Disease-Associated Genes
Gene Therapy
Genetic Testing
DNA Vaccines
Other Applications

Brevia: Lamin A Truncation in Hutchinson-Gilford Progeria
Annachiara De Sandre-Giovannoli et al.
Science, 27 June 2003, p. 2055; published online April 17, 2003; 10.1126/science.1084125
[Full Text]

Coronavirus Main Proteinase (3CL^pro) Structure: Basis for Design of Anti-SARS Drugs
Kanchan Anand, John Ziebuhr, Parvesh Wadhwani, Jeroen R. Mesters, and Rolf Hilgenfeld
Science, 13 June 2003, p. 1763-1767; published online May 13, 2003; 10.1126/science.1085658
[Abstract] [Full Text]

Brevia: Hypermutation of HIV-1 DNA in the Absence of the Vif Protein
Denise Lecossier, Francine Bouchonnet, François Clavel, and Allan J. Hance
Science, 16 May 2003, p. 1112
[Full Text]

Brevia: Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers
Alberto Bardelli et al.
Science, 9 May 2003, p. 949
[Full Text]

Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport
Majid Hafezparast et al.
Science, 2 May 2003, p. 808-812
[Abstract] [Full Text]

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency
Capucine Picard et al.
Science, 28 March 2003, p. 2076-2079; published online March 13, 2003; 10.1126/science.1081902
[Abstract] [Full Text]

Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban
Joachim P. Schmitt et al.
Science, 28 February 2003, p. 1410-1413
[Abstract] [Full Text]

Myc-Induced T Cell Leukemia in Transgenic Zebrafish
David M. Langenau et al.
Science, 7 February 2003, p. 887-890
[Abstract] [Full Text]

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors
Michael C. Heinrich et al.
Science, 31 January 2003, p. 708-710; published online January 9, 2003; 10.1126/science.1079666
[Abstract] [Full Text]

Spongiform Degeneration in mahoganoid Mutant Mice
Lin He et al.
Science, 31 January 2003, p. 710-712
[Abstract] [Full Text]

KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation
Yi-Han Chen et al.
Science, 10 January 2003, p. 251-254
[Abstract] [Full Text]

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati et al.
Science, 10 January 2003, p. 256-259; published online November 21, 2002; 10.1126/science.1077209
[Abstract] [Full Text]

Dyskeratosis Congenita and Cancer in Mice Deficient in Ribosomal RNA Modification
Davide Ruggero et al.
Science, 10 January 2003, p. 259-262
[Abstract] [Full Text]

Drosophila BLM in Double-Strand Break Repair by Synthesis-Dependent Strand Annealing
Melissa D. Adams, Mitch McVey, and Jeff J. Sekelsky
Science, 10 January 2003, p. 265-267
[Abstract] [Full Text]

Truncating Neurotrypsin Mutation in Autosomal Recessive Nonsyndromic Mental Retardation
Florence Molinari et al.
Science, 29 November 2002, p. 1779-1781
[Abstract] [Full Text]

Perspective: CANCER BIOLOGY:
A Matter of Dosage
Riccardo Fodde and Ron Smits
Science, 25 October 2002, p. 761-763
[Summary] [Full Text]

Structural Basis for Gluten Intolerance in Celiac Sprue
Lu Shan et al.
Science, 27 September 2002, p. 2275-2279
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Gluten and the Gut--Lessons for Immune Regulation
Detlef Schuppan and Eckhart G. Hahn
Science, 27 September 2002, p. 2218-2220
[Summary] [Full Text]

News: AIDS RESEARCH:
Mystery Anti-HIV Factor Unmasked?
Jon Cohen
Science, 27 September 2002, p. 2188
[Summary] [Full Text]

Brevia: BLM Heterozygosity and the Risk of Colorectal Cancer
Stephen B. Gruber et al.
Science, 20 September 2002, p. 2013
[Full Text]

Enhanced Tumor Formation in Mice Heterozygous for Blm Mutation
Kathleen Heppner Goss et al.
Science, 20 September 2002, p. 2051-2053
[Abstract] [Full Text]

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure
Haijuan Yang et al.
Science, 13 September 2002, p. 1837-1848
[Abstract] [Full Text]

Perspective: CANCER:
BRCA2 Enters the Fray
John H. Wilson and Stephen J. Elledge
Science, 13 September 2002, p. 1822-1823
[Summary] [Full Text]

