Dendritic cells utilize avb5 and CD36 for the phagocytosis and cross-presentation of antigen derived from apoptotic cells. Dendritic cells (DCs) phagocytose apoptotic cells and cross-present antigens derived from the dying cells to stimulate virus- and tumor-specific CD8+ T cells. Phagocytosis is restricted to the immature stage of DCs and is accompanied by the expression of the avb5 integrin and CD36. Although macrophages (Mp) efficiently phagocytose apoptotic cells via many receptors, including avb3 and CD36, they do not cross-present antigens to CD8+ T cells.

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