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Validating Complex Biology: How Arrays Can Complement Your Next-Gen Data

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Validating Complex Biology:  How Arrays Can Complement Your Next-Gen Data

Recorded 05 December 2012

Speakers

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Researchers need to be aware of the pitfalls that can lurk in data-intensive studies and that errors or misinterpretations in data analysis can lead them to erroneous biological conclusions. Today the research community has a variety of high throughput methods available and the results of one method can be readily validated using a different, orthogonal technology, such as the use of real-time PCR experiments to validate microarray results. With the emergence of sequencing-based studies that require scientists to identify rare genetic phenomena using relatively new methods, it is increasingly important to complement these studies with an orthogonal and proven technology such as microarrays.

During the webinar, the panelists will:

  • Discuss the importance and relevance of validating data using orthogonal methods
  • Provide best-practice advice for validating next generation sequencing results using microarray technology
  • Answer your questions live on air!

For more information on products/technologies related to this webinar, go to: www.affymetrix.com/downtoascience

Speaker bios

Rafael Irizarry, Ph.D.

Johns Hopkins Bloomberg School of Public Health
Baltimore, MD

Dr. Irizarry received his Bachelor’s in mathematics from the University of Puerto Rico and went on to receive a Ph.D. in statistics from the University of California, Berkeley. He joined the faculty of the Department of Biostatistics in the Bloomberg School of Public Health in 1998 and was promoted to full professor in 2007. For the past 10 years, Dr. Irizarry’s work has focused on genomics and computational biology problems. In particular, he has worked on the analysis and preprocessing of microarray, next generation sequencing, and genomic data in general. He is currently interested in leveraging his knowledge in translational work, such as developing diagnostic tools and discovering biomarkers. Dr. Irizarry also develops open source software implementing his statistical methodology. He is one of the leaders and founders of the Bioconductor Project, an open source and open development software project for the analysis of genomic data. Dr. Irizarry won the Presidents' Award and Mortimer Spiegelman Award in 2009 and the 2001 American Statistical Association Noether Young Scholar Award.

Don A. Baldwin, Ph.D.

Pathonomics LLC
Philadelphia, PA

Dr. Baldwin completed his Ph.D. at the University of Florida in Gainesville in microbiology and cell science, followed by postdoctoral training at Pioneer Hi-Bred International in Johnston, Iowa. He then moved to the University of Pennsylvania where he created and directed a microarray resource facility in the Perelman School of Medicine, leading the core’s development into the Molecular Profiling Facility for array, deep sequencing, and bioinformatics services. Dr. Baldwin was co-founder of Pathonomics LLC, which provides tools and services for profiling complex collections of microorganisms found in a variety of clinical and environmental specimen types.  He now serves as chief scientific officer at Pathonomics. Dr. Baldwin is an associate editor of Frontiers in Neurogenomics and editorial board member for Journal of Biomolecular Techniques.

Sean Sanders, Ph.D.

Science/AAAS
Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently Dr. Sanders is the Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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