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Supplemental Table 1. Comparative analysis of selected human disease genes against D. melanogaster (F), C. elegans (W), and S. cerevisiae (Y). OMIM numbers and GenBank identifiers for each of the disease genes included in the analysis. The BLAST e-value columns have the e-value for the top BLAST match. The database identifiers are the top BLAST match for worm and yeast matches, and the most likely ortholog for the fly matches. The identifiers represent the protein ids from the original sequencing center. These identifiers can be searched at CeleraScience.
        BLAST e-values     Database Identifiers  
Cancer OMIM Number Genbank Identifier for the human sequence F W Y F W Y
ABL1 189980 28237 0.00E+00 1.00E-162 4.00E-21 CT13380 M79.1B YMR001C
Acute Myeloid Leukemia-DEK 125264 4503249 1.00E-17 1.30E+00 1.90E+00 CT18411    
Adenomat. Polyposis Coli-APC 175100 182397 1.00E-135 6.00E-34 6.00E-05 CT3529 K04G2.9  
AKT2 164731 178326 1.00E-179 1.00E-162 3.00E-85 CT38917 C12D8.11 YKL127W
Ataxia Telangiectasia-ATM 208900 2304971 1.00E-145 2.00E-49 4.00E-92 CT20331 B0261.2 YBL088C
BRCA1 113705 555932 2.00E-06 9.00E-11 5.00E-05   C36A4.8  
BRCA2 600185 1161384 1.00E-03 2.00E+00 8.60E+00      
Basal Cell Nevus-PTC 601309 1381236 1.00E-128 8.00E-95 9.00E-16 CT7996 ZK675.1 YPL006W
B-Cell Lymphoma 2-BCL2 151430 179371 6.00E-06 1.00E+00 5.80E+00 CT24465    
B-Cell Lymphoma 3-BCL3 109560 179376 2.00E-28 4.00E-23 3.00E-08   C04F12.3 YIL112W
Bloom-BLM 210900 1072122 1.00E-148 1.00E-120 1.00E-109 CT21426 T04A11.6 YMR190C
Burkitt's Lymphoma-MYC 190080 386965 2.00E-09 4.00E-07 1.70E-02 CT10490 F46G10.6  
CDKN2C 600160 639716 5.00E-08 1.00E-08 6.00E-05   D2021.8  
CSF1R/C-Fms 164770 29900 7.00E-70 2.00E-63 3.00E-16   F58A3.2 YJL095W
Chk2 Protein Kinase 604373 6005850 8.00E-61 4.00E-58 2.00E-50 CT30511 Y60A3A YDL101C
PDGFB 190040 338211 7.00E-10 5.00E-04 1.50E+00      
CML-BCR 151410 29421 2.00E-99 2.00E-21 1.00E-16 CT40020 C38D4.5 YER155C
Cyclin D1-CCND1 168461 181245 6.00E-33 3.00E-20 4.00E-12 CT26100 Y38F1A.5 YGR108W
Cyclin Dep. Kinase 4-CDK4 123829 1353416 3.00E-72 2.00E-58 8.00E-55 CT16072 F18H3.5A YBR160W
EGFR 131550 757924 1.00E-134 1.00E-81 6.00E-18 CT28361 ZK1067.1 YOL113W
ERBB2 164870 306840 1.00E-114 2.00E-64 3.00E-14 CT28361 ZK1067.1 YOL113W
ETS 164720 182269 3.00E-32 2.00E-30 2.30E+00   C42D8.4  
E-Cadherin-CDH1 192090 31073 2.00E-32 2.00E-18 2.80E+00   R10F2.1  
Ewing Sarcoma-FLI-1 193067 32530 1.00E-59 6.00E-54 3.50E-01 CT21666 T08H4.3  
FGF3 164950 312409 2.00E-12 8.00E-16 7.40E+00   C05D11.4  
Fanconi's Anemia A-FANCA 227650 4503655 2.60E+00 8.50E-01 8.20E-02      
Fanconi's Anemia C-FANCC 227645 4557589 7.30E-01 5.40E-01 3.90E+00      
Fanconi's Anemia G-FANCG 602956 3860408 5.40E+00 3.90E+00 4.30E+00      
HNPCC*-MSH2 120435 433147 0.00E+00 1.00E-113 0.00E+00 CT11513 H26D21.2 YOL090W
HNPCC*-MSH3 600887 1490521 4.00E-67 2.00E-64 1.00E-126 CT21676 Y47G6A.11 YCR092C
