Single Molecules

Lights, Camera, Action

Valda Vinson and Gilbert Chin
Science 25 May 2007: 1143.
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Reviews

Single-Molecule Experiments in Vitro and in Silico

Marcos Sotomayor and Klaus Schulten
Science 25 May 2007: 1144-1148.
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Forces and Bond Dynamics in Cell Adhesion

Evan A. Evans and David A. Calderwood
Science 25 May 2007: 1148-1153.
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Far-Field Optical Nanoscopy

Stefan W. Hell
Science 25 May 2007: 1153-1158.
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This Week in Science

Editor summaries of this week's papers.
Science 25 May 2007: 1093.
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Editorial:
New Life for Systematics

Stephen D. Hopper
Science 25 May 2007: 1097.
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Editors' Choice

Highlights of the recent literature.
Science 25 May 2007: 1099.
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NEW PRODUCTS

Science 25 May 2007: 1217.
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News of the Week

AVIAN INFLUENZA: Indonesia Earns Flu Accord at World Health Assembly

Martin Enserink
Science 25 May 2007: 1108.
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INFECTIOUS DISEASE: Resurgence of Yellow Fever in Africa Prompts a Counterattack

Leslie Roberts
Science 25 May 2007: 1109.
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GEOCHEMISTRY: Isotopes Suggest Solar System Formed in a Rough Neighborhood

Richard A. Kerr
Science 25 May 2007: 1111.
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U.S POLITICS: Nobelist Eyes Minnesota Senate Seat

Eliot Marshall
Science 25 May 2007: 1112.
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NONPROLIFERATION: Gloomier Prospects for Indo-U.S. Nuclear Pact

Richard Stone and Pallava Bagla
Science 25 May 2007: 1112.
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GENETICS: Working the (Gene Count) Numbers: Finally, a Firm Answer?

Elizabeth Pennisi
Science 25 May 2007: 1113.
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ScienceScope

Science 25 May 2007: 1111.
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Random Samples

Science 25 May 2007: 1105.
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Newsmakers

Science 25 May 2007: 1107.
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News Focus

AGBIOTECH: A Growing Threat Down on the Farm

Robert F. Service
Science 25 May 2007: 1114-1117.
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AGBIOTECH: Glyphosate--The Conservationist's Friend?

Robert F. Service
Science 25 May 2007: 1116-1117.
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ANTONIO GIORDANO PROFILE: 'Dr. Hustle' Sells His Dream for Italian Medical Research

Elisabeth Pain
Science 25 May 2007: 1118-1119.
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DNA SEQUENCING: A New Window on How Genomes Work

Elizabeth Pennisi
Science 25 May 2007: 1120-1121.
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Letters

This Week's Letters

Science 25 May 2007: 1122.
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 Lessons from Science Communication Training

Dana R. Warren, Marissa S. Weiss, David W. Wolfe, Blaine Friedlander, and Bruce Lewenstein
Science 25 May 2007: 1122.
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 Establishing Rights over the Arctic Ocean

Ron Macnab;, Trine Dahl-Jensen, and Kai Sørensen
Science 25 May 2007: 1122-1123.
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 The March of HIV Vaccines

Adel Mahmoud
Science 25 May 2007: 1123-1124.
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 Corrections and Clarifications

Science 25 May 2007: 1124.
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Books et al.

PHILOSOPHY OF MIND: Who Watches the Watcher?

Christoph C. Adami
Science 25 May 2007: 1125-1126.
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GENETICS: More Means of Regulating Genes

Armelle Corpet and Geneviève Almouzni
Science 25 May 2007: 1126-1127.
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Browsing

Science 25 May 2007: 1127.
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Books Received

Science 25 May 2007: 1127.
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Education Forum

MATHEMATICS: Cognitive Supports for Analogies in the Mathematics Classroom

Lindsey E. Richland, Osnat Zur, and Keith J. Holyoak
Science 25 May 2007: 1128-1129.
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Perspectives

APPLIED PHYSICS: One Electron Makes Current Flow

Stephen Giblin
Science 25 May 2007: 1130-1131.
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CHEMISTRY: The Direct Approach

Jonathan A. Ellman
Science 25 May 2007: 1131-1132.
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ASTRONOMY: Dark Matter in Galactic Collisional Debris

