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Science Functional Genomics
The Human Genome

Road to the Sequence

Here is a list of the news articles, reviews, papers, and perspective articles to which we've linked in our genome timeline.

First Steps Toward a Genetic Chemistry
Robert L. Sinsheimer
Science, 7 June 1957, v. 125 (3258): 1123-1128
[PDF] (520K)

RNA Codewords and Protein Synthesis
Marshall Nirenberg, Philip Leder
Science, 25 September 1964, v. 145 (3639): 1399-1407
[PDF] (850K)

Structure of a Ribonucleic Acid
Robert W. Holley et al.
Science, 19 March 1965, v. 147 (3664): 1462-1465
[PDF] (351K)

1968 Nobel Laureate in Medicine or Physiology
Maxine F. Singer
Science, 25 October 1968, v. 162 (3852): 433-436
[PDF] (665K)

Restriction Enzymes: New Tools for Studying DNA
Jean L. Marx
Science, 4 May 1973, v. 180 (4085): 482-485
[PDF] (448K)

Asilomar Conference on Recombinant DNA Molecules
Paul Berg, David Baltimore, Syndey Brenner, Richard O. Roblin III, Maxine F. Singer
Science, 6 June 1975, v. 188 (4192): 991-994
[PDF] (426K)

Molecular Cloning: Powerful Tool for Studying Genes
Jean L. Marx
Science, 19 March 1976, v. 191 (4232): 1160-1162
[PDF] (354K)

DNA Sequencing: A New Era in Molecular Biology
Gina Bari Kolata
Science, 14 May 1976, v. 192 (4240): 645-647
[PDF] (334K)

The Genome of Simian Virus 40
V. B. Reddy et al.
Science, 5 May 1978, v. 200 (4341): 494-502
[PDF] (972K)

Jumping Genes Help Trace Inherited Diseases
Roger Lewin
Science, 13 February 1981 v. 211 (4483): 690-692
[PDF] (358K)

Steps Toward Computer Analysis of Nucleotide Sequences
Thomas R. Gingeras, Richard J. Roberts
Science, 19 September 1980, v. 209 (4463): 1322-1328
[PDF] (990K)

Long-Awaited Decision on DNA Database
Roger Lewin
Science, 27 August 1982, v. 217(4562): 817-818
[PDF] (235K)

Enzymatic Amplification of b-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
Randall K. Saiki, Stephen Scharf, Fred Faloona, Kary B. Mullis, Glenn T. Horn, Henry A. Erlich, Norman Arnheim
Science, 20 December 1985, v. 230 (4732): 1350-1354
[PDF] (682K)

Direct Cloning and Sequence Analysis of Enzymatically Amplified Genomic Sequences
Stephen J. Scharf, Glenn T. Horn, Henry A. Erlich
Science, 5 September 1986, v. 233 (4768): 1076-1078
[PDF] (413K)

Multiplying Genes by Leaps and Bounds
Jean L. Marx
Science, 10 June 1988, v. 240 (4858): 1408-1410
[PDF] (450K)

A Turning Point in Cancer Research: Sequencing the Human Genome
Renato Dulbecco
Science, 7 March 1986, v. 231 (4742): 1055-1056
[PDF] (380K)

Proposal to Sequence Human Genome Stirs Debate
Roger Lewin
Science, 27 June 1986, v. 232 (4758): 1598-1600
[PDF] (375K)

Molecular Biology of Homo Sapiens
Roger Lewin
Science, 11 July 1986, v. 233 (4760): 157-160
[PDF] (1057K)

Shifting Sentiments over Sequencing the Human Genome
Roger Lewin
Science, 8 August 1986, v. 233 (4764): 620-621
[PDF] (303K)

Who Owns the Human Genome?
Leslie Roberts
Science, 24 July 1987, v. 237 (4813): 358-361
[PDF] (490K)

Agencies Vie over Human Genome Project
Leslie Roberts
Science, 31 July 1987, v. 237 (4814): 486-488
[PDF] (357K)

Cloning of Large Segments of Exogenous DNA into Yeast by means of Artificial Chromosome Vectors
David T. Burke, Georges F. Carle, Maynard V. Olson
Science, 15 May 1987, v. 236 (4803): 806-812
[PDF] (1350K)

