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Special Web Supplement

Biological Imaging:  Some Web Resources

4 April 2003 cover The 4 April 2003 special issue of Science highlights recent advances in microscopy, fluorescent protein technology, and image analysis that have revolutionized how we view and understand the dynamic structures and events that embody living cells. To complement the Review, Viewpoint, and News articles in the special issue, we've compiled a list of Web resources and past Science articles that delve deeper into topics in bioimaging and microscopy.

Also: Be sure to check out our online bioimaging slide show.

General Resources

Molecular Expressions
A comprehensive resource maintained by Florida State University. Includes a Microscopy Primer with tutorials on optical microscopy, digital imaging, and photomicrography; a list of microscopy web resources; and several image galleries.
microscopy.info
An information source for microscopy and microanalysis including a hyperlinked glossary and links to professional societies and educational resources.
World Wide Web Virtual Library: Microscopy
Vast set of links covering all aspects of light, electron, and other types of microscopy, including extensive lists of imaging and microscopy labs, image galleries, and educational sites.
Live Cell Imaging Applications in Confocal Microscopy
A lecture by Dr. J. Paul Robinson at Purdue University.
NIH Office of Extramural Research: Links to Bioimaging Sites
Includes a list of journals and societies devoted to topics in bioimaging.
Standard Microscopy Terminology
A comprehensive glossary of microscopy terms made available by the University of Minnesota Characterization Facility.
Microscopy and Imaging Resources on the WWW
A very well-organized, extensive collection of educational and informational resources, including links to numerous online image galleries, microscopy sites, and an introduction to digital imaging. Made available by the University of Arizona Cellular Imaging Core.

Imaging Centers

Caltech Biological Imaging Center
Develops new technologies and provides facilities for imaging biological structure and function using calcium imaging and video, confocal, two-photon, and magnetic resonance microscopy.
Center for In Vivo Microscopy
An NIH National Center for Research Resources (NCRR) at Duke University Medical Center that develops the technology of magnetic resonance microscopy and applies it to basic and applied science.
National Center for Microscopy and Imaging Research
A unit of the UCLA School of Medicine dedicated to using state-of-the-art imaging technology to develop molecular imaging assays for studying biological systems.
Crump Institute for Molecular Imaging
A federally funded research facility specializing in the development of technologies for improving the understanding of biological structure and function relationships.
Beckman Institute Imaging Technology Group
Provides advanced imaging technologies through two core facilities: the Microscopy Suite and the Visualization, Media and Imaging Laboratory (VMIL) with extensive computing facilities for data analysis, processing, and interpretation.

Image-Sharing Databases/Projects

BioImage
Funded by the European Union, the BioImage Database Project aims to provide the general scientific community with a flexible and searchable database of multi-dimensional biological images.
Biomedical Informatics Research Network (BIRN)
An NCRR and a network for scientists to distribute and share brain imaging data, including high-resolution digital magnetic resonance images (MRI) of brain structure and function, advanced 3-D microscope images, and related genomic, structural, and gene expression data.
Open Microscopy Environment (OME)
Object-oriented, database-driven software system for quantitative analysis of biological images.
The Whole Brain Atlas
A collection of over 13,000 MRI, tomographic, and nuclear medicine images of normal brains and brains damaged by major central nervous system diseases.

Selected Science Articles

Beautiful Bioimages for the Eyes of Many Beholders
News Focus article (5 July 2002), by V. Marx, on the emergence of image-sharing databases and software systems aimed at making image collections accessible to all scientists.
Optical Sectioning -- Slices of Life
Tech.Sight article (15 February 2002), by S. Paddock, describes recent advances in confocal microscopy.
Cell Migration Research Is on the Move
News Focus article (25 January 2002), by M. Chicurel, highlights new techniques that allow researchers to follow the dynamics of cellular movement.
Color by Number: Imaging Large Data
Tech.Sight article (17 August 2001), by C. Bertrand, discusses the technical and practical aspects of using images for conveying information.
Neuroimaging Databases
Viewpoint article (1 June 2001) written by the Governing Council of the Organization for Human Brain Mapping (OHBP) to identify and frame issues concerning data sharing within the neuroimaging community.
New Imaging Tools Put the Art Back Into Science
News article (11 May 2001), by A. Lawler, discusses how use of new imaging technologies is raising questions about the role of aesthetics in science and the fine line between enhancement and falsification.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)