Cell Signaling

Size, Mates, and Fates

Nancy R. Gough, Elizabeth M. Adler, and L. Bryan Ray
Science 1 December 2006: 1409.
Summary »|   PDF »|  

Perspectives

Brassinosteroid Signaling: A Paradigm for Steroid Hormone Signaling from the Cell Surface

Youssef Belkhadir and Joanne Chory
Science 1 December 2006: 1410-1411.
Abstract »|   Full Text »|   PDF »|  

G Protein Signaling in Yeast: New Components, New Connections, New Compartments

Janna E. Slessareva and Henrik G. Dohlman
Science 1 December 2006: 1412-1413.
Abstract »|   Full Text »|   PDF »|  

Notch, a Universal Arbiter of Cell Fate Decisions

Matthias Ehebauer, Penelope Hayward, and Alfonso Martinez Arias
Science 1 December 2006: 1414-1415.
Abstract »|   Full Text »|   PDF »|  

This Week in Science

Editor summaries of this week's papers.
Science 1 December 2006: 1349.
|Full Text »

Editorial:
Responding to Fraud

Donald Kennedy
Science 1 December 2006: 1353.
Summary »|   PDF »|   Supporting Online Material »|  

Editors' Choice

Highlights of the recent literature.
Science 1 December 2006: 1355.
|Full Text »

NEW PRODUCTS

Science 1 December 2006: 1471.
Summary »|   PDF »|  

News of the Week

SCIENTIFIC CONDUCT: China's Fraud Buster Hit by Libel Judgments; Defenders Rally Round

Jia Hepeng and Hao Xin
Science 1 December 2006: 1366-1367.
Summary »|   Full Text »|   PDF »|  

DEVELOPMENTAL BIOLOGY: Fraud Investigation Clouds Paper on Early Cell Fate

Gretchen Vogel
Science 1 December 2006: 1367-1369.
Summary »|   Full Text »|   PDF »|  

MEDICINE: Squelching Progesterone's Signal May Prevent Breast Cancer

Jean Marx
Science 1 December 2006: 1370.
Summary »|   Full Text »|   PDF »|  

MOLECULAR BIOLOGY: Three Methods Add Up to One New Way to Genetically Engineer Fruit Flies

Jennifer Couzin
Science 1 December 2006: 1371.
Summary »|   Full Text »|   PDF »|  

DRUG RESEARCH: WHO Panel Weighs Radical Ideas

Martin Enserink
Science 1 December 2006: 1373.
Summary »|   Full Text »|   PDF »|  

ScienceScope

Science 1 December 2006: 1369.
|Full Text »

Random Samples

Science 1 December 2006: 1363.
|Full Text »

Newsmakers

Science 1 December 2006: 1365.
|Full Text »

News Focus

SCIENCE EDUCATION: Doing More With Less

Jeffrey Mervis
Science 1 December 2006: 1374-1376.
Summary »|   Full Text »|   PDF »|  

ASTROPHYSICS: Burst-Hunter's Rich Data Harvest Yields a Cosmic Enigma

Tom Siegfried
Science 1 December 2006: 1376-1377.
Summary »|   Full Text »|   PDF »|  

GLOBAL HEALTH: South Africa Bolsters HIV/AIDS Plan, but Obstacles Remain

Robert Koenig
Science 1 December 2006: 1378-1379.
Summary »|   Full Text »|   PDF »|  

WILDLIFE CONSERVATION: The Saola's Last Stand

Richard Stone
Science 1 December 2006: 1380-1383.
Summary »|   Full Text »|   PDF »|  

Letters

This Week's Letters

Science 1 December 2006: 1387.
Summary »|   PDF »|  

 Balancing Communication and Safety

Susan A. Ehrlich
Science 1 December 2006: 1387.
Full Text »|   PDF »|  

 Glossing Over the Complexity of Water

Giorgos Kallis, Michael Kiparsky, Anita Milman, and Isha Ray
Science 1 December 2006: 1387-1388.
Full Text »|   PDF »|  

 Mitochondrial DNA and Population Size

Oliver F. Berry;, John P. Wares, Paul H. Barber, Jeffrey Ross-Ibarra, Erik E. Sotka, Robert J. Toonen;, E. Bazin, S. Glémin, and N. Galtier
Science 1 December 2006: 1388-1390.
Full Text »|   PDF »|  

Books et al.

