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What automation can do for you: The benefits and pitfalls of automating your microscopy research

This webinar is brought to you by the Science/AAAS Custom Publishing Office

What automation can do for you: The benefits and pitfalls of automating your microscopy research

01 February 2017

12:00 p.m. ET

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Speakers

In the life sciences, experimental reproducibility and repeatability are essential for ensuring that the results obtained are real and trustworthy. This often involves running an experiment multiple times under identical conditions. When repeating experiments, variation introduced through human error, environmental changes, or technical fluctuations can negatively impact the data and cause the generation of spurious results. For example, when imaging cells, slight shifts in temperature, CO2 levels, or light conditions can dramatically affect the data. The automation of methodologies, in concert with the ability to run multiple experiments in parallel, can go a long way to solving this problem. During this webinar we will provide examples of how automation of imaging methods can save time and money, making your work easier and more efficient and enabling the generation of more reliable data.

During the webinar, the speakers will:

• Summarize how automated microscopy and image analysis can be used in cell-based assays and the drug-discovery process
• Discuss the application of high-throughput automated microscopy for live imaging of diverse species
• Outline how expansion microscopy is enabling systematic, multiplexed molecular mapping of cells and tissues.

This webinar will last for approximately 60 minutes

Speaker bios

Meltsje de Hoop, Ph.D.

Sanofi S.A.
Frankfurt, Germany

Dr. de Hoop completed her doctoral degree at the University of Groningen in the Netherlands in collaboration with Salk Institute Biotechnology Industrial Associates Inc. in La Jolla, California, before moving to the European Molecular Biology Laboratory in Heidelberg, Germany, where she undertook her postdoctoral training. In 1997, she joined Sanofi S.A. (previously Sanofi-Aventis) and is currently a laboratory head working in its drug discovery space. Dr. de Hoop develops cell-based assays for high-throughput screening of small molecules, peptides, and proteins for therapeutic activity, as well as low- and medium-throughput assays using automated microscopy.

Seth Donoughe, Ph.D. Candidate

Harvard University
Cambridge, MA

Mr. Donoughe completed his undergraduate studies in biology at Swarthmore College and then studied the genetic basis of planar cell polarity in the laboratory of Dr. Steve DiNardo at the University of Pennsylvania’s Perelman School of Medicine. He is currently a Ph.D. student in the laboratory of Dr. Cassandra Extavour in the Department of Organismic and Evolutionary Biology at Harvard University. His research interests center on the evolution, developmental genetics, biomechanics, and cell biology of invertebrates. Mr. Donoughe uses high-throughput live-imaging microscopy and quantitative modeling to understand morphogenesis in diverse insect embryos.

Ed Boyden, Ph.D.

Massachusetts Institute of Technology
Cambridge, MA

Dr. Boyden is professor of biological engineering and brain and cognitive sciences at the Massachusetts Institute of Technology (MIT) Media Lab and the MIT McGovern Institute for Brain Research. He received three degrees—two in electrical engineering and computer science, and one in physics—from MIT before completing his Ph.D. in neuroscience at Stanford University. Dr. Boyden leads the Synthetic Neurobiology Group, which develops tools for analyzing and repairing complex biological systems such as the brain, and applies these tools systematically to reveal ground-truth principles of biological function as well as to repair these systems. These technologies include expansion microscopy, which enables complex biological systems to be imaged with nanoscale precision, and optogenetic tools, which facilitate the activation and silencing of neural activity with light. He also codirects the MIT Center for Neurobiological Engineering, which aims to develop new tools to accelerate neuroscience progress. Dr. Boyden has received numerous prestigious awards, including the Breakthrough Prize in Life Sciences (2016), and has contributed to over 300 peer-reviewed papers, current or pending patents, and articles.

Sean Sanders, Ph.D.

Science/AAAS
Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently Dr. Sanders is the Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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