Academy Backs Genome Project
Leslie Roberts
Science, 12 February 1988, v. 239 (4841): 725-726
[PDF] (558K)

Genome Project under Way, at Last
Leslie Roberts
Science, 13 January 1989, v. 243 (4888): 167-168
[PDF] (540K)

Genome Mapping Goal Now in Reach
Leslie Roberts
Science, 28 April 1989, v. 244 (4903): 424-425
[PDF] (266K)

A Common Language for Physical Mapping of the Human Genome
M. Olson, L. Hood, C. Cantor, D. Botstein
Science, 29 September 1989, v. 245 (4925): 1434-1435
[PDF] (236K)

The Human Genome Project: Past, Present, and Future
James D. Watson
Science, 6 April 1990 v. 248 (4951): 44-49
[PDF] (986K)

Orchestrating the Human Genome Project
Charles R. Cantor
Science, 6 April 1990, v. 248 (4951): 49-51
[PDF] (371K)

Mapping the Human Genome: Current Status
J. Claiborne Stephens, Mark L. Cavanaugh, Margaret I. Gradie, Martin L. Mador, Kenneth K. Kidd
Science, 12 October 1990, v. 250 (4978): 237-244
[PDF]

Radiation Hybrid Mapping: A Somatic Cell Genetic Method for Constructing High-Resolution Maps of Mammalian Chromosomes
David R. Cox, Margit Burmeister, E. Roydon Price, Suwon Kim, Richard M. Myers
Science, 12 October 1990, v. 250 (4978): 246-250
[PDF]

Gambling on a Shortcut to Genome Sequencing
Leslie Roberts
Science, 21 June 1991, v. 252 (5013): 1618-1619
[PDF] (178K)

Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project
Mark D. Adams et al.
Science, 21 June 1991, v. 252 (5013): 1651-1656
[PDF] (759K)

Genome Patent Fight Erupts
Leslie Roberts
Science, 11 October 1991, v. 254 (5029): 184-186
[PDF] (357K)

Why Watson Quit as Project Head
Leslie Roberts
Science, 17 April 1992, v. 256 (5055): 301-302
[PDF] (294K)

The Human Genome Initiative-Do Databases Reflect Current Progress?
P. L. Pearson, B. Maidak, M. Chipperfield, R. Robbins
Science, 11 October 1991, v. 254 (5029): 214-215
[PDF]

Hidden Messages in Genetic Maps
Christine J. Farr and Peter N. Goodfellow
Science, 2 October 1992, v. 258 (5079): 49
[PDF]

The Human Y Chromosome: A 43-Interval Map Based on Naturally Occurring Deletions
Douglas Vollrath, Simon Foote, Adrienne Hilton, Laura G. Brown, Peggy Beer-Romero, Jonathan S. Brogan, David C. Page
Science, 2 October 1992, v. 258 (5079): 52-59

The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region
Simon Foote, Douglas Vollrath, Adrienne Hilton, David C. Page
Science, 2 October 1992, v. 258 (5079): 60-66
[PDF]

A Comprehensive Genetic Linkage Map of the Human Genome
NIH/CEPH Collaborative Mapping Group
Science, 2 October 1992, v. 258 (5079): 67-86
[PDF]

Genome Analysis and the Human X Chromosome
Jean-Louis Mandel, Anthony P. Monaco, David J. Jelson, David Schlessinger, Huntington Willard
Science, 2 October 1992, v. 258 (5079): 103-109
[PDF]

Taking Stock of the Genome Project
Leslie Roberts
Science, 1 October 1993, v. 262 (5130): 20-22
[PDF] (443K)

A New Five-Year Plan for the U.S. Human Genome Project
Francis Collins and David Galas
Science, 1 October 1993, v. 262 (5130): 43-46
[PDF]

Managing All Those Bytes: The Human Genome Project
A. Jamie Cuticchia, Michael A. Chipperfield, Christopher J. Porter, William Kearns, Peter L. Pearson
Science, 1 October 1993, v. 262 (5130): 47-48
[PDF]

