Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced


Supplemental Table 1. Comparative analysis of selected human disease genes against D. melanogaster (F), C. elegans (W), and S. cerevisiae (Y). OMIM numbers and GenBank identifiers for each of the disease genes included in the analysis. The BLAST e-value columns have the e-value for the top BLAST match. The database identifiers are the top BLAST match for worm and yeast matches, and the most likely ortholog for the fly matches. The identifiers represent the protein ids from the original sequencing center. These identifiers can be searched at CeleraScience.
        BLAST e-values     Database Identifiers  
Cancer OMIM Number Genbank Identifier for the human sequence F W Y F W Y
ABL1 189980 28237 0.00E+00 1.00E-162 4.00E-21 CT13380 M79.1B YMR001C
Acute Myeloid Leukemia-DEK 125264 4503249 1.00E-17 1.30E+00 1.90E+00 CT18411    
Adenomat. Polyposis Coli-APC 175100 182397 1.00E-135 6.00E-34 6.00E-05 CT3529 K04G2.9  
AKT2 164731 178326 1.00E-179 1.00E-162 3.00E-85 CT38917 C12D8.11 YKL127W
Ataxia Telangiectasia-ATM 208900 2304971 1.00E-145 2.00E-49 4.00E-92 CT20331 B0261.2 YBL088C
BRCA1 113705 555932 2.00E-06 9.00E-11 5.00E-05   C36A4.8  
BRCA2 600185 1161384 1.00E-03 2.00E+00 8.60E+00      
Basal Cell Nevus-PTC 601309 1381236 1.00E-128 8.00E-95 9.00E-16 CT7996 ZK675.1 YPL006W
B-Cell Lymphoma 2-BCL2 151430 179371 6.00E-06 1.00E+00 5.80E+00 CT24465    
B-Cell Lymphoma 3-BCL3 109560 179376 2.00E-28 4.00E-23 3.00E-08   C04F12.3 YIL112W
Bloom-BLM 210900 1072122 1.00E-148 1.00E-120 1.00E-109 CT21426 T04A11.6 YMR190C
Burkitt's Lymphoma-MYC 190080 386965 2.00E-09 4.00E-07 1.70E-02 CT10490 F46G10.6  
CDKN2C 600160 639716 5.00E-08 1.00E-08 6.00E-05   D2021.8  
CSF1R/C-Fms 164770 29900 7.00E-70 2.00E-63 3.00E-16   F58A3.2 YJL095W
Chk2 Protein Kinase 604373 6005850 8.00E-61 4.00E-58 2.00E-50 CT30511 Y60A3A YDL101C
PDGFB 190040 338211 7.00E-10 5.00E-04 1.50E+00      
CML-BCR 151410 29421 2.00E-99 2.00E-21 1.00E-16 CT40020 C38D4.5 YER155C
Cyclin D1-CCND1 168461 181245 6.00E-33 3.00E-20 4.00E-12 CT26100 Y38F1A.5 YGR108W
Cyclin Dep. Kinase 4-CDK4 123829 1353416 3.00E-72 2.00E-58 8.00E-55 CT16072 F18H3.5A YBR160W
EGFR 131550 757924 1.00E-134 1.00E-81 6.00E-18 CT28361 ZK1067.1 YOL113W
ERBB2 164870 306840 1.00E-114 2.00E-64 3.00E-14 CT28361 ZK1067.1 YOL113W
ETS 164720 182269 3.00E-32 2.00E-30 2.30E+00   C42D8.4  
E-Cadherin-CDH1 192090 31073 2.00E-32 2.00E-18 2.80E+00   R10F2.1  
Ewing Sarcoma-FLI-1 193067 32530 1.00E-59 6.00E-54 3.50E-01 CT21666 T08H4.3  