HNPCC*-MSH6 600678 1294813 0.00E+00 0.00E+00 1.00E-135 CT21676 Y47G6A.11 YDR097C
HNPCC*-MLH1 120436 466462 0.00E+00 1.00E-106 1.00E-138 CT36319 T28A8.7 YMR167W
HNPCC*-PMS2 600259 535515 0.00E+00 1.00E-124 1.00E-124 CT21953 H12C20.2A YNL082W
KIT 164920 34085 6.00E-65 1.00E-61 4.00E-17   F58A3.2 YJL095W
LCK 153390 187034 1.00E-143 1.00E-116 5.00E-21   F49B2.5 YAR019C
Lymphoma-MCF2 311030 30482 4.00E-46 4.00E-32 4.00E-06 CT29242 C14A11.3  
MADH4 600993 1163234 1.00E-101 2.00E-39 1.50E-01 CT5334 R12B2.1  
MDM2 164785 266516 2.00E-03 1.00E-06 9.00E-03   F10D7.5  
MET 164860 307196 6.00E-53 1.00E-68 9.00E-22   F11E6.8 YAR019C
MEN1 131100 6166545 1.00E-99 5.90E-01 1.00E+00 CT33266    
MEN2A-RET 171400 547807 1.00E-111 2.00E-71 7.00E-20 CT1245 F58A3.2 YAR019C
Multiple Exostosis 1-EXT1 133700 1168162 0.00E+00 7.00E-74 1.00E+00 CT28467 F12F6.3  
Multiple Exostosis 2-EXT2 133701 3023739 0.00E+00 1.00E-60 1.00E-02 CT18005 K01G5.6  
NTRK1 191315 339918 5.00E-74 4.00E-55 4.00E-20   C01G6.8 YDR122W
Neurofibromatosis 1-NF1 162200 292354 0.00E+00 1.00E-22 1.00E-64 CT24543 ZK899.8G YBR140C
Neurofibromatosis 2-NF2 101000 292292 1.00E-147 1.00E-123 3.00E-03 CT33843 C01G8.5A  
Nijmegen Breakage 1-NBS1 602667 3126795 1.00E-34 1.00E-04 5.00E-07 CT20975   YDL058W
Nucleoporin-NUP214 114350 548384 7.00E-42 6.00E-23 2.00E-12 CT12729 C03D6.4 YIR019C
P16-INK4 600160 558657 2.00E-07 1.00E-05 1.00E-04      
P16-INK4A 600160 4502749 2.00E-07 1.00E+05 1.00E-04      
P19 ARF 600160 1000571 1.00E+00 1.00E+00 1.00E+00      
P53 191170 35214 2.00E-08 0.81 1 CT30451    
PTEN 601728 2811005 3.00E-73 5.00E-47 8.00E-17 CT17882 T07A9.6 YNL128W
RAS 190020 190891 2.00E-74 1.00E-72 7.00E-49 CT26623 ZK792.6 YOR101W
REL 164910 402649 2.00E-68 1.50E-01 3.80E-01 CT20694    
Retinoblastoma-RB1 180200 190959 1.00E-35 5.00E-22 7.60E-01 CT22763 C32F10.2  
STK11 602216 2791676 1.00E-106 1.00E-34 8.00E-35 CT26569 W03G1.6 YDR477W
Stem Cell Leukemia-TAL1 187040 337970 5.00E-22 2.00E-09 1.00E+00 CT8939 T15H9.3  
Tuberous Sclerosis 1-TSC1 191100 2331281 2.00E-43 8.00E-08 4.00E-08 CT19312 F07A5.7 YDR356W
Tuberous Sclerosis 2-TSC2 191092 4071058 1.00E-144 2.00E-14 7.70E+00 CT21583 F47F6.7  
Von Hippel Lindau-VHL 193300 2282064 1.00E-02 3.00E-03 3.80E+00      
Wilm's Tumor-WT1 194070 139778 4.00E-28 3.00E-28 9.00E-21   F56F11.3 YOR113W
Xeroderma Pigment. A-XPA 278700 139816 2.00E-50 3.00E-39 1.00E-13 CT19848 K07G5.2 YMR201C
Xeroderma Pigment. B-ERCC3 133510 119541 0.00E+00 2.60E-01 0.00E+00 CT24084   YIL143C
Xeroderma Pigment. D-XPD 278730 119540 0.00E+00 6.00E-52 0.00E+00 CT26722 F25H2.13 YER171W
Xeroderma Pigment. F-XPF 278760 2842712 8.00E-93 1.00E-49 1.00E-60 CT12377 VF13D12L.2 YPL022W
Xeroderma Pigment. G-XPG 278780 267420 1.00E-64 8.00E-23 6.00E-47 CT30499 F57B10.6 YGR258C
                 
Neurological                
Adrenoleukodystrophy-ABCD1 300100 38591 0.00E+00 0.00E+00 7.00E-93 CT7456 T02D1.5 YPL147W
Alzheimer-PS1 104311 1709856 1.00E-96 5.00E-85 3.20E+00 CT18359 F35H12.3  
