| Supplemental Table 1. Comparative analysis of selected human disease genes against D. melanogaster (F), C. elegans (W), and S. cerevisiae (Y). OMIM numbers and GenBank identifiers for each of the disease genes included in the analysis. The BLAST e-value columns have the e-value for the top BLAST match. The database identifiers are the top BLAST match for worm and yeast matches, and the most likely ortholog for the fly matches. The identifiers represent the protein ids from the original sequencing center. These identifiers can be searched at CeleraScience. |
| |
|
|
|
BLAST e-values |
|
|
Database Identifiers |
|
| Cancer |
OMIM Number |
Genbank Identifier for the human sequence |
F |
W |
Y |
F |
W |
Y |
| ABL1 |
189980 |
28237 |
0.00E+00 |
1.00E-162 |
4.00E-21 |
CT13380 |
M79.1B |
YMR001C |
| Acute Myeloid Leukemia-DEK |
125264 |
4503249 |
1.00E-17 |
1.30E+00 |
1.90E+00 |
CT18411 |
|
|
| Adenomat. Polyposis Coli-APC |
175100 |
182397 |
1.00E-135 |
6.00E-34 |
6.00E-05 |
CT3529 |
K04G2.9 |
|
| AKT2 |
164731 |
178326 |
1.00E-179 |
1.00E-162 |
3.00E-85 |
CT38917 |
C12D8.11 |
YKL127W |
| Ataxia Telangiectasia-ATM |
208900 |
2304971 |
1.00E-145 |
2.00E-49 |
4.00E-92 |
CT20331 |
B0261.2 |
YBL088C |
| BRCA1 |
113705 |
555932 |
2.00E-06 |
9.00E-11 |
5.00E-05 |
|
C36A4.8 |
|
| BRCA2 |
600185 |
1161384 |
1.00E-03 |
2.00E+00 |
8.60E+00 |
|
|
|
| Basal Cell Nevus-PTC |
601309 |
1381236 |
1.00E-128 |
8.00E-95 |
9.00E-16 |
CT7996 |
ZK675.1 |
YPL006W |
| B-Cell Lymphoma 2-BCL2 |
151430 |
179371 |
6.00E-06 |
1.00E+00 |
5.80E+00 |
CT24465 |
|
|
| B-Cell Lymphoma 3-BCL3 |
109560 |
179376 |
2.00E-28 |
4.00E-23 |
3.00E-08 |
|
C04F12.3 |
YIL112W |
| Bloom-BLM |
210900 |
1072122 |
1.00E-148 |
1.00E-120 |
1.00E-109 |
CT21426 |
T04A11.6 |
YMR190C |
| Burkitt's Lymphoma-MYC |
190080 |
386965 |
2.00E-09 |
4.00E-07 |
1.70E-02 |
CT10490 |
F46G10.6 |
|
| CDKN2C |
600160 |
639716 |
5.00E-08 |
1.00E-08 |
6.00E-05 |
|
D2021.8 |
|
| CSF1R/C-Fms |
164770 |
29900 |
7.00E-70 |
2.00E-63 |
3.00E-16 |
|
F58A3.2 |
YJL095W |
| Chk2 Protein Kinase |
604373 |
6005850 |
8.00E-61 |
4.00E-58 |
2.00E-50 |
CT30511 |
Y60A3A |
YDL101C |
| PDGFB |
190040 |
338211 |
7.00E-10 |
5.00E-04 |
1.50E+00 |
|
|
|
| CML-BCR |
151410 |
29421 |
2.00E-99 |
2.00E-21 |
1.00E-16 |
CT40020 |
C38D4.5 |
YER155C |
| Cyclin D1-CCND1 |
168461 |
181245 |
6.00E-33 |
3.00E-20 |
4.00E-12 |
CT26100 |
Y38F1A.5 |
YGR108W |
| Cyclin Dep. Kinase 4-CDK4 |
123829 |
