Tumor metastasis is a multistep process that includes stimulation of angiogenesis, intravasation of tumor cells into blood or lymphatic vessels, and subsequent engraftment and extravasation to peripheral tissues where secondary tumors are seeded. It is known that metastatic progression is driven by mutational and epigenetic changes in tumor cells, but more recent efforts have focused on the evolving interplay between the tumor cell and the tumor microenvironment (TME) during invasion and transition from micrometastasis to macrometastasis. Whether the tumor cell or the subverted vascular niche/premetastatic niche is the driver of TME evolution remains the subject of debate. This webinar examines the role of tumor-secreted factors, including exosomes and tumor vascular niche–derived protumorigenic factors in tumor–environment interactions, and their implications for development of therapeutic interventions to arrest metastasis.
During the webinar, the viewers will:
- Hear about the importance of the TME for tumor progression and metastasis
- Be introduced to the concept of the vascular niche/premetastatic niche and its role in metastasis
- Learn how angiocrine-derived factors dictate tumor stemness
- Be able to put their questions to the panel during the live broadcast!
This webinar will last for approximately 60 minutes