Research Articles and Reports:

On Anopheles gambiae
On Plasmodium falciparum

News and Commentary:

Editorial
Special Issue Introduction
Opening Viewpoint
News Coverage
Viewpoints

Anopheles gambiae: Genome Sequence, Comparative Genomics, and Molecular Biology

The Genome Sequence of the Malaria Mosquito Anopheles gambiae
R. A. Holt et al.; Science 298, 129 (2002)
[Abstract] [Full Text]

Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
E. M. Zdobnov et al.; Science 298, 149 (2002)
[Abstract] [Full Text]

Immunity-Related Genes and Gene Families in Anopheles gambiae
G. K. Christophides et al.; Science 298, 159 (2002)
[Abstract] [Full Text]

Neuropeptides and Peptide Hormones in Anopheles gambiae
M. A. Riehle et al.; Science 298, 172 (2002)
[Abstract] [Full Text]

G Protein-Coupled Receptors in Anopheles gambiae
C. A. Hill et al.; Science 298, 176 (2002)
[Abstract] [Full Text]

Evolution of Supergene Families Associated with Insecticide Resistance
H. Ranson et al.; Science 298, 179 (2002)
[Abstract] [Full Text]

Inversions and Gene Order Shuffling in Anopheles gambiae and A. funestus
I. V. Sharakhov et al.; Science 298, 182 (2002)
[Abstract] [Full Text]

In Science Express:
A Polytene Chromosome Analysis of the Anopheles gambiae Species Complex
M. Coluzzi et al.; 10.1126/science.1077769 (2002)
[Abstract] [PDF]

Plasmodium falciparum: Genetics, Drug Resistance, and Parasite-Mosquito Interactions

Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations
A. B. S. Sidhu, D. Verdier-Pinard, D. A. Fidock; Science 298, 210 (2002)
[Abstract] [Full Text]

Perspective: A Requiem for Chloroquine
I. M. Hastings, P. G. Bray, S. A. Ward; Science 298, 74 (2002)
[Summary] [Full Text]

Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population
O. Niaré et al.; Science 298, 213 (2002)
[Abstract] [Full Text]

Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum
S. K. Volkman et al.; Science 298, 216 (2002)
[Abstract] [Full Text]

Poster and Web Extras Anopheles gambiae Poster We offer two online versions of the poster on the malaria mosquito, its genome, and its impact that was included with the 4 October 2002 print issue of Science: An interactive edition (on Science Functional Genomics Web site) with embedded links to online resources and special-issue articles related to the poster's themes. A PDF version (1.6 MB) that can be downloaded and printed out on an 11×17 sheet. The Malaria System: Online Resources on the Biology of Anopheles, Plasmodium, and Man A collection of Web resources, from the Science Functional Genomics Web site. Meet the Mosquitoes Quick looks at the lifestyles and disease influence of A. gambiae and nine of its cousins. From Science's News Department.

Editorial

The Anopheles gambiae Genome: Completing the Malaria Triad
K. S. Aultman, M. Gottlieb, M. Giovanni, A. S. Fauci; Science 298, 13 (2002)
[Full Text]

Special Issue Introduction

Taking a Genomic Bite of the Malaria Mosquito
B. R. Jasny, O. M. Smith, L. Roberts, M. Enserink; Science 298, 77 (2002)
[Full Text]

Opening Viewpoint

The Mosquito Genome -- A Breakthrough for Public Health
C. M. Morel, Y. T. Touré, B. Dobrokhotov, A. M. J. Oduola; Science 298, 79 (2002)
[Abstract] [Full Text]

News Coverage

On Anopheles:

Creatures of Our Own Making
S. Budiansky; Science 298, 80 (2002)
[Summary] [Full Text]

Meet the Mosquitoes
M. Enserink; Science 298 (2002)
[Full text]

Mosquitoes and Disease
Science 298, 82 (2002)
[Summary]

In Pursuit of a Killer
G. Vogel; Science 298, 87 (2002)
[Summary] [Full Text]

What Mosquitoes Want: Secrets of Host Attraction
M. Enserink; Science 298, 90 (2002)
[Summary] [Full Text]

Lab v. Field: The Case for Studying Real-Life Bugs
M. Enserink; Science 298, 92 (2002)
[Summary] [Full Text]

An Elegant But Imperfect Tool
G. Vogel; Science 298, 94 (2002)
[Summary] [Full Text]

On Plasmodium:

Parasite Genome Sequenced, Scrutinized
E. Pennisi; Science 298, 33 (2002)
[Summary] [Full Text]

Viewpoints

An Overview of Insecticide Resistance
J. Hemingway, L. Field, J. Vontas; Science 298, 96 (2002)
[Abstract] [Full Text]

The Anopheles Genome and Comparative Insect Genomics
T. C. Kaufman, D. W. Severson, G. E. Robinson; Science 298, 97 (2002)
[Abstract] [Full Text]

Speciation within Anopheles gambiae -- the Glass is Half Full
A. della Torre et al.; Science 298, 115 (2002)
[Abstract] [Full Text]

The Ecology of Genetically Modified Mosquitos
T. W. Scott, W. Takken, B. G. J. Knols, C. Boëte; Science 298, 117 (2002)
[Abstract] [Full Text]

Malaria Control with Genetically Manipulated Vectors
L. Alphey et al.; Science 298, 119 (2002)
[Abstract] [Full Text]

Malaria -- a Shadow over Africa
L. H. Miller and B. Greenwood; Science 298, 121 (2002)
[Abstract] [Full Text]

A New Global Effort to Control Malaria
J. D. Sachs; Science 298, 122 (2002)
[Abstract] [Full Text]

Plasmodium Chloroquine Resistance and the Search for a Replacement Antimalarial Drug
T. E. Wellems; Science 298, 124 (2002)
[Abstract] [Full Text]

The Plasmodium Falciparum Genome -- a Blueprint for Erythrocyte Invasion
A. F. Cowman and B. S. Crabb; Science 298, 126 (2002)
[Abstract] [Full Text]