Protein Dynamics

Proteins in Motion

Valda J. Vinson
Science 10 April 2009: 197.
Summary »|   PDF »|  

Perspective

Trapping Moving Targets with Small Molecules

Gregory M. Lee and Charles S. Craik
Science 10 April 2009: 213-215.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reviews

Sending Signals Dynamically

Robert G. Smock and Lila M. Gierasch
Science 10 April 2009: 198-203.
Abstract »|   Full Text »|   PDF »|  

Protein Dynamism and Evolvability

Nobuhiko Tokuriki and Dan S. Tawfik
Science 10 April 2009: 203-207.
Abstract »|   Full Text »|   PDF »|  

Multiscale Modeling of Form and Function

Adam J. Engler, Patrick O. Humbert, Bernhard Wehrle-Haller, and Valerie M. Weaver
Science 10 April 2009: 208-212.
Abstract »|   Full Text »|   PDF »|  

This Week in Science

Editor summaries of this week's papers.
Science 10 April 2009: 143.
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Editorial:
Helping the President

Neal Lane
Science 10 April 2009: 147.
Summary »|   Full Text »|   PDF »|  

Editors' Choice

Highlights of the recent literature.
Science 10 April 2009: 149.
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Quarterly Author Index

Science 10 April 2009: 280.
Summary »|  

Science Podcast

Science 10 April 2009: 280.
The 10 April 2009 show includes animal flight dynamics, rebuilding America's ocean ecosystems, genetic screening in newborns, and more. Summary »|   Full Text »|   Transcript »|  

NEW PRODUCTS

Science 10 April 2009: 280.
Summary »|   PDF »|  

News of the Week

RECESSION FALLOUT: Harvard's Financial Crunch Raises Tensions Among Biology Programs

Eliot Marshall
Science 10 April 2009: 157-158.
Budget cuts at Harvard University have raised tensions with city politicians and exposed some fault lines within the faculty over an emphasis on stem cell medicine and a push for more collaborative, interdisciplinary work. Summary »|   Full Text »|   PDF »|  

COSMOLOGY: Unlucky CLOVER: U.K. Halts Unfinished Telescope Project

Adrian Cho
Science 10 April 2009: 158.
The United Kingdom has canceled a cosmology experiment that would have been Europe's prime contender in the race to trace the gravitational waves that rippled through the infant universe. Summary »|   Full Text »|   PDF »|  

NEWSMAKER INTERVIEW: Arne Duncan Hopes a Team Approach Will Improve U.S. Schools

Jeffrey Mervis
Science 10 April 2009: 159.
During a recent interview with Science in his Washington, D.C., office, Education Secretary Arne Duncan discussed science education standards, the federal government's role in education, and how to make teachers more effective. Summary »|   Full Text »|   PDF »|   Extended Interview »|  

LUNAR AND PLANETARY SCIENCE CONFERENCE: A Primal Crust Found on the Moon, While Mercury's Proves Elusive

Richard A. Kerr
Science 10 April 2009: 161.
Researchers from two ongoing missions to the moon reported at the Lunar and Planetary Science Conference that they now have the final, direct proof of the "lunar magma ocean" hypothesis of the formation of the moon's bright highlands. Summary »|   Full Text »|   PDF »|  

LUNAR AND PLANETARY SCIENCE CONFERENCE: Water Everywhere on Mars, But Is Any of It Ever Liquid?

Richard A. Kerr
Science 10 April 2009: 161.
At the Lunar and Planetary Science Conference, teammates on the Phoenix mission to Mars reported Phoenix observations buttressed with thermodynamic arguments that suggest that briny liquid water exists at the Phoenix site. Not everyone agrees. Summary »|   Full Text »|   PDF »|  

EVOLUTIONARY MEDICINE: Darwin Applies to Medical School

Elizabeth Pennisi
Science 10 April 2009: 162-163.
At a meeting last week on Evolution in Health and Medicine, researchers reported headway in understanding drug resistance through the lens of evolution and progress in linking past evolutionary adaptations with current health problems. Summary »|   Full Text »|   PDF »|  

EVOLUTIONARY MEDICINE: Two Sides of the Same Coin?