Alzheimer-APP 104760 2429081 3.00E-22 2.00E-36 1.00E-04 CT23451 C42D8.8  
Amyotrophic Lat. Sclero.-SOD1 147450 338276 9.00E-51 1.00E-46 2.00E-44 CT36899 C15F1.7 YJR104C
Angelman-UBE3A 601623 1872514 1.00E-177 2.00E-45 1.00E-63 CT19426 Y65B4BR.I YJR036C
Aniridia-PAX6 106210 189353 6.00E-74 2.00E-93 3.00E-06 CT31252 F14F3.1  
Best Macular Dystrophy-VMD2 153700 4759310 1.00E-107 1.00E-85 3.10E+00 CT19608 C01B12.3  
Ceroid-Lipofuscinosis-PPT 600722 1314355 6.00E-87 4.00E-87 1.00E+00 CT6387 F44C4.5  
Ceroid-Lipofuscinosis-CLN3 204200 2498243 1.00E-70 1.00E-68 2.00E-38 CT17650 F07B10.1 YJL059W
Ceroid-Lipofuscinosis-CLN2 204500 5729770 2.20E+00 1.60E+00 3.00E+00      
Charcot-Marie-Tooth 1A-PMP22 601097 266803 5.70E+00 1.90E+00 1.00E+00      
Charcot-Marie-Tooth 1B-MPZ 159440 4505243 4.00E-01 9.00E-03 1.00E+00      
Choroideremia-CHM 303100 2950156 2.00E-60 1.00E-29 2.00E-27 CT24497 Y57G11C.10 YER136W
Creutzfeldt-Jakob-PRNP 176640 130912 1.00E+00 1.00E+00 1.00E+00      
Deafness, Hereditary-MYO15 602666 6224683 0.00E+00 1.00E-161 1.00E-133 CT7104 T10H10.1 YOR326W
Deafness, X-Linked-TIMM8A 304700 4758152 6.00E-16 5.00E-12 2.00E-10 CT4964 Y39A3CR.E YJR135W-
Diaphanous 1-DIAPH1 602121 2947238 2.00E-95 1.00E-35 2.00E-13 CT4728 F56E10.2 YIL159W
Dementia, Multi-Infarct-NOTCH3 600276 4557799 0.00E+00 1.00E-111 2.00E-06 CT13012 Y64G10A.7  
Duchenne MD+-DMD 310200 181857 1.00E-112 1.00E-146 0.005 CT22331 F32B4.3A  
Emery-Dreifuss MD+-EMD 310300 4557553 1.90E+00 7.00E-03 1.00E+00      
Emery-Dreifuss MD+-LMNA 150330 5031875 2.00E-80 2.00E-46 4.00E-04 CT21503 F38B2.1  
Familial Encephalopathy-PI12 602445 1785654 2.00E-61 2.00E-51 1.60E+00 CT26788 C05E4.1  
Fragile-X-FRAXA 309550 544328 9.00E-83 3.10E-02 4.50E-02 CT17036    
Friedreich Ataxia-FRDA 229300 4503785 3.00E-28 2.00E-22 5.00E-13 CT25780 F59G1.7 YDL120W
Frontotemporal Dement.-TAU 157140 3915884 4.00E-28 2.00E-22 7.60E-01 CT17716 F42G9.9  
Fukuyama MD+-FCMD 253800 3370993 6.80E+00 2.00E-21 5.50E+00   T07D3.4  
Huntington-HD 143100 1170192 3.00E-21 2.00E-03 3.10E-01 CT28171    
Limb Girdle MD+ 2A-CAPN3 114240 4557405 1.00E-171 1.00E-118 8.00E-10 CT23027 C06G4.2 YGR058W
Limb Girdle MD+ 2B-YSF 603009 4503431 2.00E-94 1.00E-112 1.00E-04 CT18060 F43G9.6  
Limb Girdle MD+ 2E-BSG 600900 1065401 3.00E-15 5.60E-02 1.00E+00      
Lissencephaly, X-Linked-DCX 300121 6226810 8.00E-48 1.00E-56 3.50E-02 CT34154 Y79H2A.11  
Lowe Oculocerebroren.-OCRL 309000 189356 1.00E-105 6.00E-75 8.00E-54 CT11908 C16C2.3 YNL106C
Machado-Joseph-MJD1 109150 833928 2.00E-06 9.00E-44 3.00E-03   F28F8.6  
Miller-Dieker Lissen.-PAF 601545 349824 0.00E+00 1.00E-103 9.00E-37 CT36981 T03F6.5 YIL046W
Myotonic Dystrophy-DM1 160900 307177 1.00E-121 1.00E-126 5.00E-58   K08B12.5 YKL126W
Myotubular Myopathy 1-MTM1 310400 3912944 1.00E-57 4.00E-44 9.00E-29 CT12163 F53A2.8 YJR110W
Naito-Oyangi-DRPLA 125370 1706519 2.00E-10 4.00E-03 9.00E-04      
Nemaline Myopathy 2-NEB 161650 1082786 3.00E-12 4.00E-10 4.00E-03   F42H10.4  