Assessing Mapping Progress in the Human Genome Project
David R. Cox, Eric D. Green, Eric S. Lander, Daniel Cohen, Richard M. Meyers
Science, 30 September 1994, v. 265 (5181): 2031-2032
[PDF]

A Database for Mouse Development
Martin Ringwald, Richard Baldock, Jonathan Bard, Matthew Kaufman, Janan T. Eppig, Joel E. Richardson, Joseph H. Nadeau, Duncan Davidson
Science, 30 September 1994, v. 265 (5181): 2033-2034
[PDF]

The Human Genome Project: Under an International Ethical Microscope
Bartha Maria Knoppers and Ruth Chadwick
Science, 30 September 1994, v. 265 (5181): 2035-2036
[PDF]

Genetic Dissection of Complex Traits
Eric S. Lander and Nicholas J. Schork
Science, 30 September 1994, v. 265 (5181): 2037-2048
[PDF]

A Comprehensive Human Linkage Map with Centimorgan Density
Cooperative Human Linkage Center (CHLC): Jeffrey C. Murray, Kenneth H. Buetow, James L. Weber, Susan Ludwigsen, Titia Scherpbier-Heddema, Frank Manion, John Quillen, Val C. Sheffield, Sara Sunden, Geoffrey M. Duyk; Genethon: G. Mark Lathrop, Alain Vignal; University of Utah: Ray White, Norisada Matsunami, Steven Gerken, Roberta Melis, Hans Albertsen, Rosmarie Plaetke, Shannon Odelberg; Yale University: David Ward; Centre d'Etude du Polymorphisme Humain (CEPH): Jean Dausset, Daniel Cohen, Howard Cann
Science, 30 September 1994, v. 265 (5181): 2049-2054
[PDF]

Whole-Genome Random Sequencing and Assembly of Haemophilus Influenzae Rd
Robert D. Fleischmann et al.
Science, 28 July 1995, v. 269 (5223): 496-512
Article, excluding Fig. 1 and Table 1: [PDF] (2165K)
Fig. 1 and Table 1 of article: [PDF] (2102K)

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Mark Schena, Dari Shalon, Ronald W. Davis, and Patrick O. Brown
Science, 20 October 1995, v. 270 (5235): 467-470
[PDF] (1142K)

The Minimal Gene Complement of Mycoplasma genitalium
C. M. Fraser et al.
Science, 20 October 1995, v. 270 (5235): 397-404
[PDF]

Transfer of Genes to Humans: Early Lessons and Obstacles to Success
Ronald G. Crystal
Science, 20 October 1995, v. 270 (5235): 404-409
[PDF]

A New Guide to the Human Genome
Jean Marx
Science, 22 December 1995, v. 270 (5244): 1919-1920
[PDF] (193K)

An STS-Based Map of the Human Genome
Thomas J. Hudson et al.
Science, 22 December 1995, v. 270 (5244): 1945-1954
[PDF] (1472K)

A Gene Map of the Human Genome
G. D. Schuler et al.
Science, 25 October 1996, v.274 (5287)
[Abstract] [Full text]

Life with 6000 Genes
A. Goffeau et al.
Science, 25 October 1996, v. 274 (5287)
[Abstract] [Full text]

Accessing Genetic Information with High-Density DNA Arrays
Mark Chee et al.
Science, 25 October 1996, v. 274 (5287)
[Abstract] [Full text]

Genomic Sequence Information Should Be Released Immediately and Freely in the Public Domain
David R. Bentley
Science, 25 October 1996, v. 274 (5287)
[Summary] [Full text]

Should Non-Peer-Reviewed Raw DNA Sequence Data Release Be Forced on the Scientific Community?
Mark D. Adams and J. Craig Venter
Science, 25 October 1996, v. 274 (5287)
[Summary] [Full text]

The New Genomics: Global Views of Biology
Eric S. Lander
Science, 25 October 1996, v. 274 (5287)
[summary] [Full text]

The Complete Genome Sequence of Escherichia coli K-12
F. R. Blattner et al.
Science, 5 September 1997, v. 277 (5331)
[Abstract] [Full text]