Bruce G. Elmegreen
Science 25 May 2007: 1132-1133.
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MATERIALS SCIENCE: Hydrogel Cell Cultures

Melinda C. Cushing and Kristi S. Anseth
Science 25 May 2007: 1133-1134.
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PHYSIOLOGY: Proteasomes Keep the Circadian Clock Ticking

David Gatfield and Ueli Schibler
Science 25 May 2007: 1135-1136.
Published online 10 May 2007 [DOI: 10.1126/science.1144165] (in Science Express Perspectives)
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GEOLOGY: Assessing Landslide Hazards

David K. Keefer and Matthew C. Larsen
Science 25 May 2007: 1136-1138.
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CELL SIGNALING: A Touching Response to Damage

John H. J. Petrini
Science 25 May 2007: 1138-1139.
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Association Affairs

AAAS News and Notes

Science 25 May 2007: 1140-1141.
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Brevia

Visual Language Discrimination in Infancy

Whitney M. Weikum, Athena Vouloumanos, Jordi Navarra, Salvador Soto-Faraco, Núria Sebastián-Gallés, and Janet F. Werker
Science 25 May 2007: 1159.
Before they are 8 months old, infants can tell whether someone is speaking French or English just by watching the speaker's face, but afterward they lose this ability. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Article

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Shuhei Matsuoka, Bryan A. Ballif, Agata Smogorzewska, E. Robert McDonald, III, Kristen E. Hurov, Ji Luo, Corey E. Bakalarski, Zhenming Zhao, Nicole Solimini, Yaniv Lerenthal, Yosef Shiloh, Steven P. Gygi, and Stephen J. Elledge
Science 25 May 2007: 1160-1166.
A proteomic analysis reveals that DNA damage induces phosphorylation of hundreds of proteins, many of which were not previously associated with this response. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Missing Mass in Collisional Debris from Galaxies

Frédéric Bournaud, Pierre-Alain Duc, Elias Brinks, Médéric Boquien, Philippe Amram, Ute Lisenfeld, Bärbel S. Koribalski, Fabian Walter, and Vassilis Charmandaris
Science 25 May 2007: 1166-1169.
Published online 10 May 2007 [DOI: 10.1126/science.1142114] (in Science Express Reports)
The motion of gas clouds in dwarf galaxies shows that they surprisingly contain dark matter, perhaps unseen cold molecular gas that could be more common than thought. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

An On-Demand Coherent Single-Electron Source

G. Fève, A. Mahé, J.-M. Berroir, T. Kontos, B. Plaçais, D. C. Glattli, A. Cavanna, B. Etienne, and Y. Jin
Science 25 May 2007: 1169-1172.
A quantum dot coupled to a two-dimensional electron gas yields single electrons on demand for use in quantum electronics and as an alternating current standard. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Catalytic Cross-Coupling of Unactivated Arenes

David R. Stuart and Keith Fagnou
Science 25 May 2007: 1172-1175.
A palladium complex can directly couple two aromatic molecules, an important step in many industrial reactions that usually requires separate modification of each molecule. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Chondrite Barium, Neodymium, and Samarium Isotopic Heterogeneity and Early Earth Differentiation

Richard W. Carlson, Maud Boyet, and Mary Horan
Science 25 May 2007: 1175-1178.
Neodymium and barium isotopes in meteorites reveal nucleosynthetic anomalies in the early solar system but not enough to rule out early differentiation of Earth's mantle. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Evidence for a Late Supernova Injection of ⁶⁰Fe into the Protoplanetary Disk

Martin Bizzarro, David Ulfbeck, Anne Trinquier, Kristine Thrane, James N. Connelly, and Bradley S. Meyer
Science 25 May 2007: 1178-1181.
Anomalous iron isotopes in meteorites from early planetesimals suggest that material from a nearby supernova polluted our solar system 1 million years after its formation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Model Projections of an Imminent Transition to a More Arid Climate in Southwestern North America

Richard Seager, Mingfang Ting, Isaac Held, Yochanan Kushnir, Jian Lu, Gabriel Vecchi, Huei-Ping Huang, Nili Harnik, Ants Leetmaa, Ngar-Cheung Lau, Cuihua Li, Jennifer Velez, and Naomi Naik
Science 25 May 2007: 1181-1184.
Published online 5 April 2007 [DOI: 10.1126/science.1139601] (in Science Express Reports)
A collection of 19 climate models predict that southwestern North America will dry significantly in the coming century, a transition that may already be under way. Abstract »|   Full Text »|   PDF »|  

