Comprehensive Identification of Human bZIP Interactions with Coiled-Coil Arrays
John R. S. Newman and Amy E. Keating
Science, 27 June 2003, p. 2097-2101; published online June 12, 2003; 10.1126/science.1084648
[Abstract] [Full Text]

Characterization of Mammalian Selenoproteomes
Gregory V. Kryukov et al.
Science, 30 May 2003, p. 1439-1443
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
A View from the Top--Prion Diseases from 10,000 Feet
Suzette A. Priola, Bruce Chesebro, and Byron Caughey
Science, 9 May 2003, p. 917-919
[Summary] [Full Text]

Activation of Integrin IIbß3 by Modulation of Transmembrane Helix Associations
Renhao Li et al.
Science, 2 May 2003, p. 795-798
[Abstract] [Full Text]

Perspective: STRUCTURAL BIOLOGY:
Changing Partners
Richard O. Hynes
Science, 2 May 2003, p. 755-756
[Summary] [Full Text]

Review: Assembly of Cell Regulatory Systems Through Protein Interaction Domains
Tony Pawson and Piers Nash
Science, 18 April 2003, p. 445-452
[Abstract] [Full Text]

Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates
Andrew E. H. Elia, Lewis C. Cantley, and Michael B. Yaffe
Science, 21 February 2003, p. 1228-1231
[Abstract] [Full Text]

Perspective: SIGNAL TRANSDUCTION:
Capturing Polo Kinase
Herman H. W. Silljé and Erich A. Nigg
Science, 21 February 2003, p. 1190-1191
[Summary] [Full Text]

Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms
Sang-Hyun Park, Ali Zarrinpar, and Wendell A. Lim
Science, 14 February 2003, p. 1061-1064; published online January 2, 2003; 10.1126/science.1076979
[Abstract] [Full Text]

Perspective: SIGNAL TRANSDUCTION:
Imposing Specificity on Kinases
Mark Ptashne and Alexander Gann
Science, 14 February 2003, p. 1025-1027
[Summary] [Full Text]

Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation
Victoria Yankovskaya et al.
Science, 31 January 2003, p. 700-704
[Abstract] [Full Text]

Perspective: STRUCTURAL BIOLOGY:
Complex II Is Complex Too
Lars Hederstedt
Science, 31 January 2003, p. 671-672
[Summary] [Full Text]

Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum
Bernardo J. Foth et al.
Science, 31 January 2003, p. 705-708
[Abstract] [Full Text]

Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics
Per Hammarström, R. Luke Wiseman, Evan T. Powers, and Jeffery W. Kelly
Science, 31 January 2003, p. 713-716
[Abstract] [Full Text]

Selective Trafficking of Non-Cell-Autonomous Proteins Mediated by NtNCAPP1
Jung-Youn Lee et al.
Science, 17 January 2003, p. 392-396
[Abstract] [Full Text]

Role of Anthocyanidin Reductase, Encoded by BANYULS in Plant Flavonoid Biosynthesis
De-Yu Xie, Shashi B. Sharma, Nancy L. Paiva, Daneel Ferreira, and Richard A. Dixon
Science, 17 January 2003, p. 396-399
[Abstract] [Full Text]

Endoproteolytic Activity of the Proteasome
Chang-Wei Liu, Michael J. Corboy, George N. DeMartino, and Philip J. Thomas
Science, 17 January 2003, p. 408-411; published online December 12, 2002; 10.1126/science.1079293
[Abstract] [Full Text]

Distinctive Roles of PHAP Proteins and Prothymosin- in a Death Regulatory Pathway
Xuejun Jiang et al.
Science 10 January 2003, p. 223-226. [Abstract] [Full Text]

Perspective: APOPTOSIS:
Life and Death Decisions
Donald W. Nicholson and Nancy A. Thornberry
Science, 10 January 2003, p. 214-215
[Summary] [Full Text]

Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk
Farhad Abtahian et al.
Science, 10 January 2003, p. 247-251
[Abstract] [Full Text]

Perspective: DEVELOPMENT:
Lymphatics Make the Break
Rakesh K. Jain and Timothy P. Padera
Science, 10 January 2003, p. 209-210
[Summary] [Full Text]

Coordinated Nonvectorial Folding in a Newly Synthesized Multidomain Protein
Annemieke Jansens, Esther van Duijn, and Ineke Braakman
Science, 20 December 2002, p. 2401-2403
[Abstract] [Full Text]