FGF3 164950 312409 2.00E-12 8.00E-16 7.40E+00   C05D11.4  
Fanconi's Anemia A-FANCA 227650 4503655 2.60E+00 8.50E-01 8.20E-02      
Fanconi's Anemia C-FANCC 227645 4557589 7.30E-01 5.40E-01 3.90E+00      
Fanconi's Anemia G-FANCG 602956 3860408 5.40E+00 3.90E+00 4.30E+00      
HNPCC*-MSH2 120435 433147 0.00E+00 1.00E-113 0.00E+00 CT11513 H26D21.2 YOL090W
HNPCC*-MSH3 600887 1490521 4.00E-67 2.00E-64 1.00E-126 CT21676 Y47G6A.11 YCR092C
HNPCC*-MSH6 600678 1294813 0.00E+00 0.00E+00 1.00E-135 CT21676 Y47G6A.11 YDR097C
HNPCC*-MLH1 120436 466462 0.00E+00 1.00E-106 1.00E-138 CT36319 T28A8.7 YMR167W
HNPCC*-PMS2 600259 535515 0.00E+00 1.00E-124 1.00E-124 CT21953 H12C20.2A YNL082W
KIT 164920 34085 6.00E-65 1.00E-61 4.00E-17   F58A3.2 YJL095W
LCK 153390 187034 1.00E-143 1.00E-116 5.00E-21   F49B2.5 YAR019C
Lymphoma-MCF2 311030 30482 4.00E-46 4.00E-32 4.00E-06 CT29242 C14A11.3  
MADH4 600993 1163234 1.00E-101 2.00E-39 1.50E-01 CT5334 R12B2.1  
MDM2 164785 266516 2.00E-03 1.00E-06 9.00E-03   F10D7.5  
MET 164860 307196 6.00E-53 1.00E-68 9.00E-22   F11E6.8 YAR019C
MEN1 131100 6166545 1.00E-99 5.90E-01 1.00E+00 CT33266    
MEN2A-RET 171400 547807 1.00E-111 2.00E-71 7.00E-20 CT1245 F58A3.2 YAR019C
Multiple Exostosis 1-EXT1 133700 1168162 0.00E+00 7.00E-74 1.00E+00 CT28467 F12F6.3  
Multiple Exostosis 2-EXT2 133701 3023739 0.00E+00 1.00E-60 1.00E-02 CT18005 K01G5.6  
NTRK1 191315 339918 5.00E-74 4.00E-55 4.00E-20   C01G6.8 YDR122W
Neurofibromatosis 1-NF1 162200 292354 0.00E+00 1.00E-22 1.00E-64 CT24543 ZK899.8G YBR140C
Neurofibromatosis 2-NF2 101000 292292 1.00E-147 1.00E-123 3.00E-03 CT33843 C01G8.5A  
Nijmegen Breakage 1-NBS1 602667 3126795 1.00E-34 1.00E-04 5.00E-07 CT20975   YDL058W
Nucleoporin-NUP214 114350 548384 7.00E-42 6.00E-23 2.00E-12 CT12729 C03D6.4 YIR019C
P16-INK4 600160 558657 2.00E-07 1.00E-05 1.00E-04      
P16-INK4A 600160 4502749 2.00E-07 1.00E+05 1.00E-04      
P19 ARF 600160 1000571 1.00E+00 1.00E+00 1.00E+00      
P53 191170 35214 2.00E-08 0.81 1 CT30451    
PTEN 601728 2811005 3.00E-73 5.00E-47 8.00E-17 CT17882 T07A9.6 YNL128W
RAS 190020 190891 2.00E-74 1.00E-72 7.00E-49 CT26623 ZK792.6 YOR101W
REL 164910 402649 2.00E-68 1.50E-01 3.80E-01 CT20694    
Retinoblastoma-RB1 180200 190959 1.00E-35 5.00E-22 7.60E-01 CT22763 C32F10.2  
STK11 602216 2791676 1.00E-106 1.00E-34 8.00E-35 CT26569 W03G1.6 YDR477W
Stem Cell Leukemia-TAL1 187040 337970 5.00E-22 2.00E-09 1.00E+00 CT8939 T15H9.3  
Tuberous Sclerosis 1-TSC1 191100 2331281 2.00E-43 8.00E-08 4.00E-08 CT19312 F07A5.7 YDR356W
