeremy M. Berg
Science, 11 December 1998, pp. 2018-2022
[Abstract] [Full Text]

Segregation of Transcription and Replication Sites Into Higher Order Domains
Xiangyun Wei, Jagath Samarabandu, Rakendu S. Devdhar, Alan J. Siegel, Raj Acharya, and Ronald Berezney
Science, 4 September 1998, pp. 1502-1505
[Abstract] [Full Text]

Genetic Dissection of a Mammalian Replicator in the Human β-Globin Locus
Mirit I. Aladjem, Luo Wei Rodewald, John L. Kolman, and Geoffrey M. Wahl
Science, 14 August 1998, pp. 1005-1009
[Abstract] [Full Text]