Genomic Evolution: Building the Body from Genes

Genomic Tales

Barbara R. Jasny, Elizabeth Pennisi, and John Travis
Science 29 September 2006: 1907.
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News

Mining the Molecules That Made Our Mind

Elizabeth Pennisi
Science 29 September 2006: 1908-1911.
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The Evolution of Function & Form

Science 29 September 2006: 1912-1913.
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Reviews

Casting a Genetic Light on the Evolution of Eyes

Russell D. Fernald
Science 29 September 2006: 1914-1918.
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Genomic Evolution of Hox Gene Clusters

Derek Lemons and William McGinnis
Science 29 September 2006: 1918-1922.
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Gene Regulatory Networks in the Evolution and Development of the Heart

Eric N. Olson
Science 29 September 2006: 1922-1927.
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This Week in Science

Editor summaries of this week's papers.
Science 29 September 2006: 1849.
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Editorial:
Genetic Testing Oversight

Kathy L. Hudson
Science 29 September 2006: 1853.
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Editors' Choice

Highlights of the recent literature.
Science 29 September 2006: 1855.
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NetWatch

Best of the Web in science.
Science 29 September 2006: 1861.
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Science Podcast

Science 29 September 2006: 1979.
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NEW PRODUCTS

Science 29 September 2006: 1979.
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News of the Week

GENETICS: Pollen Contamination May Explain Controversial Inheritance

Elizabeth Pennisi
Science 29 September 2006: 1864.
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GEOLOGY: Mud Eruption Threatens Villagers in Java

Dennis Normile
Science 29 September 2006: 1865.
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PLANT SCIENCE: Parasitic Weed Uses Chemical Cues to Find Host Plant

Elizabeth Pennisi
Science 29 September 2006: 1867.
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IMMUNOLOGY: Study Says HIV Blood Levels Don't Predict Immune Decline

Jon Cohen
Science 29 September 2006: 1868.
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CANCER: T Cells a Boon for Colon Cancer Prognosis

Jennifer Couzin
Science 29 September 2006: 1868-1869.
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STEM CELLS: Scientists Create Human Stem Cell Line From 'Dead' Embryos

Constance Holden
Science 29 September 2006: 1869.
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CLIMATE CHANGE: Royal Society Takes a Shot at ExxonMobil

Eliot Marshall
Science 29 September 2006: 1871.
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ASTRONOMY: Search for Giant Scope Site Narrows to Two

Robert Koenig
Science 29 September 2006: 1871.
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ScienceScope

Science 29 September 2006: 1867.
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Random Samples

Science 29 September 2006: 1863.
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Newsmakers

Science 29 September 2006: 1883.
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News Focus

DOE SCIENCE: Embracing Small Science in a Big Way

Adrian Cho
Science 29 September 2006: 1872-1875.
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DOE SCIENCE: A Manager Who Cashes In on Consensus

Eli Kintisch
Science 29 September 2006: 1873.
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DOE SCIENCE: Ray Orbach Asks Science to Serve Society

Eli Kintisch
Science 29 September 2006: 1874.
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ARTHUR DEMAREST PROFILE: Living Among the Maya, Past and Present

Michael Bawaya
Science 29 September 2006: 1876-1877.
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NEUROSCIENCE: 'Google of the Brain': Atlas Maps Brain's Genetic Activity

Yudhijit Bhattacharjee
Science 29 September 2006: 1879.
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PASCOS 2006: Neutrino Physics Probes Mysteries of 'Flavor' and Origins

Tom Siegfried
Science 29 September 2006: 1880.
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PASCOS 2006: A Cosmic-Scale Test for String Theory?

Tom Siegfried
Science 29 September 2006: 1880-1881.
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PASCOS 2006: Snapshots From the Meeting

Tom Siegfried
Science 29 September 2006: 1881.
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Letters

This Week's Letters

Science 29 September 2006: 1885.
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 A Fresh Look at Innovation and Security

David McCormick
Science 29 September 2006: 1885.
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 Does the World Really Need More Babies?

Ben Zuckerman
Science 29 September 2006: 1885-1886.
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 Balancing Fertility Rates with Resources

Richard A. Grossman and Richard E. White
Science 29 September 2006: 1886-1887.
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 Corrections and Clarifications

Science 29 September 2006: 1887.
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Books et al.