Experimental Identification of Downhill Protein Folding
Maria M. Garcia-Mira, Mourad Sadqi, Niels Fischer, Jose M. Sanchez-Ruiz, and Victor Muñoz
Science, 13 December 2002, p. 2191-2195
[Abstract] [Full Text]

Review: The Protein Kinase Complement of the Human Genome
G. Manning, D. B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam
Science, 6 December 2002, p. 1912-1934
[Abstract] [Full Text]

Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum
Sarah K. Volkman et al.
Science, 4 October 2002, p. 216-218
[Abstract] [Full Text]

A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells
George H. Patterson and Jennifer Lippincott-Schwartz
Science, 13 September 2002, p. 1873-1877
[Abstract] [Full Text]

Structure, Mechanism, and Regulation of the Neurospora Plasma Membrane H⁺-ATPase
Werner Kühlbrandt, Johan Zeelen, and Jens Dietrich
Science, 6 September 2002, p. 1692-1696; published online August 8, 2002; 10.1126/science.1072574
[Abstract] [Full Text]

Cooperation of GGAs and AP-1 in Packaging MPRs at the Trans-Golgi Network
Balraj Doray, Pradipta Ghosh, Janice Griffith, Hans J. Geuze, and Stuart Kornfeld
Science, 6 September 2002, p. 1700-1703
[Abstract] [Full Text]

Inhibition of Retroviral RNA Production by ZAP, a CCCH-Type Zinc Finger Protein
Guangxia Gao, Xuemin Guo, and Stephen P. Goff
Science, 6 September 2002, p. 1703-1706
[Abstract] [Full Text]

The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism
Kaspar P. Locher, Allen T. Lee, and Douglas C. Rees
Science, 10 May 2002, p. 1091-1098
[Abstract] [Full Text]

Perspective: STRUCTURAL BIOLOGY:
Not Just Another ABC Transporter
Amy L. Davidson
Science, 10 May 2002, p. 1038-1040
[Summary] [Full Text]

Specificity and Stability in Topology of Protein Networks
Sergei Maslov and Kim Sneppen
Science, 3 May 2002, p. 910-913
[Abstract] [Full Text]

Multicolor and Electron Microscopic Imaging of Connexin Trafficking
Guido Gaietta et al.
Science, 19 April 2002, p. 503-507
[Abstract] [Full Text]

Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis
Sena J. Lee et al.
Science, 8 March 2002, p. 1898-1901
[Abstract] [Full Text]

Long-Range Interactions Within a Nonnative Protein
Judith Klein-Seetharaman et al.
Science, 1 March 2002, p. 1719-1722
[Abstract] [Full Text]

Perspective: PROTEIN FOLDING:
Making a Network of Hydrophobic Clusters
Robert L. Baldwin
Science, 1 March 2002, p. 1657-1658
[Summary] [Full Text]

A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules
Amy Hin Yan Tong et al.
Science, 11 January 2002, p. 321-324; published online December 13, 2001, 10.1126/science.1064987
[Abstract] [Full Text]

Perspective: PROTEOMICS:
Integrating Interactomes
Mark Gerstein, Ning Lan, and Ronald Jansen
Science, 11 January 2002, p. 284-287
[Summary] [Full Text]

Global Analysis of Protein Activities Using Proteome Chips
Heng Zhu et al.
Science, 14 September 2001, p. 2101-2105
[Abstract] [Full Text]

Gene Families from the Arabidopsis thaliana Pollen Coat Proteome
Jacob A. Mayfield, Aretha Fiebig, Sarah E. Johnstone, and Daphne Preuss
Science, 29 June 2001, p. 2482-2486
[Abstract] [Full Text]

Future Directions: Proteomics in Genomeland
Stanley Fields
Science, 16 February 2001, p. 1221-1224
[Summary] [Full Text]

Genome-Wide Location and Function of DNA Binding Proteins
B. Ren et al.
Science, 22 December 2000, p. 2306-2309
[Abstract] [Full Text]

Printing Proteins as Microarrays for High-Throughput Function Determination
Gavin MacBeath and Stuart L. Schreiber
Science, 8 September 2000, p. 1760-1763
[Abstract] [Full Text]

News: BIOCHEMISTRY:
Protein Arrays Step Out of DNA's Shadow
Robert F. Service
Science, 8 September 2000, p. 1673
[Summary] [Full Text]