1353416 |
3.00E-72 |
2.00E-58 |
8.00E-55 |
CT16072 |
F18H3.5A |
YBR160W |
| EGFR |
131550 |
757924 |
1.00E-134 |
1.00E-81 |
6.00E-18 |
CT28361 |
ZK1067.1 |
YOL113W |
| ERBB2 |
164870 |
306840 |
1.00E-114 |
2.00E-64 |
3.00E-14 |
CT28361 |
ZK1067.1 |
YOL113W |
| ETS |
164720 |
182269 |
3.00E-32 |
2.00E-30 |
2.30E+00 |
|
C42D8.4 |
|
| E-Cadherin-CDH1 |
192090 |
31073 |
2.00E-32 |
2.00E-18 |
2.80E+00 |
|
R10F2.1 |
|
| Ewing Sarcoma-FLI-1 |
193067 |
32530 |
1.00E-59 |
6.00E-54 |
3.50E-01 |
CT21666 |
T08H4.3 |
|
| FGF3 |
164950 |
312409 |
2.00E-12 |
8.00E-16 |
7.40E+00 |
|
C05D11.4 |
|
| Fanconi's Anemia A-FANCA |
227650 |
4503655 |
2.60E+00 |
8.50E-01 |
8.20E-02 |
|
|
|
| Fanconi's Anemia C-FANCC |
227645 |
4557589 |
7.30E-01 |
5.40E-01 |
3.90E+00 |
|
|
|
| Fanconi's Anemia G-FANCG |
602956 |
3860408 |
5.40E+00 |
3.90E+00 |
4.30E+00 |
|
|
|
| HNPCC*-MSH2 |
120435 |
433147 |
0.00E+00 |
1.00E-113 |
0.00E+00 |
CT11513 |
H26D21.2 |
YOL090W |
| HNPCC*-MSH3 |
600887 |
1490521 |
4.00E-67 |
2.00E-64 |
1.00E-126 |
CT21676 |
Y47G6A.11 |
YCR092C |
| HNPCC*-MSH6 |
600678 |
1294813 |
0.00E+00 |
0.00E+00 |
1.00E-135 |
CT21676 |
Y47G6A.11 |
YDR097C |
| HNPCC*-MLH1 |
120436 |
466462 |
0.00E+00 |
1.00E-106 |
1.00E-138 |
CT36319 |
T28A8.7 |
YMR167W |
| HNPCC*-PMS2 |
600259 |
535515 |
0.00E+00 |
1.00E-124 |
1.00E-124 |
CT21953 |
H12C20.2A |
YNL082W |
| KIT |
164920 |
34085 |
6.00E-65 |
1.00E-61 |
4.00E-17 |
|
F58A3.2 |
YJL095W |
| LCK |
153390 |
187034 |
1.00E-143 |
1.00E-116 |
5.00E-21 |
|
F49B2.5 |
YAR019C |
| Lymphoma-MCF2 |
311030 |
30482 |
4.00E-46 |
4.00E-32 |
4.00E-06 |
CT29242 |
C14A11.3 |
|
| MADH4 |
600993 |
1163234 |
1.00E-101 |
2.00E-39 |
1.50E-01 |
CT5334 |
R12B2.1 |
|
| MDM2 |
164785 |
266516 |
2.00E-03 |
1.00E-06 |
9.00E-03 |
|
F10D7.5 |
|
| MET |
164860 |
307196 |
6.00E-53 |
1.00E-68 |
9.00E-22 |
|
F11E6.8 |
YAR019C |
| MEN1 |
131100 |
6166545 |
1.00E-99 |
5.90E-01 |
1.00E+00 |
CT33266 |
|
|
| MEN2A-RET |
171400 |
547807 |
1.00E-111 |
2.00E-71 |
7.00E-20 |
CT1245 |
F58A3.2 |
YAR019C |
| Multiple Exostosis 1-EXT1 |
133700 |
1168162 |
0.00E+00 |
7.00E-74 |
1.00E+00 |
CT28467 |
F12F6.3 |
|
| Multiple Exostosis 2-EXT2 |
133701 |
3023739 |
0.00E+00 |
1.00E-60 |
1.00E-02 |
CT18005 |
K01G5.6 |
|
| NTRK1 |
191315 |
339918 |
5.00E-74 |
4.00E-55 |
4.00E-20 |
|
C01G6.8 |
YDR122W |
| Neurofibromatosis 1-NF1 |
162200 |
292354 |
0.00E+00 |
1.00E-22 |
1.00E-64 |
CT24543 |
ZK899.8G |
YBR140C |
| Neurofibromatosis 2-NF2 |