Variant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia
Igor Splawski et al.
Science, 23 August 2002, p. 1333-1336
[Abstract] [Full Text]

News: PHARMACOGENETICS:
Gene Mutation May Boost Risk of Heart Arrhythmias
Jean Marx
Science, 23 August 2002, p. 1252
[Summary] [Full Text]

Biallelic Inactivation of BRCA2 in Fanconi Anemia
Niall G. Howlett et al.
Science, 26 July 2002, pp. 606-609; published online June 13, 2002, 10.1126/science.1073834
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
D-Day for BRCA2
Emily Witt and Alan Ashworth
Science, 26 July 2002, pp. 534; published online June 13, 2002, 10.1126/science.1074482
[Summary] [Full Text]

Identification of Bphs, an Autoimmune Disease Locus, as Histamine Receptor H₁
Runlin Z. Ma et al.
Science, 26 July 2002, pp. 620-623
[Abstract] [Full Text]

Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice
C.B. Millar, J. Guy, O.J. Sansom, J. Selfridge, E. MacDougall, B. Hendrich, P.D. Keightley, S.M. Bishop, A.R. Clarke, A. Bird
Science, 19 July 2002, pp. 403-405
[Abstract] [Full Text]

Perspective: PARASITOLOGY:
Drugs to Combat Tropical Protozoan Parasites
M.H. Gelb and W.G.J. Hol
Science, 19 July 2002, pp. 343-344
[Summary] [Full Text]

Perspective: PARASITOLOGY:
Malaria -- from Infants to Genomics to Vaccines
C.A. Long and S.L. Hoffman
Science, 19 July 2002, pp. 345-347
[Summary] [Full Text]

An Essential Role of N-Terminal Arginylation in Cardiovascular Development
Y.T. Kwon, A.S. Kashina, I.V. Davydov, R.-G. Hu, J.Y. An, J.W. Seo, F. Du, A. Varshavsky
Science, 5 July 2002, pp. 96-99
[Abstract] [Full Text]

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
C. Arvanitis, K. Chu, W. Dewey, E. Leonhardt, M. Trinh, C.D. Sundberg, J.M. Bishop, D.W. Felsher
Science, 5 July 2002, p. 102-104
[Abstract] [Full Text]

Perspective: CANCER:
Addition to Oncogenes -- the Achilles Heal of Cancer
I.B. Weinstein
Science, 5 July 2002, pp. 63-64
[Summary] [Full Text]

Review: Diversity Considerations in HIV-1 Vaccine Selection
B. Gaschen, J. Taylor, K. Yusim, B. Foley, F. Gao, D. Lang, V. Novitsky, B. Haynes, B.H. Hahn, T. Bhattacharya, B. Korber
Science, 28 June 2001, p. 2354-2360
[Abstract] [Full Text]

AGTR2 Mutations in X-Linked Mental Retardation
V.S. Vervoort, M.A. Beachem, P.S. Edwards, S. Ladd, K.E. Miller, X. de Mollerat, K. Clarkson, B. DuPont, C.E. Schwartz, R.E. Stevenson, E. Boyd, A.K. Srivastava
Science, 28 June 2002, p. 2401-2403
[Abstract] [Full Text]

Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease
Anthone W. Dunah et al.
Science, 21 June 2002, pp. 2238-2243; published online May 2, 2002, 10.1126/science.1072613
[Abstract] [Full Text]

Perspective: NEURODEGENERATION:
A Glutamine-Rich Trail Leads to Transcription Factors
Richard N. Freiman and Robert Tjian
Science, 21 June 2002, pp. 2149-2150
[Summary] [Full Text]

Biallelic Inactivation of BRCA2 in Fanconi Anemia
Niall G. Howlett et al.
Science, published online June 13, 2002, Science 10.1126/science.1073834
[Abstract]

Review: Toxic Proteins in Neurodegenerative Disease
J. Paul Taylor, John Hardy, and Kenneth H. Fischbeck
Science, 14 June 2002, p. 1991-1995
[Abstract] [Full Text]

Female Germ Cell Aneuploidy and Embryo Death in Mice Lacking the Meiosis-Specific Protein SCP3
Li Yuan et al.
Science, 10 May 2002, p. 1115-1118
[Abstract] [Full Text]