Dicamba Resistance: Enlarging and Preserving Biotechnology-Based Weed Management Strategies

Mark R. Behrens, Nedim Mutlu, Sarbani Chakraborty, Razvan Dumitru, Wen Zhi Jiang, Bradley J. LaVallee, Patricia L. Herman, Thomas E. Clemente, and Donald P. Weeks
Science 25 May 2007: 1185-1188.
Soybean and other crops engineered to be resistant to dicamba, an environmentally friendly herbicide, will be useful as weeds become resistant to other herbicides. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Manganese(IV)/Iron(III) Cofactor in Chlamydia trachomatis Ribonucleotide Reductase

Wei Jiang, Danny Yun, Lana Saleh, Eric W. Barr, Gang Xing, Lee M. Hoffart, Monique-Anne Maslak, Carsten Krebs, and J. Martin Bollinger, Jr.
Science 25 May 2007: 1188-1191.
A pathogenic bacterium makes DNA precursors via an enzyme with a high-valent metal center; this helps it elude the human immune system and may mimic the RNA world. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell

Johan Elf, Gene-Wei Li, and X. Sunney Xie
Science 25 May 2007: 1191-1194.
A repressor protein in Escherichia coli spends about 90 percent of its time diffusing along DNA, falling off and trying again if it does not find its specific binding site within 5 ms. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

Bin Wang, Shuhei Matsuoka, Bryan A. Ballif, Dong Zhang, Agata Smogorzewska, Steven P. Gygi, and Stephen J. Elledge
Science 25 May 2007: 1194-1198.
The breast cancer tumor suppressor BRCA1 is recruited to sites of DNA damage by partner proteins that help it to recognize ubiquitinated proteins. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

Bijan Sobhian, Genze Shao, Dana R. Lilli, Aedín C. Culhane, Lisa A. Moreau, Bing Xia, David M. Livingston, and Roger A. Greenberg
Science 25 May 2007: 1198-1202.
A ubiquitin-binding protein targets the breast cancer tumor suppressor BRCA1 to sites of DNA damage and is required for the subsequent arrest of the cell cycle. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

Hongtae Kim, Junjie Chen, and Xiaochun Yu
Science 25 May 2007: 1202-1205.
A ubiquitin-binding protein targets the breast cancer tumor suppressor BRCA1 to sites of DNA damage and is required for the subsequent arrest of the cell cycle. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

How Synaptotagmin Promotes Membrane Fusion

Sascha Martens, Michael M. Kozlov, and Harvey T. McMahon
Science 25 May 2007: 1205-1208.
Published online 3 May 2007 [DOI: 10.1126/science.1142614] (in Science Express Reports)
A synaptic vesicle protein completes the final steps of membrane fusion by causing membrane curvature when triggered by a pulse of calcium. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Myosin V Walks by Lever Action and Brownian Motion

Katsuyuki Shiroguchi and Kazuhiko Kinosita, Jr.
Science 25 May 2007: 1208-1212.
As a two-headed molecular motor walks along actin, the bound leading head biases the rotational Brownian motion of the unbound head so that it lands on a forward site. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity

Paul Berghuis, Ann M. Rajnicek, Yury M. Morozov, Ruth A. Ross, Jan Mulder, Gabriella M. Urbán, Krisztina Monory, Giovanni Marsicano, Michela Matteoli, Alison Canty, Andrew J. Irving, István Katona, Yuchio Yanagawa, Pasko Rakic, Beat Lutz, Ken Mackie, and Tibor Harkany
Science 25 May 2007: 1212-1216.
Endocannabinoids can inhibit the growth of axons; mice without one type of cannabinoid receptor have more inhibitory neuronal inputs to cortical areas of the brain. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

Comment on "Dispersal Limitations Matter for Microbial Morphospecies"

Jason Pither
Science 25 May 2007: 1124.
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Response to Comment on "Dispersal Limitations Matter for Microbial Morphospecies"

Richard J. Telford, Vigdis Vandvik, and H. J. B. Birks
Science 25 May 2007: 1124.
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