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Science Functional Genomics
Research

Gene and Genome Technologies




General Topics

Brevia: PCR in a Rayleigh-Bénard Convection Cell
Madhavi Krishnan, Victor M. Ugaz, and Mark A. Burns
Science, 25 October 2002, p. 793
[Full Text]

Direct Patterning of Modified Oligonucleotides on Metals and Insulators by Dip-Pen Nanolithography
L. M. Demers, D. S. Ginger, S.-J. Park, Z. Li, S.-W. Chung, C. A. Mirkin
Science, 7 June 2002, p. 1836-1838
[Abstract] [Full Text]

Probing Protein Electrostatics with a Synthetic Fluorescent Amino Acid
Bruce E. Cohen et al.
Science, 31 May 2002, p. 1700-1703
[Abstract] [Full Text]

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays
Tyson A. Clark, Charles W. Sugnet, and Manuel Ares Jr.
Science, 3 May 2002, p. 907-910
[Abstract] [Full Text]

Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies
James Sharpe et al.
Science, 19 April 2002, p. 541-545
[Abstract] [Full Text]

Self-Assembled Magnetic Matrices for DNA Separation Chips
Patrick S. Doyle et al.
Science, 22 March 2002, p. 2237
[Full Text]

Protein Nanoarrays Generated By Dip-Pen Nanolithography
Ki-Bum Lee et al.
Science, 1 March 2002, p. 1702-1705; published online February 7, 2002, 10.1126/science.1067172
[Abstract] [Full Text]

Array-Based Electrical Detection of DNA with Nanoparticle Probes
So-Jung Park, T. Andrew Taton, and Chad A. Mirkin
Science, 22 February 2002, p. 1503-1506
[Abstract] [Full Text]

News: ANALYTICAL CHEMISTRY:
New Test Could Speed Bioweapon Detection

Robert F. Service
Science, 22 February 2002, p. 1447
[Summary] [Full Text]

Expanding the Genetic Code of Escherichia coli
L. Wang, A. Brock, B. Herberich, P. G. Schultz
Science, 20 April 2001, p. 498-501
[Abstract] [Full Text]

Enlarging the Amino Acid Set of Escherichia coli by Infiltration of the Valine Coding Pathway
V. Döring et al.
Science, 20 April 2001, p. 501-504
[Abstract] [Full Text]

Perspective: MOLECULAR BIOLOGY:
Invading the Genetic Code

A. Böck
Science, 20 April 2001, p. 453-454
[Summary] [Full Text]

Future Directions: Making Sense of the Sequence
David J. Galas
Science, 16 February 2001, p. 1257-1260
[Abstract] [Full Text]

Separation of Long DNA Molecules in a Microfabricated Entropic Trap Array
J. Han and H. G. Craighead
Science, 12 May 2000, p. 1026-1029
[Abstract] [Full Text]

Viewpoint: A Drosophila Complementary DNA Resource
Gerald M. Rubin et al.
Science, 24 March 2000, p. 2222-2224
[Abstract] [Full Text]

Review: A Whole-Genome Assembly of Drosophila
Eugene W. Myers et al.
Science, 24 March 2000, p. 2196-2204
[Abstract] [Full Text]

Tech.Sight: MOLECULAR BIOLOGY:
Bead-based Fiber-Optic Arrays

David R. Walt
Science, 21 January 2000, p. 451-452
[Summary] [Full Text]

A Biochemical Genomics Approach for Identifying Genes by the Activity of Their Products
Mark R. Martzen et al.
Science, 5 November 1999, p. 1153-1155
[Abstract] [Full Text]

Tech.Sight: MOLECULAR GENETICS:
MaRX: An Approach to Genetics in Mammalian Cells

Gregory J. Hannon et al.
Science, 19 February 1999, p. 1129-1130
[Summary] [Full Text]

A Physical Map of 30,000 Human Genes
P. Deloukas et al.
Science, 23 October 1998, pp. 744-746
[Abstract] [Full Text]