Neuraminidase Defic.-NEU1 256550 4099141 1.00E+00 1.00E+00 1.00E+00      
Norrie-NDP 310600 35017 9.90E-02 6.30E-01 1.00E+00      
Ocular Albinism-OA1 300500 1113125 2.80E-02 4.60E-02 8.50E+00      
Oculopharyngeal MD+-PABPN1 602279 4758876 9.00E-49 2.00E-41 3.00E-17 CT7068 C17E4.5 YIR001C
Oguchi Type 2-RHKIN 180381 2833269 1.00E-118 1.00E-121 4.00E-52 CT40234 F19C6.1 YMR104C
Parkinson-SNCA 163890 586067 1.80E+00 4.00E-02 9.80E+00      
Parkinson-PARK2 602544 4758884 1.00E-109 1.00E-41 1.00E-07 CT29531 K08E3.7 YKR017C
Parkinson-UCHL1 191342 4185720 7.00E-41 1.00E-24 1.00E-07 CT10917 F46E10.F YJR099W
Prog. Myoclonic Epilepsy-CSTB 601145 1235678 1.90E+00 1.80E-02 5.80E+00      
Retinitis Pigmentosa-RPGR 312610 2204218 9.00E-34 1.00E-19 9.00E-09   F07C3.4 YGL097W
Retinitis Pigmentosa 2-RP2 312600 3550283 1.00E-16 1.00E-06 7.90E-01   C54G6.2  
SCA* 1-SCA1 601556 1710863 1.00E-24 5.00E-20 8.70E-01   K04F10.1  
SCA* 2-SCA2 601517 1679684 4.00E-40 5.00E-09 2.00E-08 CT16521 D2045.1 YGR178C
SCA* 6-CACNA1A 601011 4557399 0.00E+00 0.00E+00 1.00E-32 CT3905 T02D1.1 YGR218W
SCA* 7-SCA7 164500 5921169 2.00E-03 2.00E-02 5.00E-06      
Spinal Muscular Atrophy-SMN1 600354 624186 5.00E-07 1.00E-04 1.00E+00 CT13648    
Stargardt's-ABCA4 601691 1888527 1.00E-119 2.00E-95 4.00E-14 CT4892 Y39D8C.1 YOR328W
Tay-Sachs-HEXA 272800 123079 1.00E-57 6.00E-99 8.30E+00 CT5190 T14F9.3  
Thomsen-CLCN1 118425 398161 1.00E-142 1.00E-141 6.00E-38 CT21521 E04F6.11 YJR040W
Usher-USH2A 276901 6005936 1.00E-106 1.00E-112 1.20E-01   K08C7.3  
Wilson-ATP7B 277900 4502323 0.00E+00 0.00E+00 1.00E-143 CT5824 Y76A2A.2 YDR270W
                 
Cardiovascular                
A/V Conduction Defects-CSX 600584 1708211 2.00E-26 2.00E-21 1.20E-02 CT19338 F55B12.1  
HDL Deficiency 1-ABCA1 600046 5915658 1.00E-127 1.00E-103 7.00E-13 CT4892 Y39D8C.1 YOL075C
Long Q-T 1-KCNQ1 192500 2465515 8.00E-64 1.00E-100 1.40E+00 CT11429    
Long Q-T 2-KCNH2 152427 4156239 0.00E+00 0.00E+00 3.30E-01 CT10669 C30D11.1  
Long Q-T 3-SCN5A 600163 4506809 0.00E+00 1.00E-64 1.00E-17 CT27902 C48A7.1 YGR217W
Fam. Cardiac Myopathy-MYH7 160760 547966 0.00E+00 0.00E+00 0.00E+00 CT39920 F11C3.3 YHR023W
                 
Malformation Syndromes                
Aarskog-Scott-FGD1 305400 4758358 4.00E-23 3.00E-60 6.00E-06   C33D9.1  
Achondroplasia-FGFR3 134934 4503711 1.00E-129 1.00E-114 9.00E-22 CT22273 F58A3.2 YAR019C
Alagille-JAG1 601920 4557679 1.00E-169 1.00E-90 8.00E-03 CT18858 R107.8  
Barth-TAZ 302060 1263132 3.00E-61 8.00E-52 2.00E-15 CT25282 ZK809.2 YPR140W
Beckwith-Wiedemann-CDKN1C 600856 790248 1.00E+00 8.00E-08 1.00E+00   T05A6.2  
Cerebral Cavern. Malf.-CCM1 604214 2832226 2.00E-01 5.00E-05 4.20E+00      
Chondrodyspl. Punct. 1-ARSE 300180 791004 2.00E-24 3.00E-34 1.00E+00 CT22761 D1014.1  
Cleidocranial Dysplasia-OFC1 119600 5724787 7.00E-56 3.00E-32 1.60E-02 CT2976 B0414.2  
Cockayne I-CKN1 216400 3121917 5.00E-14 4.00E-13 1.00E-14   K07A1.12 YDR030C
Coffin-Lowry-RPS6KA3 300075 1730070 0.00E+00 0.00E+00 1.00E-66 CT34367 T01H8.1A YHR205W