Constance Holden
Science 10 April 2009: 162-163.
An evolutionary geneticist proposed at a meeting last week on Evolution in Health and Medicine that both schizophrenia and autism are disorders of the "social brain"--but at opposite ends of the same spectrum. Summary »|   Full Text »|   PDF »|  

SCIENCENOW.ORG: From Science's Online Daily News Site

Science 10 April 2009: 163.
Highlights from Science's online daily news site, ScienceNOW, this week include viruses that can make rechargeable batteries, the oldest stone blades, and the first global look at human sex ratios. Summary »|   Full Text »|   PDF »|  

DRUG DEVELOPMENT: New Way to Target Hormone Receptor Thwarts Prostate Cancer

Jocelyn Kaiser
Science 10 April 2009: 165.
Researchers report online in Science this week that they've developed a compound that in mice shrank implanted human prostate tumors untreatable with current drugs and that it showed signs of arresting tumor growth in men with similarly drug-resistant cancer. Summary »|   Full Text »|   PDF »|  

SCIENCEINSIDER: From the Science Policy Blog

Science 10 April 2009: 165.
Science's policy blog, ScienceInsider, reported this week on the latest blow to gene patents, a rally in support of research using animals, gender imbalance in a new batch of early-career awards, and other stories. Summary »|   Full Text »|   PDF »|  

Random Samples

Science 10 April 2009: 155.
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News Focus

NEWBORN BLOOD COLLECTIONS: Science Gold Mine, Ethical Minefield

Jennifer Couzin-Frankel
Science 10 April 2009: 166-168.
Health agencies launched a system 40 years ago to identify babies at risk. Now there are millions of blood samples in files that researchers want to access, raising public concern. Summary »|   Full Text »|   PDF »|   Podcast Interview »|  

PALEONTOLOGY: The 'Tamba Dragon' Has Japanese Dinosaur Hunters All Fired Up

Dennis Normile
Science 10 April 2009: 169.
A serendipitous sauropod specimen could shed light on the evolution of our planet's largest land animals. Summary »|   Full Text »|   PDF »|  

GLOBAL FISHERIES: Détente in the Fisheries War

Erik Stokstad
Science 10 April 2009: 170-171.
After a controversial projection that wild-caught fish will disappear, top researchers buried the hatchet to examine the status of fisheries--and what to do about it. Summary »|   Full Text »|   PDF »|  

ENERGY: Renewables Test IQ of the Grid

Dan Charles
Science 10 April 2009: 172-175.
Everybody agrees that tomorrow's electrical grid must incorporate wind and solar power seamlessly. But solving the reliability issue won't be easy. Summary »|   Full Text »|   PDF »|  

ENERGY: Students Energized by Power Engineering

Dan Charles
Science 10 April 2009: 175.
The study of electrical power generation and transmission has long occupied the dusty back corners of U.S. academia. But with energy back in the headlines, students are returning to the field. Summary »|   Full Text »|   PDF »|  

Letters

 Advancing Human Rights Through Science

Jeffrey H. Toney
Science 10 April 2009: 176.
Full Text »|   PDF »|  

 Tracing Fossil History

Ronald Mcdowell;, Stefan Bengtson, and Birger Rasmussen
Science 10 April 2009: 176-177.
Full Text »|   PDF »|  

 Risks of Extreme Heat and Unpredictability

Neal Hockley, James M. Gibbons, Gareth Edwards-Jones;, David S. Battisti, and Rosamond L. Naylor
Science 10 April 2009: 177-179.
Full Text »|   PDF »|  

 LIFE IN SCIENCE: Seeds of Doubt

Peter H. Klopfer
Science 10 April 2009: 177.
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Books et al.

DEVELOPMENT: Learning from Errors

Manfred D. Laubichler
Science 10 April 2009: 181-182.
Blumberg presents examples of aberrant individuals as an underappreciated perspective on developmental and evolutionary processes. Summary »|   Full Text »|   PDF »|  

ENTOMOLOGY: Social Selection

Nigel R. Franks
Science 10 April 2009: 182.
This accessible introduction to the ecology, behavior, and evolution of ants also considers ways that findings from studies of ants apply to such topics as computer programming and swarm intelligence. Summary »|   Full Text »|   PDF »|  

Books Received

Science 10 April 2009: 182.
Summary »|  

Policy Forum

OCEANS: Legal Bedrock for Rebuilding America's Ocean Ecosystems

Mary Turnipseed, Larry B. Crowder, Raphael D. Sagarin, and Stephen E. Roady
Science 10 April 2009: 183-184.
The public trust doctrine would provide a powerful framework for restructuring the way we manage U.S. oceans. Summary »|   Full Text »|   PDF »|   Supporting Online Material »|  Podcast Interview »|  

Perspectives

APPLIED PHYSICS: Electrode-Cellular Interface

G. G. Wallace, S. E. Moulton, and G. M. Clark
Science 10 April 2009: 185-186.
Electrode materials that facilitate interaction with living cells are crucial for the development of next-generation bionic devices. Summary »|   Full Text »|   PDF »|  

CHEMISTRY: Total Chemical Synthesis Peers into the Biosynthetic Black Box

Scott J. Miller
Science 10 April 2009: 186-187.
Key steps in a natural product synthesis route may relate to nature's strategies and catalysts. Summary »|   Full Text »|   PDF »|  