EVOLUTION: A Subaltern View of Eusociality

Raghavendra Gadagkar
Science 1 December 2006: 1391-1392.
Summary »|   Full Text »|   PDF »|  

ENVIRONMENT AND RELIGION: Hoping to Establish Common Ground for Saving Biodiversity

Steven Bouma-Prediger
Science 1 December 2006: 1392-1393.
Summary »|   Full Text »|   PDF »|  

NOTA BENE: EXHIBITS: Delightful Digital Diversions

Andrew M. Sugden, Hugh A. Russell, and Rowan M. A. Sugden
Science 1 December 2006: 1393.
Summary »|   Full Text »|   PDF »|  

Books Received

Science 1 December 2006: 1393.
Summary »|  

Policy Forum

SCIENCE AND LAW: When Patents Threaten Science

Lori Andrews, Jordan Paradise, Timothy Holbrook, and Danielle Bochneak
Science 1 December 2006: 1395-1396.
Summary »|   Full Text »|   PDF »|  

Perspectives

DEVELOPMENTAL BIOLOGY: The Turing Model Comes of Molecular Age

Philip K. Maini, Ruth E. Baker, and Cheng-Ming Chuong
Science 1 December 2006: 1397-1398.
Summary »|   Full Text »|   PDF »|  

ASTRONOMY: Variable High-Energy γ Rays from the Elliptical Galaxy M87

A. C. Fabian
Science 1 December 2006: 1398-1399.
Summary »|   Full Text »|   PDF »|  

ATMOSPHERE: When Dry Air Is Too Humid

Thomas Peter, Claudia Marcolli, Peter Spichtinger, Thierry Corti, Marcia B. Baker, and Thomas Koop
Science 1 December 2006: 1399-1402.
Summary »|   Full Text »|   PDF »|  

CELL BIOLOGY: Tools to Tamper with Phosphoinositides

Stuart McLaughlin
Science 1 December 2006: 1402-1403.
Published online 9 November 2006 [DOI: 10.1126/science.1136314] (in Science Express Perspectives)
Summary »|   Full Text »|   PDF »|  

GENETICS: Enhanced: Delivering New Disease Genes

Lon R. Cardon
Science 1 December 2006: 1403-1405.
Summary »|   Full Text »|   PDF »|  

RETROSPECTIVE: Edward I. Stiefel (1942-2006)

Francois M. M. Morel and John T. Groves
Science 1 December 2006: 1406.
Summary »|   Full Text »|   PDF »|  

Brevia

Old-Growth Forests Can Accumulate Carbon in Soils

Guoyi Zhou, Shuguang Liu, Zhian Li, Deqiang Zhang, Xuli Tang, Chuanyan Zhou, Junhua Yan, and Jiangming Mo
Science 1 December 2006: 1417.
Old-growth forests in Southern China accumulated atmospheric carbon at a rate considerably greater than expected for broadleaved evergreen forests. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Article

Phytoplankton and Cloudiness in the Southern Ocean

Nicholas Meskhidze and Athanasios Nenes
Science 1 December 2006: 1419-1423.
Published online 2 November 2006 [DOI: 10.1126/science.1131779] (in Science Express Research Articles)
Oxidation of aerosols released from a phytoplankton bloom doubled the number of droplets in overlying clouds and reflected solar radiation as much as severe air pollution. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Fast Variability of Tera–Electron Volt Rays from the Radio Galaxy M87