Diastrophic Dyspl.-SLC26A2 222600 1706534 6.00E-72 3.00E-80 6.00E-33 CT17394 K12G11.2 YBR294W
EEC 3-Ket., P63 603273 3970717 2.00E-11 2.00E-03 4.00E-03 CT30451    
Greig Cephalopolysynd.-GLI3 165240 4504015 6.00E-94 1.00E-57 2.00E-26 CT6641 Y47D3A.7 YJL056C
Hand-Foot-Genital-HOXA13 142959 1832353 4.00E-12 4.00E-13 5.00E-04   Y75B8A.1  
Holoprosencephaly 3-SHH 600725 6094283 3.00E-68 3.00E-09 1.00E+00 CT14986 ZK678.5  
Holoprosencephaly-SIX3 603714 4885597 2.00E-88 8.00E-70 7.00E-06 CT42028 W05E10.3  
Holt-Oram-TBX5 601620 1772561 6.00E-61 7.00E-64 2.10E+00 CT12025 F21H11.3  
ICF-DNMT3B 602900 5901940 9.00E-07 9.70E-02 2.10E+00      
Kallman-KAL1 308700 125183 1.00E-29 4.00E-32 6.30E+00 CT19368 F31D5.2  
Laterality, X-Linked-ZIC3 306955 2957266 5.00E-81 5.00E-49 2.00E-27   C47C12.3 YJL056C
Melnick-Fraser-EYA1 601653 4503619 1.00E-113 6.00E-19 3.00E-03 CT27024 C49A1.4  
Nail Patella-LMX1B 602575 3132909 2.00E-53 1.00E-40 3.00E-07 CT29296 F46C8.5 YDR379W
Opitz-MID1 300000 4557753 3.00E-15 2.00E-13 1.60E-02   ZK1320.6  
Renal Coloboma-PAX2 120330 1469415 2.00E-62 1.00E-56 1.10E-01 CT30911 F14F3.1  
Rieger , Type 1-PITX2 601542 4505827 1.00E-42 2.00E-25 8.00E-09 CT3485 B0564.10 YDL106C
Rubinstein-Taybi-CREBBP 600140 1888538 3.30E-01 4.80E+00 1.00E+00      
Saethre-Chotzen-TWIST 601622 4507741 2.00E-23 3.00E-09 1.50E+00 CT10023 C34E10.7  
Septooptic Dysplasia-HESX1 601802 4504367 3.00E-14 2.00E-13 1.00E-05   Y113G7A.6A  
Simpson-Golabi-Behmel-GPC3 300037 1237181 8.00E-24 1.00E-21 1.00E+00 CT15952 F59D12.4  
Townes-Brockes-SALL1 602218 4688925 1.00E-70 4.00E-42 3.00E-14 CT15643 F15C11.1 YOR113W
Treacher-Collins-TCOF1 154500 1736917 7.00E-06 5.00E-05 5.20E-01      
VMCM-TEK 600221 464868 6.00E-63 7.00E-62 1.00E-17   F58A3.2 YAR019C
Wardenburg-PAX3 193500 435421 1.00E-30 1.00E-22 2.00E-09 CT20859 R08B4.2 YDL140C
Zellweger-PEX1 602136 2655141 3.00E-81 2.00E-67 7.00E-91 CT20911 C06A1.1 YKL197C
                 
Endocrine                
Adrenal Hypoplasia-NR0B1 300200 5016090 3.00E-12 2.00E-01 9.60E+00      
Androgen Receptor-AR 313700 113830 3.00E-29 4.00E-23 8.70E+00   C02B4.2  
Adrenal Hyperplas. III-CYP21A2 201910 180964 1.00E-43 2.00E-34 1.00E-08   F42A9.5 YHR007C
Diabetes-INS 176730 124617 3.40E-02 9.70E+00 1.00E+00 CT33771    
Diabetes-INSR 147670 124529 0.00E+00 2.00E-55 2.00E-18 CT19952 C01G6.8 YAR019C
Diabet. Ins. Neurohypop.-AVP 192340 4502329 2.10E-02 4.00E-03 1.00E+00      
Diabet. w/ Hypertens.-PPARG 601487 4826930 2.00E-29 4.00E-31 5.60E+00   F44A6.2  
Gonadal Dysgenesis-SRY 480000 1082784 5.00E-30 2.00E-31 2.00E-08   K08A8.2 YPR065W
Dwarfism-GH1 139250 4503989 2.70E+00 9.00E-01 9.90E-01      
Dwarfism-GHR 600946 4503993 3.00E-04 1.10E-02 1.70E-01      
Hyperinsulinism-ABCC8 600509 2506120 1.00E-160 1.00E-160 1.00E-176 CT23227 F21G4.2 YDR135C
Hyperinsulinism-KCNJ11 600937 2493608 1.00E-85 3.00E-78 7.70E+00 CT20955 M02A10.2  
Hypothyroidism-TRH 275120 135841 5.60E+00 1.40E+00 1.00E+00      