Autosomal Dominant Mutations Affecting X Inactivation Choice in the Mouse
Ivona Percec, Robert M. Plenge, Joseph H. Nadeau, Marisa S. Bartolomei, and Huntington F. Willard
Science, 10 May 2002, p. 1136-1139
[Abstract] [Full Text]

Enhanced and Delayed Stress-Induced Alcohol Drinking in Mice Lacking Functional CRH1 Receptors
Inge Sillaber et al.
Science, 3 May 2002, p. 931-933
[Abstract] [Full Text]

News: ALCOHOLISM RESEARCH:
Stressed Mutant Mice Hit the Bottle
Constance Holden
Science, 3 May 2002, p. 823-824
[Summary] [Full Text]

Viewpoint: Balancing Life-Style and Genomics Research for Disease Prevention
Walter C. Willett
Science, 26 April 2002, p. 695-698
[Abstract] [Full Text]

Viewpoint: Maneuvering in the Complex Path from Genotype to Phenotype
Richard Strohman
Science, 26 April 2002, p. 701-703
[Abstract] [Full Text]

Review: Schizophrenia: Diverse Approaches to a Complex Disease
Akira Sawa and Solomon H. Snyder
Science, 26 April 2002, p. 692-695
[Abstract] [Full Text]

No Major Schizophrenia Locus Detected on Chromosome 1q in a Large Multicenter Sample
Douglas F. Levinson et al.
Science, 26 April 2002, p. 739-741
[Abstract] [Full Text]

Purkinje cell degeneration (pcd) Phenotypes Caused by Mutations in the Axotomy-Induced Gene, Nna1
Angeles Fernandez-Gonzalez et al.
Science, 8 March 2002, p. 1904-1906
[Abstract] [Full Text]

Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Anna Velcich et al.
Science, 1 March 2002, p. 1726-1729
[Abstract] [Full Text]

Effect of p53 Status on Tumor Response to Antiangiogenic Therapy
Joanne L. Yu et al.
Science, 22 February 2002, p. 1526-1528
[Abstract] [Full Text]

News: CANCER RESEARCH:
Obstacle for Promising Cancer Therapy
Jean Marx
Science, 22 February 2002, p. 1444
[Summary] [Full Text]

Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin
Tayebeh Rezaie et al.
Science, 8 February 2002, p. 1077-1079
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Under Pressure
James S. Friedman and Michael A. Walter
Science, 8 February 2002, p. 983-984
[Summary] [Full Text]

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet
Susetta Finotto et al.
Science, 11 January 2002, p. 336-338
[Abstract] [Full Text]

Distinct Effects of T-bet in T_H1 Lineage Commitment and IFN-g Production in CD4 and CD8 T Cells
Susanne J. Szabo et al.
Science, 11 January 2002, p. 338-342
[Abstract] [Full Text]

News: ASTHMA RESEARCH:
Missing Gene Takes Mice's Breath Away
Gretchen Vogel
Science, 11 January 2001, p. 253
[Summary] [Full Text]

KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer
Goutham Narla et al.
Science, 21 December 2001, p. 2563-2566
[Abstract] [Full Text]

Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo
Matthias Groszer et al.
Science, 7 December 2001, pp. 2186-2189
[Abstract] [Full Text]

Perspective: STEM CELLS:
PTEN--Coupling Tumor Suppression to Stem Cells?
Josef M. Penninger and James Woodgett
Science, 7 December 2001, pp. 2116-2118
[Summary] [Full Text]

A Phosphatase Associated with Metastasis of Colorectal Cancer
Saurabh Saha et al.
Science, 9 November 2001, pp. 1343-1346
[Abstract] [Full Text]

Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice
A. Ylikorkala et al.
Science, 17 August 2001, p. 1323-1327
[Abstract] [Full Text]

Human Hypertension Caused by Mutations in WNK Kinases
F. H. Wilson et al.
Science, 10 August 2001, p. 1107-1111
[Abstract] [Full Text]

Myotonic Dystrophy Type 2 Caused by a CCTG Expansion in Intron 1 of ZNF9
C. L. Liquori et al.
Science, 3 August 2001, p. 864-868
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Reconstructing Myotonic Dystrophy
S. J. Tapscott and C. A. Thornton
Science, 3 August 2001, p. 816-818
[Summary] [Full Text]

Clinical Resistance to STI-571 Cancer Therapy Causted by BCR-ABL Gene Mutation or Amplification
M. E. Gorre et al.
Science, 3 August 2001, p. 876-880
[Abstract] [Full Text]

Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles
C. Wittmann et al.
Science, 27 Jul 2001, p. 711-714
[Abstract] [Full Text]

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
C. Zuccato et al.
Science, 20 Jul 2001, p. 493-498
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Huntington--Profit and Loss
Y. Trottier and J. L. Mandel
Science, 20 Jul 2001, p. 445-446
[Summary] [Full Text]

Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance
Sarah A. Tishkoff et al.
Science, 20 Jul 2001, p. 455-462
[Abstract] [Full Text]

Perspective: MALARIA:
Protecting Against Bad Air
L. Luzzatto and R. Notaro
Science, 20 Jul 2001, p. 442-443
[Summary] [Full Text]

Recent Origin of Plasmodium falciparum from a Single Progenitor
Sarah K. Volkman et al.
Science, 20 Jul 2001, pp. 482-484
[Abstract] [Full Text]

News: INFECTIOUS DISEASES:
Malaria's Beginnings: On the Heels of Hoes?
Elizabeth Pennisi
Science, 20 Jul 2001, p. 416-417
[Summary] [Full Text]

In Silico Mapping of Complex Disease-Related Traits in Mice
A. Grupe et al.
Science, 8 June 2001, p. 1915-1918
[Abstract] [Full Text]

News: GENETICS:
Faster Maps Mean Fewer Mice
R. John Davenport
Science, 8 June 2001, p. 1814-1815
[Summary] [Full Text]

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKB)
Han Cho et al.
Science, 1 June 2001, p. 1728-1731
[Abstract] [Full Text]

Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein
C. K. Garcia et al.
Science, 18 May 2001, p. 1394-1396
[Abstract] [Full Text]

Perspective: MOLECULAR MEDICINE:
The Cholesterol Quartet
J. L. Goldstein and M. S. Brown
Science, 18 May 2001, p. 1310-1311
[Summary] [Full Text]

Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity
F. C. Nucifora Jr. et al.
Science, 23 March 2001, p. 2423-2429
[Abstract] [Full Text]

Future Directions: Dissecting Human Disease in the Postgenomic Era
Leena Peltonen and Victor A. McKusick
Science, 16 February 2001, p. 1224-1229
[Summary] [Full Text]

An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
K. L. Toh et al.
Science, 9 February 2001, p. 1040-1043
[Abstract] [Full Text]

Transmembrane Molecular Pump Activity of Niemann-Pick C1 Protein
J. P. Davies, F. W. Chen, and Y. A. Ioannou
Science, 22 December 2000, p. 2295-2298
[Abstract] [Full Text]

Identification of HE1 as the Second Gene of Niemann-Pick C Disease
S. Naureckiene et al.
Science, 22 December 2000, p. 2298-2302
[Abstract] [Full Text]

News: CELL BIOLOGY:
Disease Genes Clarify Cholesterol Trafficking
Science, 22 December 2000, p. 2227-2229
[Summary] [Full Text]

Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
L. Bertram et al.
Science, 22 December 2000, p. 2302
[Abstract] [Full Text]

Linkage of Plasma A-beta42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
N. Ertekin-Taner et al.
Science, 22 December 2000, p. 2303
[Abstract] [Full Text]

Susceptibility locus for Alzheimer's disease on Chromosome 10
A. Myers et al.
Science, 22 December 2000, p. 2304
[Abstract] [Full Text]

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters
Knut E. Berge et al.
Science, 1 December 2000, p. 1771-1775
[Abstract] [Full Text]

Perspective: BIOCHEMISTRY:
An Absorbing Study of Cholesterol
Hooman Allayee, Bryan A. Laffitte, and Aldons J. Lusis
Science, 1 December 2000, p. 1709-1711
[Summary] [Full Text]

Proximity of Chromosomal Loci That Participate in Radiation-Induced Rearrangements in Human Cells
Marina N. Nikiforova et al.
Science, 6 October 2000, p. 138-141
[Abstract] [Full Text]

Perspective: CANCER:
Proximity Matters
John R. K. Savage
Science, 6 October 2000, p. 62-63
[Summary] [Full Text]

PAX8-PPAR1 Fusion in Oncogene Human Thyroid Carcinoma
Todd G. Kroll et al.
Science, 25 August 2000, p. 1357-1360
[Abstract] [Full Text]