MEDICINE: The Politics of Hope--Dreaming in a Genomic Age

Sandra Soo-Jin Lee
Science 29 September 2006: 1889-1890.
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SCIENCE AND RELIGION: DNA, Evolution, and the Moral Law

Robert Pollack
Science 29 September 2006: 1890-1891.
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MOLECULAR BIOLOGY: From Magnetic Mines to DNA and Consciousness

Leslie Orgel
Science 29 September 2006: 1891-1892.
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GENOMICS: An Ointment for the Fly

J. Craig Venter
Science 29 September 2006: 1892.
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Books Received

Science 29 September 2006: 1892.
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Education Forum

THE EARLY YEARS: Evaluating Montessori Education

Angeline Lillard and Nicole Else-Quest
Science 29 September 2006: 1893-1894.
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Perspectives

APPLIED PHYSICS: Tuning Interface States

Harold Y. Hwang
Science 29 September 2006: 1895-1896.
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GEOCHEMISTRY: Manganese Redox Chemistry Revisited

Kenneth S. Johnson
Science 29 September 2006: 1896-1897.
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GENOMICS: Genomics and the Tree of Life

Antonis Rokas
Science 29 September 2006: 1897-1899.
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PLANETARY SCIENCE: Merging Views on Mars

Jean-Pierre Bibring, Steven W. Squyres, and Raymond E. Arvidson
Science 29 September 2006: 1899-1901.
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CHEMISTRY: Unveiling the Membrane Domains

Jay T. Groves
Science 29 September 2006: 1901-1902.
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IMMUNOLOGY: Restless T Cells Sniff and Go

Tomas Mustelin
Science 29 September 2006: 1902-1903.
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Association Affairs

AAAS News and Notes

Science 29 September 2006: 1904-1905.
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Brevia

Elevated Eocene Atmospheric CO₂ and Its Subsequent Decline

Tim K. Lowenstein and Robert V. Demicco
Science 29 September 2006: 1928.
The atmospheric concentration of carbon dioxide during a warm period 50 million years ago was at least 1125 parts per million by volume, four times the preindustrial value. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Justin Lamb, Emily D. Crawford, David Peck, Joshua W. Modell, Irene C. Blat, Matthew J. Wrobel, Jim Lerner, Jean-Philippe Brunet, Aravind Subramanian, Kenneth N. Ross, Michael Reich, Haley Hieronymus, Guo Wei, Scott A. Armstrong, Stephen J. Haggarty, Paul A. Clemons, Ru Wei, Steven A. Carr, Eric S. Lander, and Todd R. Golub
Science 29 September 2006: 1929-1935.
Comparison of mRNAs evoked by small molecules in human cells to mRNA expressed in diseases and in response to drugs suggests new therapeutic approaches. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Structure of the 70S Ribosome Complexed with mRNA and tRNA

Maria Selmer, Christine M. Dunham, Frank V. Murphy, IV, Albert Weixlbaumer, Sabine Petry, Ann C. Kelley, John R. Weir, and V. Ramakrishnan
Science 29 September 2006: 1935-1942.
Published online 7 September 2006 [DOI: 10.1126/science.1131127] (in Science Express Research Articles)
The structure of the bacterial ribosome complexed with mRNA and tRNA at 2.8 angstrom resolution shows the detailed interaction of the ribosome with its substrates and metal ions. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Tunable Quasi-Two-Dimensional Electron Gases in Oxide Heterostructures

S. Thiel, G. Hammerl, A. Schmehl, C. W. Schneider, and J. Mannhart
Science 29 September 2006: 1942-1945.
Published online 24 August 2006 [DOI: 10.1126/science.1131091] (in Science Express Reports)
Application of an electric field can tune the conductance of the interface region between layered oxides by orders of magnitude. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Ultrafast Vibrational Dynamics at Water Interfaces

John A. McGuire and Y. Ron Shen
Science 29 September 2006: 1945-1948.
Despite having a more ordered and terminated network of hydrogen bonds, water surfaces surprisingly have the same vibrational dynamics as bulk water. Abstract »|   Full Text »|   PDF »|  

Phase Separation of Lipid Membranes Analyzed with High-Resolution Secondary Ion Mass Spectrometry

Mary L. Kraft, Peter K. Weber, Marjorie L. Longo, Ian D. Hutcheon, and Steven G. Boxer
Science 29 September 2006: 1948-1951.
A mass spectrometry technique enables imaging of the lateral distribution and composition of lipids in cell membranes at a resolution near 100 nanometers. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Ultrafast Carbon-Carbon Single-Bond Rotational Isomerization in Room-Temperature Solution