Hypothyroidism-SLC5A5 601843 4507035 1.00E-85 1.00E-63 8.00E-06 CT7152 ZK822.5  
Leydig Cell Hypoplasia-LHCGR 152790 4557717 1.00E-117 6.00E-76 8.50E+00 CT23429 C50H2.1  
MODY++ 1-HNF-4A 600281 6166208 1.00E-110 3.00E-69 7.10E+00 CT26497 C45E1.1  
MODY++ 2-GCK 138079 2773378 1.00E-112 1.00E-108 9.00E-68 CT4281 F14B4.2 YFR053C
MODY++ 3-TCF1 142410 4507393 6.00E-05 3.00E-06 3.00E-04      
MODY++ 4-IPF1 600733 4557673 4.00E-15 3.00E-14 8.00E-03   C07H6.7  
MODY++ 5-TCF2 189907 422866 1.00E-03 2.00E-03 5.00E-02      
McCune-Albright-GNAS1 139320 121002 1.00E-163 1.00E-153 1.00E-50 CT9680 R06A10.2 YER020W
Non-Insulin Dep. Diabet.-PCSK1 162150 1660988 1.00E-163 1.00E-152 8.00E-99 CT30202 F11A6.1A YNL238W
Obesity-LEP 164160 4557715 4.00E-01 1.70E-01 1.90E-01      
Obesity-LEPR 601007 4504979 6.20E-02 3.50E-02 2.90E+00      
Obesity-MC4R 155541 5174533 3.00E-12 2.00E-10 4.90E+00   C50F7.1  
Obesity-POMC 176830 4505949 1.00E+00 1.00E+00 1.00E+00      
Pendred-PDS 274600 4505697 3.00E-58 3.00E-66 3.20E+00 CT17394 K12G11.2  
Thyroid Resistance-THRA 190120 135702 7.00E-47 4.00E-26 2.10E+00   F44A6.2  
Thyroid Resistance-THRB 190160 586095 2.00E-30 6.00E-24 4.30E+00   T23H4.2  
Thyrotropin Deficiency-TSHB 188540 339998 3.70E+00 1.60E+00 1.00E+00      
Vitamin-D Resis. Rickets-VDR 601769 4507883 5.00E-25 2.00E-24 1.50E-01 CT33046 F11A1.3  
                 
                 
Renal                
Alport-COL4A5 303630 2144805 6.00E-75 4.00E-98 9.70E-02 CT25584 W03G11.1  
Bartter's-SLC12A1 600839 4557849 0.00E+00 1.00E-166 1.00E-58 CT14159 Y37A1C.1A YBR235W
Congenital Nephrotic-NPHS1 602716 3025699 1.00E-116 3.00E-63 6.90E+00 CT22841 C26G2.1  
Dents-CLCN5 300008 4557473 0.00E+00 0.00E+00 3.00E-74 CT16841 C07H4.2 YJR040W
Diabetes Insipidus 2-AQP2 107777 4502179 6.00E-35 6.00E-17 1.00E-16 CT23658 C32C4.2 YPR192W
Gitelmans-SLC12A3 600968 1717801 0.00E+00 1.00E-167 1.00E-64 CT14159 Y37A1C.1A YBR235W
1º Hyperoxaluria I-AGXT 604285 4557289 5.00E-88 1.00E-88 2.00E-16 CT13067 T14D7.1 YFL030W
1º Hypomagnesemia-CLDN16 603959 5729970 4.30E+00 8.30E-01 1.00E+00      
Hypophosphatasia-ALPL 171760 130749 1.00E-105 2.50E+00 9.00E-35 CT24348   YDR482C
Nephronophthisis 1-NPHP1 256100 4557805 2.00E-06 7.00E-20 3.00E-04   M28.7  
Polycystic Kidney 1-PKD1 601313 904223 4.00E-13 1.00E-13 3.70E+00   ZK945.9  
Polycystic Kidney 2-PKD2 173910 1373169 1.00E-66 5.00E-76 5.40E-02 CT20227 Y73F8A.B  
Pseudohypoaldoster.-NR3C2 600983 3342402 2.00E-37 7.00E-24 5.10E+00   F11C1.6  
Renal Tubul. Acidosis-ATP6B1 192132 4093211 1.00E-138 0.00E+00 0.00E+00 CT38368 F20B6.2 YBR127C
Vitamin D Resis. Rickets-PHEX 307800 1834505 1.00E-124 1.00E-125 0.27 CT18487 F18A12.8  
Williams-Beuren-ELN 130160 5881413 1.00E+00 1.00E+00 1.00E+00      
                 
Hematological                
Chediak-Higashi-CHS1 214500 4502839 1.00E-141 1.00E-107 3.00E-75 CT36933 VT23B5.2 YCR032W
Diamond-Blackfan Anem.-RPS19 603474 730640 2.00E-48 2.00E-38 1.00E-35 CT14524 T05F1.3 YOL121C