F. Aharonian, A. G. Akhperjanian, A. R. Bazer-Bachi, M. Beilicke, W. Benbow, D. Berge, K. Bernlöhr, C. Boisson, O. Bolz, V. Borrel, I. Braun, A. M. Brown, R. Bühler, I. Büsching, S. Carrigan, P. M. Chadwick, L.-M. Chounet, G. Coignet, R. Cornils, L. Costamante, B. Degrange, H. J. Dickinson, A. Djannati-Ataï, L. O'C. Drury, G. Dubus, K. Egberts, D. Emmanoulopoulos, P. Espigat, F. Feinstein, E. Ferrero, A. Fiasson, G. Fontaine, Seb. Funk, S. Funk, M. Füßling, Y. A. Gallant, B. Giebels, J. F. Glicenstein, P. Goret, C. Hadjichristidis, D. Hauser, M. Hauser, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, E. Kendziorra, M. Kerschhaggl, B. Khélifi, Nu. Komin, A. Konopelko, K. Kosack, G. Lamanna, I. J. Latham, R. Le Gallou, A. Lemière, M. Lemoine-Goumard, J.-P. Lenain, T. Lohse, J. M. Martin, O. Martineau-Huynh, A. Marcowith, C. Masterson, G. Maurin, T. J. L. McComb, E. Moulin, M. de Naurois, D. Nedbal, S. J. Nolan, A. Noutsos, K. J. Orford, J. L. Osborne, M. Ouchrif, M. Panter, G. Pelletier, S. Pita, G. Pühlhofer, M. Punch, S. Ranchon, B. C. Raubenheimer, M. Raue, S. M. Rayner, A. Reimer, J. Ripken, L. Rob, L. Rolland, S. Rosier-Lees, G. Rowell, V. Sahakian, A. Santangelo, L. Saugé, S. Schlenker, R. Schlickeiser, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, H. Sol, D. Spangler, F. Spanier, R. Steenkamp, C. Stegmann, G. Superina, P. H. Tam, J.-P. Tavernet, R. Terrier, M. Tluczykont, C. van Eldik, G. Vasileiadis, C. Venter, J. P. Vialle, P. Vincent, H. J. Völk, S. J. Wagner, and M. Ward
Science 1 December 2006: 1424-1427.
Published online 26 October 2006 [DOI: 10.1126/science.1134408] (in Science Express Reports)
Very-high-energy gamma rays from the radio galaxy M87 vary daily, implying that they originate close to the central supermassive black hole. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Solid-State Qubits with Current-Controlled Coupling

T. Hime, P. A. Reichardt, B. L. T. Plourde, T. L. Robertson, C.-E. Wu, A. V. Ustinov, and John Clarke
Science 1 December 2006: 1427-1429.
Manipulation of the mutual inductance between two qubits can be used to switch their coupling on and off. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Optical Atomic Coherence at the 1-Second Time Scale

Martin M. Boyd, Tanya Zelevinsky, Andrew D. Ludlow, Seth M. Foreman, Sebastian Blatt, Tetsuya Ido, and Jun Ye
Science 1 December 2006: 1430-1433.
A highly stable laser and the ability to trap a large number of atoms coherently provide a tenfold increase in measuring spectral lines needed for precision applications. Abstract »|   Full Text »|   PDF »|  

Macroscopic Hierarchical Surface Patterning of Porphyrin Trimers via Self-Assembly and Dewetting

Richard van Hameren, Peter Schön, Arend M. van Buul, Johan Hoogboom, Sergiy V. Lazarenko, Jan W. Gerritsen, Hans Engelkamp, Peter C. M. Christianen, Hans A. Heus, Jan C. Maan, Theo Rasing, Sylvia Speller, Alan E. Rowan, Johannes A. A. W. Elemans, and Roeland J. M. Nolte
Science 1 December 2006: 1433-1436.
Upon dewetting, a molecule containing porphyrin and long alkyl groups can self-assemble in long chains and patterns over areas as large as several square millimeters. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Probing the Chiroptical Response of a Single Molecule

Ruthanne Hassey, Ellen J. Swain, Nathan I. Hammer, Dhandapani Venkataraman, and Michael D. Barnes
Science 1 December 2006: 1437-1439.
Published online 2 November 2006 [DOI: 10.1126/science.1134231] (in Science Express Reports)
Circular dichroism spectra at high resolution reveal that weak aggregate signals arise because the effects of distinct conformations in a chiral ensemble cancel each other. Abstract »|   Full Text »|   PDF »|  

Organic Globules in the Tagish Lake Meteorite: Remnants of the Protosolar Disk

Keiko Nakamura-Messenger, Scott Messenger, Lindsay P. Keller, Simon J. Clemett, and Michael E. Zolensky
Science 1 December 2006: 1439-1442.
Carbon-rich nanospheres in a primitive meteorite are relatively enriched in the heavy nitrogen isotopes and deuterium, suggesting that these grains have a pre-solar origin. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Increasing Trend of Extreme Rain Events Over India in a Warming Environment