GENETICS: Leishmania Exploit Sex

Michael A. Miles, Matthew Yeo, and Isabel L. Mauricio
Science 10 April 2009: 187-189.
Leishmania are the last of the three major groups of trypanosomatid parasites to give up their secret--a healthy capacity for genetic exchange. Summary »|   Full Text »|   PDF »|  

EVOLUTION: Symmetry in Turns

Bret W. Tobalske
Science 10 April 2009: 190-191.
A model explains how animals maneuver during hovering and slow flight. Summary »|   Full Text »|   PDF »|  

GENOMICS: Green Evolution, Green Revolution

John M. Archibald
Science 10 April 2009: 191-192.
The genomes of two species of green algae provide clues to how green plants evolved. Summary »|   Full Text »|   PDF »|  

CANCER: Puzzling Patterns of Predisposition

Patrick J. Pollard and Peter J. Ratcliffe
Science 10 April 2009: 192-194.
Mutations in a gene that encodes a metabolic enzyme have been linked to certain brain tumors, but is the gene a tumor suppressor or an oncogene? Summary »|   Full Text »|   PDF »|  

APPLIED PHYSICS: Laser Beams Take a Curve

Jérôme Kasparian and Jean-Pierre Wolf
Science 10 April 2009: 194-195.
Complex energy flows within laser beams can cause them to curve as they travel. Summary »|   Full Text »|   PDF »|  

Brevia

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

Siân Jones, Ralph H. Hruban, Mihoko Kamiyama, Michael Borges, Xiaosong Zhang, D. Williams Parsons, Jimmy Cheng-Ho Lin, Emily Palmisano, Kieran Brune, Elizabeth M. Jaffee, Christine A. Iacobuzio-Donahue, Anirban Maitra, Giovanni Parmigiani, Scott E Kern, Victor E. Velculescu, Kenneth W. Kinzler, Bert Vogelstein, James R. Eshleman, Michael Goggins, and Alison P. Klein
Science 10 April 2009: 217.
Published online 5 March 2009 [DOI: 10.1126/science.1171202] (in Science Express Brevia)
Mutations in a gene previously implicated in breast cancer are a contributing factor in hereditary pancreatic cancer. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Article

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

Nicholas T. Ingolia, Sina Ghaemmaghami, John R. S. Newman, and Jonathan S. Weissman
Science 10 April 2009: 218-223.
Published online 12 February 2009 [DOI: 10.1126/science.1168978] (in Science Express Research Articles)
Profiling the position of ribosomes on messenger RNA allows rapid, high-precision investigation of cellular protein translation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Elastic Shear Anisotropy of Ferropericlase in Earth's Lower Mantle

Hauke Marquardt, Sergio Speziale, Hans J. Reichmann, Daniel J. Frost, Frank R. Schilling, and Edward J. Garnero
Science 10 April 2009: 224-226.
A minor phase of the deep mantle causes marked differences in seismic travel times in different directions. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Great Earthquake Rupture Across a Rapidly Evolving Three-Plate Boundary

Kevin P. Furlong, Thorne Lay, and Charles J. Ammon
Science 10 April 2009: 226-229.
This event revealed plate dynamics in the Solomon Islands and showed that subduction of young crust can produce great quakes. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Curved Plasma Channel Generation Using Ultraintense Airy Beams

Pavel Polynkin, Miroslav Kolesik, Jerome V. Moloney, Georgios A. Siviloglou, and Demetrios N. Christodoulides
Science 10 April 2009: 229-232.
Propagating intense structured laser beams through air creates self-focused "light bullets" that take a curved trajectory. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Solar Power Wires Based on Organic Photovoltaic Materials

Michael R. Lee, Robert D. Eckert, Karen Forberich, Gilles Dennler, Christoph J. Brabec, and Russell A. Gaudiana
Science 10 April 2009: 232-235.
Published online 12 March 2009 [DOI: 10.1126/science.1168539] (in Science Express Reports)
A transparent polymer coating allows optics to compensate for the shadowing effects of a metal wire electrode. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Running Droplets of Gallium from Evaporation of Gallium Arsenide

J. Tersoff, D. E. Jesson, and W. X. Tang
Science 10 April 2009: 236-238.
Oscillation of gallium droplets is driven by a disequilibrium between the droplets and the gallium arsenide surface. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Total Synthesis of (+)-11,11'-Dideoxyverticillin A

Justin Kim, James A. Ashenhurst, and Mohammad Movassaghi
Science 10 April 2009: 238-241.
The key step in the synthesis of this complex fungal metabolite replaces four introduced hydroxyl groups with thiols. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Pulsatile Stimulation Determines Timing and Specificity of NF-B-Dependent Transcription