Essen.Thrombocythemia-THPO 600044 4507493 5.70E-01 7.20E-01 9.10E-02      
G6PD Deficiency.-G6PD 305900 4503845 0.00E+00 1.00E-176 1.00E-125 CT33838 B0035.5 YNL241C
HPLH2-PRF1 170280 4826942 1.90E-01 2.00E-04 1.70E+00      
Hemophilia A-F8C 306700 4503647 2.00E-17 5.00E-15 1.00E-01   C25F6.4  
Hemophilia B-F9 306900 4503649 3.00E-41 7.00E-40 1.00E+00      
Hered. Spherocytosis-ANK1 182900 4502089 0.00E+00 0.00E+00 1.00E-16 CT13989 B0350.2C YGR233C
Megaloblas. Anemia-SLC19A2 249270 5514679 6.00E-70 1.00E-61 2.30E-01 CT20470 C06H2.4  
Myeloperoxidase Defic.-MPO 254600 4557759 1.00E-137 1.00E-134 7.00E+00 CT1239 ZK994.3  
Osler-Rendu-Weber-ENG 131195 3201589 1.70E-01 8.30E-01 2.10E+00      
a-Thalassemia-HBA1 141800 4504345 2.00E+00 1.50E+00 4.80E+00      
b-Thalassemia-HBB 141900 4504349 2.20E+00 2.20E+00 4.00E+00      
d-Thalassemia-HBD 142000 4504351 7.50E-01 1.20E+00 1.80E+00      
e-Thalassemia-HBE 142100 4885393 1.50E-01 2.40E-01 5.00E-03      
Thrombophilia-PLG 173350 4505881 9.00E-39 2.00E-40 1.00E+00 CT33220    
Von Willebrand-VWF 193400 4507907 1.00E-161 3.00E-12 1.10E+00   M142.2  
Wiskott-Aldrich-WAS 301000 1722836 2.00E-45 7.00E-06 2.00E-10 CT3925   YOR181W
                 
                 
Immune                
Bare Lymphocyte-ABCB3 170261 106985 5.00E-72 1.00E-116 1.00E-73 CT5524 ZK484.2 YPL270W
Bare Lymphocyte-RFX5 601863 4557843 4.00E-26 1.00E-10 3.00E-11 CT27410 F33H1.1 YLR176C
Bare Lymphocyte-RFX5AP 601861 4506501 1.00E+00 1.00E+00 1.00E+00      
Bare Lymphocyte-MHC2TA 600005 4557749 2.00E-02 9.00E-03 4.00E-03      
Bruton Agammaglobulin.-BTK 300300 4557377 1.00E-136 7.00E-85 9.00E-22 CT24151 M79.1B YKL166C
Chronic Granulom.-NCF1 233700 189051 5.00E-11 1.00E-09 2.00E-04   Y116A8C.36  
Chronic Granulom.-CYBB 306400 225909 5.00E-36 4.00E-34 6.00E-06 CT10494 F53G12.2  
Immunodeficiency-DNA Ligase 1 126391 4557719 0.00E+00 1.00E-167 1.00E-146 CT17704 C29A12.3 YDL164C
Immunodeficiency-CD3G 186740 4557429 3.00E-14 2.00E-65 6.00E-24   C26G2.1 YJR161C
SCID-IL2RG 308380 4557882 6.10E-01 1.00E+00 3.20E+00      
SCID-IL7R 146661 4504679 5.80E-01 3.30E-01 4.10E+00      
SCID-JAK3 600173 4557681 2.00E-50 2.00E-36 6.00E-22 CT4219 F49B2.5 YAR019C
SCID-RAG1 179615 4557841 3.00E-09 5.00E-04 2.00E-03      
SCID-RAG2 179616 2498830 3.50E-02 1.00E-01 2.20E-02      
SCID-ZAP70 176947 1177044 4.00E-58 5.00E-56 9.00E-22 CT13380 M79.1C YDR523C
T-Cell Immunodefic.-CD3E 186830 4502671 9.00E-03 6.70E-01 1.90E-01      
X-Linked Lymphoprol.-SH2D1A 308240 6094278 9.00E-11 1.00E-09 1.00E+00   M79.1B  
                 
Metabolic                
CPT2 Deficiency-CPT2 600650 4503023 1.00E-158 1.00E-151 9.00E-69 CT1795 R07H5.2 YAR035W
1º Carnitine Defic.-SLC22A5 603377 3242598 7.00E-90 5.00E-78 1.00E-10 CT19810 F52F12.1 YGL104C
Citrullinemia, Type I-ASS 603470 114287 2.00E-43 5.00E-01 1.00E-112 CT2879   YOL058W
Cystinuria, Type 1-SLC3A1 104614 306442 1.00E-102 3.00E-32 2.00E-52 CT6492 F26D10.9 YJL221C
Hypercalcemia-CASR 601199 1168781 2.00E-94 1.00E-77 2.00E+00   ZC506.4  