Tuberous Sclerosis 2-TSC2 191092 4071058 1.00E-144 2.00E-14 7.70E+00 CT21583 F47F6.7  
Von Hippel Lindau-VHL 193300 2282064 1.00E-02 3.00E-03 3.80E+00      
Wilm's Tumor-WT1 194070 139778 4.00E-28 3.00E-28 9.00E-21   F56F11.3 YOR113W
Xeroderma Pigment. A-XPA 278700 139816 2.00E-50 3.00E-39 1.00E-13 CT19848 K07G5.2 YMR201C
Xeroderma Pigment. B-ERCC3 133510 119541 0.00E+00 2.60E-01 0.00E+00 CT24084   YIL143C
Xeroderma Pigment. D-XPD 278730 119540 0.00E+00 6.00E-52 0.00E+00 CT26722 F25H2.13 YER171W
Xeroderma Pigment. F-XPF 278760 2842712 8.00E-93 1.00E-49 1.00E-60 CT12377 VF13D12L.2 YPL022W
Xeroderma Pigment. G-XPG 278780 267420 1.00E-64 8.00E-23 6.00E-47 CT30499 F57B10.6 YGR258C
                 
Neurological                
Adrenoleukodystrophy-ABCD1 300100 38591 0.00E+00 0.00E+00 7.00E-93 CT7456 T02D1.5 YPL147W
Alzheimer-PS1 104311 1709856 1.00E-96 5.00E-85 3.20E+00 CT18359 F35H12.3  
Alzheimer-APP 104760 2429081 3.00E-22 2.00E-36 1.00E-04 CT23451 C42D8.8  
Amyotrophic Lat. Sclero.-SOD1 147450 338276 9.00E-51 1.00E-46 2.00E-44 CT36899 C15F1.7 YJR104C
Angelman-UBE3A 601623 1872514 1.00E-177 2.00E-45 1.00E-63 CT19426 Y65B4BR.I YJR036C
Aniridia-PAX6 106210 189353 6.00E-74 2.00E-93 3.00E-06 CT31252 F14F3.1  
Best Macular Dystrophy-VMD2 153700 4759310 1.00E-107 1.00E-85 3.10E+00 CT19608 C01B12.3  
Ceroid-Lipofuscinosis-PPT 600722 1314355 6.00E-87 4.00E-87 1.00E+00 CT6387 F44C4.5  
Ceroid-Lipofuscinosis-CLN3 204200 2498243 1.00E-70 1.00E-68 2.00E-38 CT17650 F07B10.1 YJL059W
Ceroid-Lipofuscinosis-CLN2 204500 5729770 2.20E+00 1.60E+00 3.00E+00      
Charcot-Marie-Tooth 1A-PMP22 601097 266803 5.70E+00 1.90E+00 1.00E+00      
Charcot-Marie-Tooth 1B-MPZ 159440 4505243 4.00E-01 9.00E-03 1.00E+00      
Choroideremia-CHM 303100 2950156 2.00E-60 1.00E-29 2.00E-27 CT24497 Y57G11C.10 YER136W
Creutzfeldt-Jakob-PRNP 176640 130912 1.00E+00 1.00E+00 1.00E+00      
Deafness, Hereditary-MYO15 602666 6224683 0.00E+00 1.00E-161 1.00E-133 CT7104 T10H10.1 YOR326W
Deafness, X-Linked-TIMM8A 304700 4758152 6.00E-16 5.00E-12 2.00E-10 CT4964 Y39A3CR.E YJR135W-
Diaphanous 1-DIAPH1 602121 2947238 2.00E-95 1.00E-35 2.00E-13 CT4728 F56E10.2 YIL159W
Dementia, Multi-Infarct-NOTCH3 600276 4557799 0.00E+00 1.00E-111 2.00E-06 CT13012 Y64G10A.7  
Duchenne MD+-DMD 310200 181857 1.00E-112 1.00E-146 0.005 CT22331 F32B4.3A  
Emery-Dreifuss MD+-EMD 310300 4557553 1.90E+00 7.00E-03 1.00E+00      
Emery-Dreifuss MD+-LMNA 150330 5031875 2.00E-80 2.00E-46 4.00E-04 CT21503 F38B2.1  