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22
Linda M. Brzustowicz, Kathleen A. Hodgkinson, Eva W. C. Chow, William G. Honer, and Anne S. Bassett
Science, 28 April 2000, p. 678-682
[Abstract] [Full Text]

Mutations in SDHD, a Mitochondrial Complex II Gene, in Hereditary Paraganglioma
Bora E. Baysal et al.
Science, 4 February 2000, p. 848-851
[Abstract] [Full Text]

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
Daphne W. Bell et al.
Science, 24 December 1999, p. 2528-2531
[Abstract] [Full Text]

News: HUMAN GENETICS:
Checkpoint Gene Linked to Human Cancer
Michael Hagmann
Science, 24 December 1999, p. 2433-2434
[Summary] [Full Text]

An Essential Role for BLNK in Human B Cell Development
Yoshiyuki Minegishi et al.
Science, 3 December 1999, p. 1954-1957
[Abstract] [Full Text]

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis
Susan E. Stepp et al.
Science, 3 December 1999, p. 1957-1959
[Abstract] [Full Text]

Altered Cochlear Fibrocytes in a Mouse Model of DFN3 Nonsyndromic Deafness
O. Minowa et al.
Science, 27 August 1999, p. 1408-1411
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
The Benefits of Recycling
Karen P. Steel
Science, 27 August 1999, p. 1363-1364
[Summary] [Full Text]

An Allele of COL9A2 Associated with Intervertebral Disc Disease
Susanna Annunen et al.
Science, 16 July 1999, p. 409-412
[Abstract] [Full Text]

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum
Robert E. Johnson, Christine M. Kondratick, Satya Prakash, and Louise Prakash
Science, 9 July 1999, p. 263-265
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Stopping DNA Replication in Its Tracks
James E. Cleaver
Science, 9 July 1999, p. 212-213
[Summary] [Full Text]

Review: Mitochondrial Diseases in Man and Mouse
Douglas C. Wallace
Science, 5 March 1999, p. 1482-1488
[Abstract] [Full Text]

A Molecular Pathway Revealing a Genetic Basis for Human Cardiac and Craniofacial Defects
Hiroyuki Yamagishi, Vidu Garg, Rumiko Matsuoka, Tiffani Thomas, and Deepak Srivastava
Science, 19 February 1999, p. 1158-1161
[Abstract] [Full Text]

News: HUMAN GENETICS:
A Gene That Scrambles Your Heart
Michael Hagmann
Science, 19 February 1999, p. 1091-1093
[Summary] [Full Text]

Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder
Ichizo Nishino, Antonella Spinazzola, and Michio Hirano
Science, 29 January 1999, p. 689-692
[Abstract] [Full Text]

Genetic Classification of Primary Neurodegenerative Disease
John Hardy and Katrina Gwinn-Hardy
Science, 6 November 1998, pp. 1075-1079
[Abstract] [Full Text]

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer
Steven Siqing Wang, Edward D. Esplin, Jia Ling Li, Liying Huang, Adi Gazdar, John Minna, and Glen A. Evans
Science, 9 October 1998, pp. 284-287
[Abstract] [Full Text]

Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration
Xiaolin Wu, Yuan Li, Bruce Crise, and Shawn M. Burgess
Science, 13 June 2003, p. 1749-1751
[Abstract] [Full Text]

Perspective: VIROLOGY:
Picking the Right Spot
Didier Trono
Science, 13 June 2003, p. 1670-1671
[Summary] [Full Text]

Subthalamic GAD Gene Therapy in a Parkinson's Disease Rat Model
Jia Luo et al.
Science, 11 October 2002, p. 425-429
[Abstract] [Full Text]

Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning
A. Aiuti, S. Slavin, M. Aker, F. Ficara, S. Deola, A. Mortellaro, S. Morecki, G. Andolfi, A. Tabucchi, F. Carlucci, E. Marinello, F. Cattaneo, S. Vai, P. Servida, R. Miniero, M.G. Roncarolo, C. Bordignon
Science, 28 June 2002, p. 2410-2413
[Abstract] [Full Text]

Tumor Regression by Targeted Gene Delivery to the Neovasculature
M. Bednarski, R. Frausto, S. Guccione, R.A. Reisfeld, R. Xiang, D.A. Cheresh
Science, 28 June 2002, p. 2404-2407
[Abstract] [Full Text]