101000 |
292292 |
1.00E-147 |
1.00E-123 |
3.00E-03 |
CT33843 |
C01G8.5A |
|
| Nijmegen Breakage 1-NBS1 |
602667 |
3126795 |
1.00E-34 |
1.00E-04 |
5.00E-07 |
CT20975 |
|
YDL058W |
| Nucleoporin-NUP214 |
114350 |
548384 |
7.00E-42 |
6.00E-23 |
2.00E-12 |
CT12729 |
C03D6.4 |
YIR019C |
| P16-INK4 |
600160 |
558657 |
2.00E-07 |
1.00E-05 |
1.00E-04 |
|
|
|
| P16-INK4A |
600160 |
4502749 |
2.00E-07 |
1.00E+05 |
1.00E-04 |
|
|
|
| P19 ARF |
600160 |
1000571 |
1.00E+00 |
1.00E+00 |
1.00E+00 |
|
|
|
| P53 |
191170 |
35214 |
2.00E-08 |
0.81 |
1 |
CT30451 |
|
|
| PTEN |
601728 |
2811005 |
3.00E-73 |
5.00E-47 |
8.00E-17 |
CT17882 |
T07A9.6 |
YNL128W |
| RAS |
190020 |
190891 |
2.00E-74 |
1.00E-72 |
7.00E-49 |
CT26623 |
ZK792.6 |
YOR101W |
| REL |
164910 |
402649 |
2.00E-68 |
1.50E-01 |
3.80E-01 |
CT20694 |
|
|
| Retinoblastoma-RB1 |
180200 |
190959 |
1.00E-35 |
5.00E-22 |
7.60E-01 |
CT22763 |
C32F10.2 |
|
| STK11 |
602216 |
2791676 |
1.00E-106 |
1.00E-34 |
8.00E-35 |
CT26569 |
W03G1.6 |
YDR477W |
| Stem Cell Leukemia-TAL1 |
187040 |
337970 |
5.00E-22 |
2.00E-09 |
1.00E+00 |
CT8939 |
T15H9.3 |
|
| Tuberous Sclerosis 1-TSC1 |
191100 |
2331281 |
2.00E-43 |
8.00E-08 |
4.00E-08 |
CT19312 |
F07A5.7 |
YDR356W |
| Tuberous Sclerosis 2-TSC2 |
191092 |
4071058 |
1.00E-144 |
2.00E-14 |
7.70E+00 |
CT21583 |
F47F6.7 |
|
| Von Hippel Lindau-VHL |
193300 |
2282064 |
1.00E-02 |
3.00E-03 |
3.80E+00 |
|
|
|
| Wilm's Tumor-WT1 |
194070 |
139778 |
4.00E-28 |
3.00E-28 |
9.00E-21 |
|
F56F11.3 |
YOR113W |
| Xeroderma Pigment. A-XPA |
278700 |
139816 |
2.00E-50 |
3.00E-39 |
1.00E-13 |
CT19848 |
K07G5.2 |
YMR201C |
| Xeroderma Pigment. B-ERCC3 |
133510 |
119541 |
0.00E+00 |
2.60E-01 |
0.00E+00 |
CT24084 |
|
YIL143C |
| Xeroderma Pigment. D-XPD |
278730 |
119540 |
0.00E+00 |
6.00E-52 |
0.00E+00 |
CT26722 |
F25H2.13 |
YER171W |
| Xeroderma Pigment. F-XPF |
278760 |
2842712 |
8.00E-93 |
1.00E-49 |
1.00E-60 |
CT12377 |
VF13D12L.2 |
YPL022W |
| Xeroderma Pigment. G-XPG |
278780 |
267420 |
1.00E-64 |
8.00E-23 |
6.00E-47 |
CT30499 |
F57B10.6 |
YGR258C |
| |
|
|
|
|
|
|
|
|
| Neurological |
|
|
|
|
|
|
|
|
| Adrenoleukodystrophy-ABCD1 |
300100 |
38591 |
0.00E+00 |
0.00E+00 |
7.00E-93 |
CT7456 |
T02D1.5 |
YPL147W |
| Alzheimer-PS1 |
104311 |
1709856 |
1.00E-96 |
5.00E-85 |
3.20E+00 |
CT18359 |
F35H12.3 |
|
| Alzheimer-APP |
104760 |
2429081 |
3.00E-22 |
2.00E-36 |
1.00E-04 |
CT23451 |
C42D8.8 |
|
| Amyotrophic Lat. Sclero.-SOD1 |