Familial Encephalopathy-PI12 602445 1785654 2.00E-61 2.00E-51 1.60E+00 CT26788 C05E4.1  
Fragile-X-FRAXA 309550 544328 9.00E-83 3.10E-02 4.50E-02 CT17036    
Friedreich Ataxia-FRDA 229300 4503785 3.00E-28 2.00E-22 5.00E-13 CT25780 F59G1.7 YDL120W
Frontotemporal Dement.-TAU 157140 3915884 4.00E-28 2.00E-22 7.60E-01 CT17716 F42G9.9  
Fukuyama MD+-FCMD 253800 3370993 6.80E+00 2.00E-21 5.50E+00   T07D3.4  
Huntington-HD 143100 1170192 3.00E-21 2.00E-03 3.10E-01 CT28171    
Limb Girdle MD+ 2A-CAPN3 114240 4557405 1.00E-171 1.00E-118 8.00E-10 CT23027 C06G4.2 YGR058W
Limb Girdle MD+ 2B-YSF 603009 4503431 2.00E-94 1.00E-112 1.00E-04 CT18060 F43G9.6  
Limb Girdle MD+ 2E-BSG 600900 1065401 3.00E-15 5.60E-02 1.00E+00      
Lissencephaly, X-Linked-DCX 300121 6226810 8.00E-48 1.00E-56 3.50E-02 CT34154 Y79H2A.11  
Lowe Oculocerebroren.-OCRL 309000 189356 1.00E-105 6.00E-75 8.00E-54 CT11908 C16C2.3 YNL106C
Machado-Joseph-MJD1 109150 833928 2.00E-06 9.00E-44 3.00E-03   F28F8.6  
Miller-Dieker Lissen.-PAF 601545 349824 0.00E+00 1.00E-103 9.00E-37 CT36981 T03F6.5 YIL046W
Myotonic Dystrophy-DM1 160900 307177 1.00E-121 1.00E-126 5.00E-58   K08B12.5 YKL126W
Myotubular Myopathy 1-MTM1 310400 3912944 1.00E-57 4.00E-44 9.00E-29 CT12163 F53A2.8 YJR110W
Naito-Oyangi-DRPLA 125370 1706519 2.00E-10 4.00E-03 9.00E-04      
Nemaline Myopathy 2-NEB 161650 1082786 3.00E-12 4.00E-10 4.00E-03   F42H10.4  
Neuraminidase Defic.-NEU1 256550 4099141 1.00E+00 1.00E+00 1.00E+00      
Norrie-NDP 310600 35017 9.90E-02 6.30E-01 1.00E+00      
Ocular Albinism-OA1 300500 1113125 2.80E-02 4.60E-02 8.50E+00      
Oculopharyngeal MD+-PABPN1 602279 4758876 9.00E-49 2.00E-41 3.00E-17 CT7068 C17E4.5 YIR001C
Oguchi Type 2-RHKIN 180381 2833269 1.00E-118 1.00E-121 4.00E-52 CT40234 F19C6.1 YMR104C
Parkinson-SNCA 163890 586067 1.80E+00 4.00E-02 9.80E+00      
Parkinson-PARK2 602544 4758884 1.00E-109 1.00E-41 1.00E-07 CT29531 K08E3.7 YKR017C
Parkinson-UCHL1 191342 4185720 7.00E-41 1.00E-24 1.00E-07 CT10917 F46E10.F YJR099W
Prog. Myoclonic Epilepsy-CSTB 601145 1235678 1.90E+00 1.80E-02 5.80E+00      
Retinitis Pigmentosa-RPGR 312610 2204218 9.00E-34 1.00E-19 9.00E-09   F07C3.4 YGL097W
Retinitis Pigmentosa 2-RP2 312600 3550283 1.00E-16 1.00E-06 7.90E-01   C54G6.2  
SCA* 1-SCA1 601556 1710863 1.00E-24 5.00E-20 8.70E-01   K04F10.1  
SCA* 2-SCA2 601517 1679684 4.00E-40 5.00E-09 2.00E-08 CT16521 D2045.1 YGR178C
SCA* 6-CACNA1A 601011 4557399 0.00E+00 0.00E+00 1.00E-32 CT3905 T02D1.1 YGR218W
SCA* 7-SCA7 164500 5921169 2.00E-03