News: CANCER RESEARCH:
Nanoparticles Cut Tumors' Supply Lines
Jennifer Cauzin
Science, 28 June 2002, p. 2314-2315
[Summary] [Full Text]

Murine Leukemia Induced by Retroviral Gene Marking
Zhixiong Li et al.
Science, 19 April 2002, p. 497
[Full Text]

Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy
Robert Pawliuk et al.
Science, 14 December 2001, p. 2368-2371
[Abstract] [Full Text]

News: GENE THERAPY:
Gene Gemisch Cures Sickle Cell in Mice
Eliot Marshall
Science, 14 December 2001, p. 2268
[Summary] [Full Text]

Perspective: DRUG DELIVERY:
Drugs on Target
R. Langer
Science, 6 July 2001, p. 58-59
[Summary] [Full Text]

Glucose-Dependent Insulin Release from Genetically Engineered K Cells
Anthony T. Cheung et al.
Science, 8 December 2000, p. 1959-1962
[Abstract] [Full Text]

Perspective: GENOMICS AND GENE THERAPY:
Artificial Chromosomes Coming to Life
Huntington F. Willard
Science, 17 November 2000, p. 1308-1309
[Summary] [Full Text]

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease
Jeffrey H. Kordower et al.
Science, 27 October 2000, p. 767-773
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Combating Parkinson's Disease--Step Three
Lars Olson
Science, 27 October 2000, p. 721-724
[Summary] [Full Text]

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease
Marina Cavazzana-Calvo et al.
Science, 28 April 2000, p. 669-672
[Abstract] [Full Text]

Perspective: GENE THERAPY:
The Best of Times, the Worst of Times
W. French Anderson
Science, 28 April 2000, p. 627-629
[Summary] [Full Text]

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery
Karl Lenhard Rudolph, Sandy Chang, Melissa Millard, Nicole Schreiber-Agus, and Ronald A. DePinho
Science, 18 February 2000, p. 1253-1258
[Abstract] [Full Text]

Prevention of Acute Liver Failure in Rats with Reversibly Immortalized Human Hepatocytes
Naoya Kobayashi et al.
Science, 18 February 2000, p. 1258-1262
[Abstract] [Full Text]

News: BIOMEDICINE:
New Genetic Tricks to Rejuvenate Ailing Livers
Michael Hagmann
Science, 18 February 2000, p. 1185-1187
[Summary] [Full Text]

Review: Prospects for in Utero Human Gene Therapy
Esmail D. Zanjani and W. French Anderson
Science, 24 September 1999, p. 2084-2088
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
Lentiviral Vectors--the Promise of Gene Therapy Within Reach?
Rafael G. Amado and Irvin S. Y. Chen
Science, 30 July 1999, p. 674-676
[Summary] [Full Text]

Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer
Xuehai Ye et al.
Science, 1 January 1999, p. 88-91
[Abstract] [Full Text]

Reovirus Therapy of Tumors with Activated Ras Pathway
Matthew C. Coffey, James E. Strong, Peter A. Forsyth, and Patrick W. K. Lee
Science, 13 November 1998, pp. 1332-1334
[Abstract] [Full Text]

News: ONCOLOGY:
Training Viruses to Attack Cancers
Elizabeth Pennisi
Science, 13 November 1998, pp. 1244-1246
[Summary] [Full Text]

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk
Hengmi Cui et al.
Science, 14 March 2003, p. 1753-1755
[Abstract] [Full Text]

Perspective: CANCER:
Developing Molecular Biomarkers for Cancer
David F. Ransohoff
Science, 14 March 2003, p. 1679-1680
[Summary] [Full Text]

Tech.Sight: GENETICS:
Genetic Testing-- Present and Future
Hai Yan, Kenneth W. Kinzler, and Bert Vogelstein
Science, 15 September 2000, p. 1890-1892
[Summary] [Full Text]

Viewpoint: Predictive Genetic Testing: From Basic Research to Clinical Practice
Neil A. Holtzman, Patricia D. Murphy, Michael S. Watson, and Patricia A. Barr
Science, 24 October 1997, pp. 602-605
[Abstract] [Full Text]

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
R. R. Amara et al.
Science, 6 April 2001, p. 69-74
[Abstract] [Full Text]

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Dan H. Barouch et al.
Science, 20 October 2000, p. 486-492
[Abstract] [Full Text]