Designing Small-Molecule Switches for Protein-Protein Interactions
Zhihong Guo, Demin Zhou, and Peter G. Schultz
Science, 16 June 2000, p. 2042-2045
[Abstract] [Full Text]

Creating a Protein-Based Element of Inheritance
Liming Li and Susan Lindquist
Science, 28 January 2000, p. 661-664
[Abstract] [Full Text]

News: CELL BIOLOGY:
Generating New Yeast Prions
Michael Balter
Science, 28 January 2000, p. 562-563
[Summary] [Full Text]

Protein Interaction Mapping in C. elegans Using Proteins Involved in Vulval Development
Albertha J. M. Walhout et al.
Science, 7 January 2000, p. 116-122
[Abstract] [Full Text]

Perspective: BIOCHEMISTRY:
Reading the Worm Genome
Stuart K. Kim
Science, 7 January 2000, p. 52-53
[Summary] [Full Text]

Evolutionarily Conserved Pathways of Energetic Connectivity in Protein Families
Steve W. Lockless and Rama Ranganathan
Science, 8 October 1999, p. 295-299
[Abstract] [Full Text]

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences
Edward M. Marcotte et al.
Science, 30 July 1999, p. 751-753
[Abstract] [Full Text]

Genetic Selection of Peptide Inhibitors of Biological Pathways
Thea C. Norman et al.
Science, 23 July 1999, p. 591-595
[Abstract] [Full Text]

Tech.Sight: PROTEIN BIOCHEMISTRY:
Protein Interaction Methods-Toward an Endgame
Andrew R. Mendelsohn and Roger Brent
Science, 18 June 1999, p. 1948-1950
[Summary] [Full Text]

Tech.Sight: BIOCHEMISTRY:
Biomolecule Mass Spectrometry
Fred W. McLafferty, Einar K. Fridriksson, David M. Horn, Mark A. Lewis, and Roman A. Zubarev
Science, 21 May 1999, p. 1289-1290
[Summary] [Full Text]

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules
Pei-Jung Lu, Xiao Zhen Zhou, Minhui Shen, and Kun Ping Lu
Science, 26 February 1999, p. 1325-1328
[Abstract] [Full Text]

News: CELL BIOLOGY:
New Clues to How Proteins Link Up to Run the Cell
Marcia Barinaga
Science, 26 February 1999, p. 1247-1249
[Summary] [Full Text]

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade
Hans J. Schaeffer, Andrew D. Catling, Scott T. Eblen, Lara S. Collier, Anke Krauss, Michael J. Weber
Science, 11 September 1998, pp. 1668-1671
[Abstract] [Full Text]

A Family of cAMP-Binding Proteins That Directly Activate Rap1
Hiroaki Kawasaki, et al.
Science, 18 December 1998, pp. 2275-2279
[Abstract] [Full Text]

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
Alan J. Whitmarsh, Julie Cavanagh, Cathy Tournier, Jun Yasuda, Roger J. Davis
Science, 11 September 1998, pp. 1671-1674
[Abstract] [Full Text]

Perspectives: SIGNAL TRANSDUCTION:
Routing MAP Kinase Cascades
Elaine A. Elion
Science, 11 September 1998, p. 1625-1626
[Summary] [Full Text]

Pathways to a Protein Folding Intermediate Observed in a 1-Microsecond Simulation in Aqueous Solution
Yong Duan and Peter A. Kollman
Science, 23 October 1998, pp. 740-744
[Abstract] [Full Text]

Perspectives: PROTEIN FOLDING:
A Glimpse of the Holy Grail?
Herman J. C. Berendsen
Science, 23 October 1998, pp. 642-643
[Summary] [Full Text]

Structure and Asn-Pro-Phe Binding Pocket of the Eps15 Homology Domain
Tonny de Beer, Royston E. Carter, Katherine E. Lobel-Rice, Alexander Sorkin, and Michael Overduin
Science, 28 August 1998, pp. 1357-1360
[Abstract] [Full Text]

Gene Families: The Taxonomy of Protein Paralogs and Chimeras
Steven Henikoff, Elizabeth A. Greene, Shmuel Pietrokovski, Peer Bork, Teresa K. Attwood, and Leroy Hood
Science, 24 October 1997, pp. 609-614
[Abstract] [Full Text]

A Genomic Perspective on Protein Families
Roman L. Tatusov, Eugene V. Koonin, and David J. Lipman
Science, 24 October 1997, pp. 631-637
[Abstract] [Full Text]