Galactokinase-GALK1 604313 4503895 9.00E-15 2.00E-14 3.00E-10 CT16885 M01D7.4 YBR020W
Gaucher-GBA 230800 121283 2.00E-75 1.00E-112 1.30E-02 CT28913 F11E6.1  
Hemochromatosis-HFE 235200 4504377 1.70E+00 1.30E+00 1.00E+00      
Lesch-Nyhan-HPRT1 308000 4504483 8.30E+00 1.00E-50 2.00E-01   Y105E8B.J  
Liddle-SCNN1G 600761 4506821 2.00E-09 4.00E-35 5.30E-01 CT24238 R13A1.4  
Liddle-SCNN1B 600760 4506817 6.00E-10 2.00E-39 1.80E-01 CT15439 R13A1.4  
Menkes-ATP7A 300011 4502321 0.00E+00 0.00E+00 1.00E-139 CT5824 Y76A2A.2 YDR270W
Niemann-Pick-NPC1 257220 2276463 0.00E+00 1.00E-147 1.00E-159 CT5792 F02E8.6 YPL006W
SCID-ADA 102700 4557249 3.00E-14 2.00E-65 6.00E-24 CT32131 C06G3.5 YNL141W
Trimethylaminuria-FMO3 136132 6325467 3.00E-27 1.00E-109 4.00E-20 CT10128 Y39A1A.19 YHR176W
Variegate Porphyria-PPOX 600923 4506001 6.00E-80 6.80E-02 4.00E-20 CT18194   YER014W
Wernicke-Korsakoff-TKT 277730 4507521 0.00E+00 0.00E+00 4.00E-28 CT24118 F01G10.1 YBR117C
                 
Other                
a-1-Antitrypsin Deficency-PI 107400 4505793 3.00E-39 2.00E-37 4.80E+00 CT11129 C05E4.1  
Alveolar Proteinosis-SFTPB 178640 4506905 6.00E-11 4.10E+00 1.00E+00      
Corneal Dystrophy-TGFBI 601692 339568 6.00E-29 8.00E-10 1.00E-04 CT39319 F26E4.7  
Cystic Fibrosis-ABCC7 602421 1705762 1.00E-102 1.00E-144 9.00E-76 CT14766 F57C12.4 YDR135C
Cystinosis-CTNS 219800 3036840 6.00E-75 2.00E-40 2.00E-18 CT38040   YCR075C
Darier-White-SERCA 108740 114312 0.00E+00 0.00E+00 1.00E-117 CT12479 K11D9.2A YGL167C
Downreg. in Adenoma-DRA 126650 729367 9.00E-59 1.00E-72 1.00E-30   K12G11.2 YLR092W
Ehlers-Danlos IV-COL3A1 120180 930045 2.00E-06 1.00E-06 1.00E+00   F54D8.1  
Fam. Mediterr. Fever-MEFV 249100 2407316 9.00E-05 1.00E-03 5.60E-02      
Finnish Amyloidosis-GSN 137350 121116 1.00E-129 2.00E-59 2.50E+00 CT1647 B0523.5  
Glycerol Kinase Defic.-GK 307030 348167 1.00E-142 1.00E-143 3.00E-95 CT1673 R11F4.1 YHL032C
Hereditary Pancreatitis-PRSS1 276000 1616766 1.00E-09 5.00E-03 3.40E+00 CT29400    
Hermansky-Pudlak-HPS 203300 4504485 8.00E-28 9.00E-01 2.20E+00 CT31995    
Hyperexplexia-GLRA2 138491 31851 2.00E-85 1.00E-76 6.90E+00 CT23049 T10G3.7  
Juvenile Glaucoma-GLC1A 231500 2104789 5.00E-29 2.00E-23 4.00E-07 CT21241 F11C3.2 YOR216C
Keratoderma-KRT9 144200 453155 6.00E-22 5.00E-26 7.00E-09   W10G6.3 YDL058W
Marfans-FBN1 134797 544279 1.00E-171 1.00E-104 5.70E-02 CT35799 Y64G10A.7  
Mcleod-XK 314850 4883433 7.50E-01 8.00E-05 2.70E-01      
Monilethrix-KRTHB 602153 4504931 3.00E-28 2.00E-31 2.00E-06   F38B2.1  
Monilethrix-KRTHB6 601928 2695879 4.00E-28 1.00E-31 2.00E-06   F38B2.1  
Osteogenesis Imperf.-COL1A1 120150 2144803 7.00E-11 9.00E-11 1.00E+00   W03G11.1  
Spondyloepip.Dysp .-COL2A1 120140 1070602 5.00E-18 9.00E-20 1.00E+00   F01G12.5A  
Vohwinkel-LOR 152445 4557725 1.00E+00 1.00E+00 1.00E+00      
Wolfram-WFS1 222300 5174749 2.00E-31 1.20E+00 1.00E+00 CT15800 F29D11.2  

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