Perspective: AIDS:
Preventing AIDS But Not HIV-1 Infection with a DNA Vaccine
Xuefei Shen and Robert F. Siliciano
Science, 20 October 2000, p. 463-465
[Summary] [Full Text]

An Oral Vaccine Against NMDAR1 with Efficacy in Experimental Stroke and Epilepsy
Matthew J. During et al.
Science, 25 February 2000, p. 1453-1460
[Abstract] [Full Text]

News: NEUROSCIENCE:
New Stroke Treatment Strategy Explored
Laura Helmuth
Science, 25 February 2000, p. 1379-1381
[Summary] [Full Text]

Modification of Ocular Defects in Mouse Developmental Glaucoma Models by Tyrosinase
Richard T. Libby et al.
Science, 7 March 2003, p. 1578-1581
[Abstract] [Full Text]

Perspective: BIOMEDICINE:
A New Angle on Ocular Development
Wallace L. M. Alward
Science, 7 March 2003, p. 1527-1528
[Summary] [Full Text]

Policy Forum: MEDICINE:
What Are the Right Targets for Psychopharmacology?
Steven E. Hyman and Wayne S. Fenton
Science, 17 January 2003, p. 350-351
[Summary] [Full Text]

A Functional Screen for the Type III (Hrp) Secretome of the Plant Pathogen Pseudomonas syringae
David S. Guttman et al.
Science, 1 March 2002, p. 1722-1726
[Abstract] [Full Text]

Spider Silk Fibers Spun from Soluble Recombinant Silk Produced in Mammalian Cells
Anthoula Lazaris et al.
Science, 18 January 2002, p. 472-476
[Abstract] [Full Text]

News: MATERIALS SCIENCE:
Mammalian Cells Spin a Spidery New Yarn
Robert F. Service
Science, 18 January 2002, p. 419-421
[Summary] [Full Text]

Identification of a Gene Associated with Bt Resistance in Heliothis virescens
L.J Gahan, F. Gould, and D.G. Heckel
Science, 3 August 2001, p. 857-860
[Abstract] [Full Text]

Bt Toxin Resistance from Loss of a Putative Carbohydrate-Modifying Enzyme
J.S. Griffitts et al.
Science, 3 August 2001, p. 860-864
[Abstract] [Full Text]

News: ENTOMOLOGY:
First Light on Genetic Root of Bt Resistance Revealed
Erik Stokstad
Science, 3 August 2001, p. 778
[Abstract] [Full Text]

Trophic Conversion of an Obligate Photoautotrophic Organism Through Metabolic Engineering
L. A. Zaslavskaia et al.
Science, 15 June 2001, p. 2073-2075
[Abstract] [Full Text]

Perspective: BIOCHEMISTRY:
How to Make a Superior Cell
Gregory Stephanopoulos and Joanne Kelleher
Science, 15 June 2001, p. 2024-2025
[Summary] [Full Text]

The Genetic Legacy of Paleolithic Homo sapiens sapiens in Extant Europeans: A Y Chromosome Perspective
Ornella Semino et al.
Science, 10 November 2000, p. 1155-1159
[Abstract] [Full Text]

News: EVOLUTIONARY GENETICS:
Europeans Trace Ancestry to Paleolithic People
Ann Gibbons
Science, 10 November 2000, p. 1080-1081
[Summary] [Full Text]

Review: Harnessing the Power of the Genome in the Search for New Antibiotics
John Rosamond and Aileen Allsop
Science, 17 March 2000, p. 1973-1976
[Abstract] [Full Text]

Review: Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
William E. Evans and Mary V. Relling
Science, 15 October 1999, p. 487-491
[Abstract] [Full Text]

Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray
M. A. Behr et al.
Science, 28 May 1999, p. 1520-1523
[Abstract] [Full Text]

Perspective: MICROBIOLOGY:
TB Vaccines: Global Solutions for Global Problems
Douglas B. Young and Brian D. Robertson
Science, 28 May 1999, p. 1479-1480
[Summary] [Full Text]

A Molecular Phylogeny of Reptiles
S. Blair Hedges and Laura L. Poling
Science, 12 February 1999, p. 998-1001
[Abstract] [Full Text]

Perspective: EVOLUTION:
Turtle Origins
Olivier Rieppel
Science, 12 February 1999, p. 945-946
[Summary] [Full Text]