B. N. Goswami, V. Venugopal, D. Sengupta, M. S. Madhusoodanan, and Prince K. Xavier
Science 1 December 2006: 1442-1445.
The frequency and intensity of heavy rainfall events during monsoon storms in Central India have increased during the past 50 years as the climate there has warmed. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Male Fertility and Sex Ratio at Birth in Red Deer

Montserrat Gomendio, Aurelio F. Malo, Ana J. Soler, Maria R. Fernández-Santos, Milagros C. Esteso, Andrés J. García, Eduardo R. S. Roldan, and Julian Garde
Science 1 December 2006: 1445-1447.
Like females, males can affect offspring sex ratio; more-fertile male red deer sire more sons and less-fertile males sire more daughters. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

WNT and DKK Determine Hair Follicle Spacing Through a Reaction-Diffusion Mechanism

Stefanie Sick, Stefan Reinker, Jens Timmer, and Thomas Schlake
Science 1 December 2006: 1447-1450.
Published online 2 November 2006 [DOI: 10.1126/science.1130088] (in Science Express Reports)
Modeling and experimental tests explain how a growth factor and its inhibitor determine the density and pattern of hair follicles in the developing mouse. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Structural Basis for Ribosome Recruitment and Manipulation by a Viral IRES RNA

Jennifer S. Pfingsten, David A. Costantino, and Jeffrey S. Kieft
Science 1 December 2006: 1450-1454.
Published online 23 November 2006 [DOI: 10.1126/science.1133281] (in Science Express Reports)
The structure of a viral RNA containing an internal ribosomal entry site suggests how translation can begin in the middle of a messenger RNA. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Rapid Chemically Induced Changes of PtdIns(4,5)P₂ Gate KCNQ Ion Channels

Byung-Chang Suh, Takanari Inoue, Tobias Meyer, and Bertil Hille
Science 1 December 2006: 1454-1457.
Published online 21 September 2006 [DOI: 10.1126/science.1131163] (in Science Express Reports)
Neurotransmitters close a potassium channel by changing the lipid content of the surrounding plasma membrane. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

PI(3,4,5)P₃ and PI(4,5)P₂ Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane

Won Do Heo, Takanari Inoue, Wei Sun Park, Man Lyang Kim, Byung Ouk Park, Thomas J. Wandless, and Tobias Meyer
Science 1 December 2006: 1458-1461.
Published online 9 November 2006 [DOI: 10.1126/science.1134389] (in Science Express Reports)
Two phospholipid signaling molecules are also essential to anchor proteins that have clusters of basic amino acids to the cell membrane. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Richard H. Duerr, Kent D. Taylor, Steven R. Brant, John D. Rioux, Mark S. Silverberg, Mark J. Daly, A. Hillary Steinhart, Clara Abraham, Miguel Regueiro, Anne Griffiths, Themistocles Dassopoulos, Alain Bitton, Huiying Yang, Stephan Targan, Lisa Wu Datta, Emily O. Kistner, L. Philip Schumm, Annette T. Lee, Peter K. Gregersen, M. Michael Barmada, Jerome I. Rotter, Dan L. Nicolae, and Judy H. Cho
Science 1 December 2006: 1461-1463.
Published online 26 October 2006 [DOI: 10.1126/science.1135245] (in Science Express Reports)
People with a rare sequence variant of the gene encoding the receptor for an immunological cytokine have a reduced risk of inflammatory bowel disease. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Microfluidic Digital PCR Enables Multigene Analysis of Individual Environmental Bacteria

Elizabeth A. Ottesen, Jong Wook Hong, Stephen R. Quake, and Jared R. Leadbetter
Science 1 December 2006: 1464-1467.
A DNA analysis method that can link genes to individual organisms collected in the wild is used to identify a gut symbiont of the termite. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Prevention of Brca1-Mediated Mammary Tumorigenesis in Mice by a Progesterone Antagonist

Aleksandra Jovanovic Poole, Ying Li, Yoon Kim, Suh-Chin J. Lin, Wen-Hwa Lee, and Eva Y.-H. P. Lee
Science 1 December 2006: 1467-1470.
Experiments in mice suggest that a mutation leading to breast cancer acts in part by altering signaling by the steroid hormone progesterone. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

Comment on "Population Size Does Not Influence Mitochondrial Genetic Diversity in Animals"

Connie J. Mulligan, Andrew Kitchen, and Michael M. Miyamoto
Science 1 December 2006: 1390.
Abstract »|   Full Text »|   PDF »|