An Arabidopsis Mutant Defective in the Plastid General Protein Import Apparatus
Paul Jarvis, Lih-Jen Chen, Hsou-min Li, Charles A. Peto, Christian Fankhauser, and Joanne Chory
Science, 2 October 1998, pp. 100-103
[Abstract] [Full Text]

 




Sequencing Technologies

Tech.Sight: TECHVIEW:SEQUENCING
Gels and Genomes

Jane Rogers
Science, 15 October 1999, p. 429
[Summary] [Full Text]

Tech.Sight: DNA SEQUENCING:
Sequencing the Genome, Fast

James C. Mullikin and Amanda A. McMurray
Science, 19 March 1999, p. 1867-1868
[Summary] [Full Text]

Tech.Sight: SOFTWARE:
All-in-One Sequence Analysis

Indira Rajagopal
Science, 29 January 1999, p. 652-653
[Summary] [Full Text]

An Integrated Nanoliter DNA Analysis Device
Mark A. Burns et al.
Science, 16 October 1998, pp. 484-487
[Abstract] [Full Text]

News: LABS ON A CHIP:
Coming Soon: The Pocket DNA Sequencer

Evelyn Strauss
Science, 16 October 1998, pp. 399-401
[Summary] [Full Text]

Viewpoint: Sequencing the Human Genome
Lee Rowen, Gregory Mahairas, and Leroy Hood
Science, 24 October 1997, pp. 605-607
[Abstract] [Full Text]

 




Sequence Scanning/Bioinformatics

Future Directions: Bioinformatics--Trying to Swim in a Sea of Data
David S. Roos
Science, 16 February 2001, p. 1260-1261
[Abstract] [Full Text]

Scanometric DNA Array Detection with Nanoparticle Probes
T. Andrew Taton, Chad A. Mirkin, and Robert L. Letsinger
Science, 8 September 2000, p. 1757-1760
[Abstract] [Full Text]

Letter: Help in Accessing Human Genome Information
The International Human Genome Sequencing Consortium
Science, 1 September 2000, p. 1471
[Full Text]

Tech.Sight: COMPUTERS AND BIOLOGY:
Bioinformatics in the Information Age

Sylvia J. Spengler
Science, 18 February 2000, p. 1221-1223
[Summary] [Full Text]

Viewpoint: Biosequence Exegesis
Mark S. Boguski
Science, 15 October 1999, p. 453-455
[Abstract] [Full Text]

A Computational Screen for Methylation Guide snoRNAs in Yeast
Todd M. Lowe and Sean R. Eddy
Science, 19 February 1999, p. 1168-1171
[Abstract] [Full Text]

Viewpoint: Databases in Genomic Research
W. M. Gelbart
Science, 23 October 1998, p. 659-662
[Abstract] [Full Text]

 




Gene Targeting

Brevia: Chimeric Nucleases Stimulate Gene Targeting in Human Cells
Matthew H. Porteus and David Baltimore
Science, 2 May 2003, p. 763
[Full Text]

Brevia: Enhancing Gene Targeting with Designed Zinc Finger Nucleases
Marina Bibikova, Kelly Beumer, Jonathan K. Trautman, and Dana Carroll
Science, 2 May 2003, p. 764
[Full Text]

Specific Mutations Induced by Triplex-Forming Oligonucleotides in Mice
Karen M. Vasquez, Latha Narayanan, and Peter M. Glazer
Science, 20 October 2000, p. 530-533
[Abstract] [Full Text]

Suppression of Mutations in Mitochondrial DNA by tRNAs Imported from the Cytoplasm
O. A. Kolesnikova et al.
Science, 15 September 2000, p. 1931-1933
[Abstract] [Full Text]

Group II Introns Designed to Insert into Therapeutically Relevant DNA Target Sites in Human Cells
Huatao Guo et al.
Science, 21 July 2000, p. 452-457
[Abstract] [Full Text]

News: MOLECULAR BIOLOGY:
Targeting Intron Insertion Into DNA

Evelyn Strauss
Science, 21 July 2000, p. 374
[Summary] [Full Text]

Figure 1

 

Gene Targeting by Homologous Recombination in Drosophila
Yikang S. Rong and Kent G. Golic
Science, 16 June 2000, p. 2013-2018
[Abstract] [Full Text]

Perspective: GENETICS:
Reversal of Fortune for Drosophila Geneticists?

