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COVER Wealthy nations now devote billions of dollars each year to helping low- and middle-income countries confront HIV/AIDS epidemics. Investment in biomedical research has also shot up. What has come of this flood of money? And will there be enough in the future to meet increasing demands? See the special section beginning on page 511. Image: Kelly Krause/Science

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Science. ISSN 0036-8075 (print), 1095-9203 (online)