147450 |
338276 |
9.00E-51 |
1.00E-46 |
2.00E-44 |
CT36899 |
C15F1.7 |
YJR104C |
| Angelman-UBE3A |
601623 |
1872514 |
1.00E-177 |
2.00E-45 |
1.00E-63 |
CT19426 |
Y65B4BR.I |
YJR036C |
| Aniridia-PAX6 |
106210 |
189353 |
6.00E-74 |
2.00E-93 |
3.00E-06 |
CT31252 |
F14F3.1 |
|
| Best Macular Dystrophy-VMD2 |
153700 |
4759310 |
1.00E-107 |
1.00E-85 |
3.10E+00 |
CT19608 |
C01B12.3 |
|
| Ceroid-Lipofuscinosis-PPT |
600722 |
1314355 |
6.00E-87 |
4.00E-87 |
1.00E+00 |
CT6387 |
F44C4.5 |
|
| Ceroid-Lipofuscinosis-CLN3 |
204200 |
2498243 |
1.00E-70 |
1.00E-68 |
2.00E-38 |
CT17650 |
F07B10.1 |
YJL059W |
| Ceroid-Lipofuscinosis-CLN2 |
204500 |
5729770 |
2.20E+00 |
1.60E+00 |
3.00E+00 |
|
|
|
| Charcot-Marie-Tooth 1A-PMP22 |
601097 |
266803 |
5.70E+00 |
1.90E+00 |
1.00E+00 |
|
|
|
| Charcot-Marie-Tooth 1B-MPZ |
159440 |
4505243 |
4.00E-01 |
9.00E-03 |
1.00E+00 |
|
|
|
| Choroideremia-CHM |
303100 |
2950156 |
2.00E-60 |
1.00E-29 |
2.00E-27 |
CT24497 |
Y57G11C.10 |
YER136W |
| Creutzfeldt-Jakob-PRNP |
176640 |
130912 |
1.00E+00 |
1.00E+00 |
1.00E+00 |
|
|
|
| Deafness, Hereditary-MYO15 |
602666 |
6224683 |
0.00E+00 |
1.00E-161 |
1.00E-133 |
CT7104 |
T10H10.1 |
YOR326W |
| Deafness, X-Linked-TIMM8A |
304700 |
4758152 |
6.00E-16 |
5.00E-12 |
2.00E-10 |
CT4964 |
Y39A3CR.E |
YJR135W- |
| Diaphanous 1-DIAPH1 |
602121 |
2947238 |
2.00E-95 |
1.00E-35 |
2.00E-13 |
CT4728 |
F56E10.2 |
YIL159W |
| Dementia, Multi-Infarct-NOTCH3 |
600276 |
4557799 |
0.00E+00 |
1.00E-111 |
2.00E-06 |
CT13012 |
Y64G10A.7 |
|
| Duchenne MD+-DMD |
310200 |
181857 |
1.00E-112 |
1.00E-146 |
0.005 |
CT22331 |
F32B4.3A |
|
| Emery-Dreifuss MD+-EMD |
310300 |
4557553 |
1.90E+00 |
7.00E-03 |
1.00E+00 |
|
|
|
| Emery-Dreifuss MD+-LMNA |
150330 |
5031875 |
2.00E-80 |
2.00E-46 |
4.00E-04 |
CT21503 |
F38B2.1 |
|
| Familial Encephalopathy-PI12 |
602445 |
1785654 |
2.00E-61 |
2.00E-51 |
1.60E+00 |
CT26788 |
C05E4.1 |
|
| Fragile-X-FRAXA |
309550 |
544328 |
9.00E-83 |
3.10E-02 |
4.50E-02 |
CT17036 |
|
|
| Friedreich Ataxia-FRDA |
229300 |
4503785 |
3.00E-28 |
2.00E-22 |
5.00E-13 |
CT25780 |
F59G1.7 |
YDL120W |
| Frontotemporal Dement.-TAU |
157140 |
3915884 |
4.00E-28 |
2.00E-22 |
7.60E-01 |
CT17716 |
F42G9.9 |
|
| Fukuyama MD+-FCMD |
253800 |
3370993 |
6.80E+00 |
2.00E-21 |
5.50E+00 |
|
T07D3.4 |
|
| Huntington-HD |
143100 |
1170192 |
3.00E-21 |
2.00E-03 |
3.10E-01 |
CT28171 |
|
|
| Limb Girdle MD+ 2A-CAPN3 |
114240 |
4557405 |