Junrong Zheng, Kyungwon Kwak, Jia Xie, and M. D. Fayer
Science 29 September 2006: 1951-1955.
An infrared vibrational echo technique allows direct measurement of bond rotation rates in an ethane derivative on a time scale too fast to probe previously. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Soluble Mn(III) in Suboxic Zones

Robert E. Trouwborst, Brian G. Clement, Bradley M. Tebo, Brian T. Glazer, and George W. Luther, III
Science 29 September 2006: 1955-1957.
Manganese in the +3 oxidation state, which can be either an electron acceptor or donor, is identified in the Black Sea and Chesapeake Bay, in contrast to previous inferences. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Satellite Gravity Measurements Confirm Accelerated Melting of Greenland Ice Sheet

J. L. Chen, C. R. Wilson, and B. D. Tapley
Science 29 September 2006: 1958-1960.
Published online 10 August 2006 [DOI: 10.1126/science.1129007] (in Science Express Reports)
Satellite measurements of gravity variations show that the Greenland Ice Sheet now is disappearing at the rate of about 240 cubic kilometers per year. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Jérôme Galon, Anne Costes, Fatima Sanchez-Cabo, Amos Kirilovsky, Bernhard Mlecnik, Christine Lagorce-Pagès, Marie Tosolini, Matthieu Camus, Anne Berger, Philippe Wind, Franck Zinzindohoué, Patrick Bruneval, Paul-Henri Cugnenc, Zlatko Trajanoski, Wolf-Herman Fridman, and Franck Pagès
Science 29 September 2006: 1960-1964.
The progress of colorectal cancer in patients can be predicted from the characteristics of the immune cells found in their tumors. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Volatile Chemical Cues Guide Host Location and Host Selection by Parasitic Plants

Justin B. Runyon, Mark C. Mescher, and Consuelo M. De Moraes
Science 29 September 2006: 1964-1967.
A parasitic plant locates a preferred host by detecting its released odors; disrupting this process could help control parasites of crop plants. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Structure of the Exon Junction Core Complex with a Trapped DEAD-Box ATPase Bound to RNA

Christian B. F. Andersen, Lionel Ballut, Jesper S. Johansen, Hala Chamieh, Klaus H. Nielsen, Cristiano L. P. Oliveira, Jan Skov Pedersen, Bertrand Séraphin, Hervé Le Hir, and Gregers Rom Andersen
Science 29 September 2006: 1968-1972.
Published online 24 August 2006 [DOI: 10.1126/science.1131981] (in Science Express Reports)
A structure of a complex that binds to new mRNA reveals how two proteins inhibit the ATPase activity of an RNA helicase to ensure tight binding. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reversal of the TCR Stop Signal by CTLA-4

Helga Schneider, Jos Downey, Andrew Smith, Bernd H. Zinselmeyer, Catherine Rush, James M. Brewer, Bin Wei, Nancy Hogg, Paul Garside, and Christopher E. Rudd
Science 29 September 2006: 1972-1975.
Published online 24 August 2006 [DOI: 10.1126/science.1131078] (in Science Express Reports)
A protein responsible for preventing unwanted immune responses discourages extended liaisons between activated immune cells. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Dok-7 Mutations Underlie a Neuromuscular Junction Synaptopathy

David Beeson, Osamu Higuchi, Jackie Palace, Judy Cossins, Hayley Spearman, Susan Maxwell, John Newsom-Davis, Georgina Burke, Peter Fawcett, Masakatsu Motomura, Juliane S. Müller, Hanns Lochmüller, Clarke Slater, Angela Vincent, and Yuji Yamanashi
Science 29 September 2006: 1975-1978.
Published online 17 August 2006 [DOI: 10.1126/science.1130837] (in Science Express Reports)
An inherited muscle disease in which certain muscles are weak is caused by mutations in a protein needed for proper formation of the neuromuscular junction. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

Comment on "Asymmetric Coevolutionary Networks Facilitate Biodiversity Maintenance"

J. Nathaniel Holland, Toshinori Okuyama, and Donald L. DeAngelis
Science 29 September 2006: 1887.
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Response to Comment on "Asymmetric Coevolutionary Networks Facilitate Biodiversity Maintenance"

Jordi Bascompte, Pedro Jordano, and Jens M. Olesen
Science 29 September 2006: 1887.
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