William R. Engels
Science, 16 June 2000, p. 1973-1975
[Summary] [Full Text]

Technical Comment: Gene Targeting in Human Cells Without Isogenic DNA
John M. Sedivy, Bert Vogelstein, Howard L. Liber, Eric A. Hendrickson, and Alan Rosmarin
Science, 1 January 1999, p. 9
[Abstract] [Full Text]

 




Genetic Analysis

Review: Genetics and the Specificity of the Aging Process
Siegfried Hekimi and Leonard Guarente
Science, 28 February 2003, p. 1351-1354
[Abstract] [Full Text]

Brevia: Long-Range Paternal Gene Flow in the Southern Elephant Seal
Anna Fabiani, A. Rus Hoelzel, Filippo Galimberti, and Monica M. C. Muelbert
Science, 31 January 2003, p. 676
[Full Text]

Genetic Evidence for Local Retention of Pelagic Larvae in a Caribbean Reef Fish
Michael S. Taylor and Michael E. Hellberg
Science, 3 January 2003, p. 107-109
[Abstract] [Full Text]

Perspective: ECOLOGY:
Why Gobies Are Like Hobbits

Stephen R. Palumbi and Robert R. Warner
Science, 3 January 2003, p. 51-52
[Summary] [Full Text]

Review: Finding Genes That Underlie Complex Traits
Anne M. Glazier, Joseph H. Nadeau, and Timothy J. Aitman
Science, 20 December 2002, p. 2345-2349
[Abstract] [Full Text]

Inversions and Gene Order Shuffling in Anopheles gambiae and A. funestus
Igor V. Sharakhov et al.
Science, 4 October 2002, p. 182-185
[Abstract] [Full Text]

Target-Selected Inactivation of the Zebrafish rag1 Gene
E. Wienholds, S. Schulte-Merker, B. Walderich, R.H.A. Plasterk
Science, 5 July 2002, p. 105-107
[Abstract] [Full Text]

Combinatorial Synthesis of Genetic Networks
Calin C. Guet, Michael B. Elowitz, Weihong Hsing, and Stanislas Leibler
Science, 24 May 2002, p. 1466-1470
[Abstract] [Full Text]

Perspective: GENETICS:
Wild by Nature

Michael Wigler and Bud Mishra
Science, 24 May 2002, p. 1407-1408
[Summary] [Full Text]

Genetic Correlates of Musical Pitch Recognition in Humans
D. Drayna, A. Manichaikul, M. de Lange, H. Snieder, T. Spector
Science, 9 March 2001, p. 1969-1972
[Abstract] [Full Text]

News: BEHAVIORAL GENETICS:
Study Suggests Pitch Perception Is Inherited

Constance Holden
Science, 9 March 2001, p. 1879
[Summary] [Full Text]

Genetics of Mouse Behavior: Interactions with Laboratory Environment
John C. Crabbe, Douglas Wahlsten, and Bruce C. Dudek
Science, 4 June 1999, p. 1670-1672
[Abstract] [Full Text]

News: BEHAVIORAL GENETICS:
Fickle Mice Highlight Test Problems

Martin Enserink
Science, 4 June 1999, p. 1599-1600
[Summary] [Full Text]

Tracking the Long-Term Decline and Recovery of an Isolated Population
Ronald L. Westemeier et al.
Science, 27 November 1998, pp. 1695-1698
[Abstract] [Full Text]

Perspectives: POPULATION GENETICS:
No Need to Isolate Genetics

Michael E. Soulé and L. Scott Mills
Science, 27 November 1998, pp. 1658-1659
[Summary] [Full Text]

Direct Allelic Variation Scanning of the Yeast Genome
Elizabeth A. Winzeler et al.
Science, 21 August 1998, pp. 1194-1197
[Abstract] [Full Text]

News: GENOMICS:
DNA Chips Survey an Entire Genome

Robert F. Service
Science, 21 August 1998, p. 1122
[Summary] [Full Text]

 




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