Sequencing the Human Genome
Lee Rowen, Gregory Mahairas, and Leroy Hood
Science, 24 October 1997, v. 278 (5338)
[Abstract] [Full text]

DNA Sequencers' Trial by Fire
Elizabeth Pennisi
8 May 1998, v. 280 (5365)
[Summary] [Full text]

Playing With the Numbers
Elizabeth Pennisi
8 May 1998, v. 280 (5365)
[Summary] [Full text]

The Key to Success Is Finishing Well
Elizabeth Pennisi
8 May 1998, v. 280 (5365)
[Summary] [Full text]

Hubris and the Human Genome
Eliot Marshall
15 May 1998, v. 280 (5366)
[Summary] [Full text]

Shotgun Sequencing of the Human Genome
J. C. Venter, M. D. Adams, G. G. Sutton, A. R. Kerlavage, H. O. Smith, M. Hunkapiller
5 June 1998, v. 280 (5369): 1540-1542
[Summary] [Full text]

NIH to Produce a 'Working Draft' of the Genome by 2001
Eliot Marshall
Science, 18 September 1998, v. 281 (5384): 1774-1775
[Summary] [Full Text]

Special Issue: C. elegans -- Sequence to Biology
Science, 11 December 1998, v. 282 (5396)

Academic Sequencers Challenge Celera in a Sprint to the Finish
Elizabeth Pennisi
Science, 19 March 1999, v. 283 (5409): 1822-1823
[Summary] [Full Text]

Sequencers Endorse Plan for a Draft in 1 Year
Eliot Marshall
Science, 28 May 1999, v. 284 (5419): 1439-1441
[Summary] [Full Text]

A High-Stakes Gamble on Genome Sequencing
Eliot Marshall
Science, 18 Jun 1999, v. 284 (5422): 1906-1909
[Summary] [Full Text]

Special Issue: The Drosophila Genome
Science, 24 March 2000, v. 287 (5461)

Talks of Public-Private Deal End in Acrimony
Eliot Marshall
Science, 10 March 2000, v. 287 (5459): 1723-1725
[Summary] [Full Text]

Clinton and Blair Back Rapid Release of Data
Eliot Marshall
Science, 17 March 2000, v. 287 (5460): 1903
[Summary] [Full Text]

How a Bland Statement Sent Stocks Sprawling
Eliot Marshall
Science, 24 March 2000: 2127
[Summary] [Full Text]

Science Interview: In the Crossfire: Collins on Genomes, Patents, and "Rivalry"
Eliot Marshall, Elizabeth Pennisi, and Leslie Roberts
Science, 31 March 2000, v. 287 (5462): 2396-2398
[Summary] [Full Text]

Rival Genome Sequencers Celebrate a Milestone Together
Eliot Marshall
Science, 30 June 2000, v. 288 (5475): 2294-2295
[Summary] [Full Text]

Finally, the Book of Life and Instructions for Navigating It
Elizabeth Pennisi
Science, 30 June 2000, v. 288 (5475): 2304-2307
[Summary] [Full Text]

News Focus: Arabidopsis
Science, 15 December 2000, v. 290 (5499)
Plants join the genome sequencing bandwagon
Stalking the wild mustard
Arabidopsis kin help keep genetics studies all in the family
Centromeres: A journey to the center of the chromosome

Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
J. L. Riechmann et al.
Science 15 December 2000, v. 290 (5499): 2105-2110
[Abstract] [Full Text]

Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock
Stacey L. Harmer et al.
Science, 15 December 2000, v. 290 (5499): 2110-2113
[Abstract] [Full Text]

The Origins of Genomic Duplications in Arabidopsis
Todd J. Vision, Daniel G. Brown, and Steven D. Tanksley
Science, 15 December 2000, v. 290 (5499): 2114-2117
[Abstract] [Full Text]

Human genome: Storm erupts over terms for publishing Celera's sequence
Science, 15 December 2000, v. 290 (5499)
[Summary] [Full text]

Breakthrough of the Year: Genomes
Science, 22 December 2000, v. 290 (5500)
[Summary] [Full text]

Special Issue: The Human Genome
Science, 16 February 2001, v. 291 (5507)




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