Some of the major challenges in research today include understanding disease progression and classifying diseases based on molecular markers. Obtaining quantitative information about gene-expression changes within cells in their native environment is laborious and challenging: Immunohistochemistry and in situ hybridization remain low throughput, nonquantitative technologies, while bulk sequencing does not reveal spatial information. However, methods that combine traditional histology with transcriptome data are already available or under development—some can capture the full transcriptome in a standard-size tissue section, while others focus on subsets of mRNAs with single-cell resolution. A new technology termed “spatial transcriptomics” uses spatially barcoded, complementary DNA primers for full-transcriptome capture on tissue sections, and can be applied alone or in combination with single-cell technologies. The method is easy to perform and is used by a rapidly growing number of academic institutions and pharmaceutical companies.
This webinar will explore:
- How spatial transcriptomics in individual tissue sections provides access to full-transcriptome data in 2D or 3D
- Practical application and performance of the method in basic and medical research
- How the technology can be used in combination with single-cell sequencing.
Viewers can ask questions during the live broadcast!
To learn more about products or technologies related to this webinar, go to https://spatialtranscriptomics.com/.
This webinar will last for approximately 60 minutes.