1.00E-171 |
1.00E-118 |
8.00E-10 |
CT23027 |
C06G4.2 |
YGR058W |
| Limb Girdle MD+ 2B-YSF |
603009 |
4503431 |
2.00E-94 |
1.00E-112 |
1.00E-04 |
CT18060 |
F43G9.6 |
|
| Limb Girdle MD+ 2E-BSG |
600900 |
1065401 |
3.00E-15 |
5.60E-02 |
1.00E+00 |
|
|
|
| Lissencephaly, X-Linked-DCX |
300121 |
6226810 |
8.00E-48 |
1.00E-56 |
3.50E-02 |
CT34154 |
Y79H2A.11 |
|
| Lowe Oculocerebroren.-OCRL |
309000 |
189356 |
1.00E-105 |
6.00E-75 |
8.00E-54 |
CT11908 |
C16C2.3 |
YNL106C |
| Machado-Joseph-MJD1 |
109150 |
833928 |
2.00E-06 |
9.00E-44 |
3.00E-03 |
|
F28F8.6 |
|
| Miller-Dieker Lissen.-PAF |
601545 |
349824 |
0.00E+00 |
1.00E-103 |
9.00E-37 |
CT36981 |
T03F6.5 |
YIL046W |
| Myotonic Dystrophy-DM1 |
160900 |
307177 |
1.00E-121 |
1.00E-126 |
5.00E-58 |
|
K08B12.5 |
YKL126W |
| Myotubular Myopathy 1-MTM1 |
310400 |
3912944 |
1.00E-57 |
4.00E-44 |
9.00E-29 |
CT12163 |
F53A2.8 |
YJR110W |
| Naito-Oyangi-DRPLA |
125370 |
1706519 |
2.00E-10 |
4.00E-03 |
9.00E-04 |
|
|
|
| Nemaline Myopathy 2-NEB |
161650 |
1082786 |
3.00E-12 |
4.00E-10 |
4.00E-03 |
|
F42H10.4 |
|
| Neuraminidase Defic.-NEU1 |
256550 |
4099141 |
1.00E+00 |
1.00E+00 |
1.00E+00 |
|
|
|
| Norrie-NDP |
310600 |
35017 |
9.90E-02 |
6.30E-01 |
1.00E+00 |
|
|
|
| Ocular Albinism-OA1 |
300500 |
1113125 |
2.80E-02 |
4.60E-02 |
8.50E+00 |
|
|
|
| Oculopharyngeal MD+-PABPN1 |
602279 |
4758876 |
9.00E-49 |
2.00E-41 |
3.00E-17 |
CT7068 |
C17E4.5 |
YIR001C |
| Oguchi Type 2-RHKIN |
180381 |
2833269 |
1.00E-118 |
1.00E-121 |
4.00E-52 |
CT40234 |
F19C6.1 |
YMR104C |
| Parkinson-SNCA |
163890 |
586067 |
1.80E+00 |
4.00E-02 |
9.80E+00 |
|
|
|
| Parkinson-PARK2 |
602544 |
4758884 |
1.00E-109 |
1.00E-41 |
1.00E-07 |
CT29531 |
K08E3.7 |
YKR017C |
| Parkinson-UCHL1 |
191342 |
4185720 |
7.00E-41 |
1.00E-24 |
1.00E-07 |
CT10917 |
F46E10.F |
YJR099W |
| Prog. Myoclonic Epilepsy-CSTB |
601145 |
1235678 |
1.90E+00 |
1.80E-02 |
5.80E+00 |
|
|
|
| Retinitis Pigmentosa-RPGR |
312610 |
2204218 |
9.00E-34 |
1.00E-19 |
9.00E-09 |
|
F07C3.4 |
YGL097W |
| Retinitis Pigmentosa 2-RP2 |
312600 |
3550283 |
1.00E-16 |
1.00E-06 |
7.90E-01 |
|
C54G6.2 |
|
| SCA* 1-SCA1 |
601556 |
1710863 |
1.00E-24 |
5.00E-20 |
8.70E-01 |
|
K04F10.1 |
|
| SCA* 2-SCA2 |
601517 |
1679684 |
4.00E-40 |
5.00E-09 |
2.00E-08 |
CT16521 |
D2045.1 |
YGR178C |
| SCA* 6-CACNA1A |
601011 |
4557399 |
0.00E+00 |
0.00E+00 |
1.00E-32 |
CT3905 |
T02D1.1 |
YGR218W |
| SCA* 7-SCA7 |
164500 |
5921169 |
2.00E-03 |