Louise Ashall, Caroline A. Horton, David E. Nelson, Pawel Paszek, Claire V. Harper, Kate Sillitoe, Sheila Ryan, David G. Spiller, John F. Unitt, David S. Broomhead, Douglas B. Kell, David A. Rand, Violaine Sée, and Michael R. H. White
Science 10 April 2009: 242-246.
The frequency of pulses of cytokine simulation of a cell can determine the spectrum of genes whose transcription is regulated. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

Damian C. Ekiert, Gira Bhabha, Marc-André Elsliger, Robert H. E. Friesen, Mandy Jongeneelen, Mark Throsby, Jaap Goudsmit, and Ian A. Wilson
Science 10 April 2009: 246-251.
Published online 26 February 2009 [DOI: 10.1126/science.1171491] (in Science Express Reports)
A broadly neutralizing antibody binds the hemagglutinin stalk of pathogenic influenza viruses to block membrane fusion. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Wingbeat Time and the Scaling of Passive Rotational Damping in Flapping Flight

Tyson L. Hedrick, Bo Cheng, and Xinyan Deng
Science 10 April 2009: 252-255.
Morphology and flapping motion are combined in a model that predicts turn dynamics for flying animals ranging in size from fruit flies to cockatoos. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  Podcast Interview »|  

Coding-Sequence Determinants of Gene Expression in Escherichia coli

Grzegorz Kudla, Andrew W. Murray, David Tollervey, and Joshua B. Plotkin
Science 10 April 2009: 255-258.
RNA structure, rather than optimal codon usage, determines translation efficiency in Escherichia coli. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Leucine-Rich Repeat Protein Complex Activates Mosquito Complement in Defense Against Plasmodium Parasites

Michael Povelones, Robert M. Waterhouse, Fotis C. Kafatos, and George K. Christophides
Science 10 April 2009: 258-261.
Published online 5 March 2009 [DOI: 10.1126/science.1171400] (in Science Express Reports)
A family of molecules, apparently unique to mosquitoes, binds to invading parasites and initiates innate immune responses. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1

Shimin Zhao, Yan Lin, Wei Xu, Wenqing Jiang, Zhengyu Zha, Pu Wang, Wei Yu, Zhiqiang Li, Lingling Gong, Yingjie Peng, Jianping Ding, Qunying Lei, Kun-Liang Guan, and Yue Xiong
Science 10 April 2009: 261-265.
Mutations in isocitrate dehydrogenase-1 compromise enzyme function and activate a signaling pathway that helps brain tumors grow when oxygen is limited. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Demonstration of Genetic Exchange During Cyclical Development of Leishmania in the Sand Fly Vector

Natalia S. Akopyants, Nicola Kimblin, Nagila Secundino, Rachel Patrick, Nathan Peters, Phillip Lawyer, Deborah E. Dobson, Stephen M. Beverley, and David L. Sacks
Science 10 April 2009: 265-268.
Diversity among Leishmania parasites is not just a product of divergent mutation but also of genetic exchange. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Green Evolution and Dynamic Adaptations Revealed by Genomes of the Marine Picoeukaryotes Micromonas

Alexandra Z. Worden, Jae-Hyeok Lee, Thomas Mock, Pierre Rouzé, Melinda P. Simmons, Andrea L. Aerts, Andrew E. Allen, Marie L. Cuvelier, Evelyne Derelle, Meredith V. Everett, Elodie Foulon, Jane Grimwood, Heidrun Gundlach, Bernard Henrissat, Carolyn Napoli, Sarah M. McDonald, Micaela S. Parker, Stephane Rombauts, Aasf Salamov, Peter Von Dassow, Jonathan H. Badger, Pedro M. Coutinho, Elif Demir, Inna Dubchak, Chelle Gentemann, Wenche Eikrem, Jill E. Gready, Uwe John, William Lanier, Erika A. Lindquist, Susan Lucas, Klaus F. X. Mayer, Herve Moreau, Fabrice Not, Robert Otillar, Olivier Panaud, Jasmyn Pangilinan, Ian Paulsen, Benoit Piegu, Aaron Poliakov, Steven Robbens, Jeremy Schmutz, Eve Toulza, Tania Wyss, Alexander Zelensky, Kemin Zhou, E. Virginia Armbrust, Debashish Bhattacharya, Ursula W. Goodenough, Yves Van de Peer, and Igor V. Grigoriev
Science 10 April 2009: 268-272.
An anciently derived clade of photosynthetic picoeukaryote, ubiquitous in the world's oceans, possesses surprising genetic diversity. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|