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Mammalian Ion Channels With Proline-Rich PXXP Motifs

Sequences, designated by their GenBank/EMBL accession numbers, were retrieved from the NCBI Entrez database

Ion Channel (species, accession number) Proline-Rich Sequence(s)
Potassium Channels
Shaker-related subfamily
Kv1.2 (human, L02752) 16PGHPQDTYDP, 436PKIPSSP
Kv1.3 (rat, X16001) 35RYEPLPPALP
Kv1.3 (human, M55515) 43RYEPLPPSLP
Kv1.5 (rat, M27158) 65RPLPPMA
Kv1.5 (human, M55513) 65RPLPPLPDPGVRPLPPLPEELPRRP
Kv1.6 (human, X17622) 149KPLPSQP

Shab-related subfamily
Kv2.1 (rat, X16476) 13PPEPMEIV, 562PSPVAPLP, 576PTPLLP, 596PLPTSPKFRP
Kv2.2 (rat, M77482) 21PPEPVEII, 619PLTPVP

Shaw-related subfamily
Kv3.1 (rat, M68880) 461PRPPQLGSP
Kv3.2 (rat, M34052) 56PLPPPLSPPPRPPPLSPVP, 498PPAPLASSP, 550PPLSPPERLP
Kv3.3 (rat, M84210-1) 33PAPTPQPPESSPPPLLPP, 565PRPPQPGSPNYCKPDPPPPPPPHP, 597PPPPITPP, 615PPGPHTHP, 638PPLPAPGEPCP
Kv3.4 (human, M64676) 551PQWPREFPNGP

Shal-related subfamily
Kv4.1 (mouse, M64226) 25QPLPPAP, 606PTPPANTPDESQPSSP
Kv4.2 (rat, S64320) 21PAVSPMPAPP
Kv4.3 (rat, L48619) 21PVANCPMPLAP

Small K(Ca) channel subfamily
hSK1 (human, U69883) 69PARPSPGSPRGQP, 526RPPPPPLPPRPGPGP

NMDA Receptor/Channels
NMDA2C (mouse, Q01098) 942PGPPGQPSPSGWRPP, 962PLARRAPQPPARPQP
NMDA2D (rat, L31612) 900PPPAKPPPPPQPLPRPPPGPAP, 926PLSPPTTQPPQKPPPPGFPSPPAPP

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Science. ISSN 0036-8075 (print), 1095-9203 (online)