CAREERS IN SYSTEMS BIOLOGY: Working the Systems

Jim Kling
Science 3 March 2006: 1305-1306.
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CAREERS IN SYSTEMS BIOLOGY: A Meeting of Minds, Expertise, and Imagination

Anne Forde
Science 3 March 2006: 1306-1307.
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This Week in Science

Editor summaries of this week's papers.
Science 3 March 2006: 1209.
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Editorial:
The Mailbag

Donald Kennedy
Science 3 March 2006: 1213.
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Editors' Choice

Highlights of the recent literature.
Science 3 March 2006: 1214.
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NetWatch

Best of the Web in science.
Science 3 March 2006: 1221.
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NEW PRODUCTS

Science 3 March 2006: 1304.
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News of the Week

AVIAN INFLUENZA: As H5N1 Keeps Spreading, a Call to Release More Data

Martin Enserink
Science 3 March 2006: 1224.
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AVIAN INFLUENZA: Evidence Points to Migratory Birds in H5N1 Spread

Dennis Normile
Science 3 March 2006: 1225.
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GENOMICS: DOE Hits Potholes on the Road to Systems Biology

Elizabeth Pennisi
Science 3 March 2006: 1226.
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SCIENTIFIC PUBLISHING: Canadian Editors Fired in Row With Association

Paul Webster
Science 3 March 2006: 1226.
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UNIVERSITIES: Despite a Chilly Reception, the 'European MIT' Advances

Daniel Clery
Science 3 March 2006: 1227.
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SCIENCE INDICATORS: NSF Presents the Wide World of Science

Jeffrey Mervis
Science 3 March 2006: 1228.
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SCIENCE AND DIPLOMACY: Indian Chemist Receives a Visa and an Apology

Pallava Bagla
Science 3 March 2006: 1229.
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ANIMAL RESEARCH: Protesters March to a Different Drummer

Eliot Marshall
Science 3 March 2006: 1229.
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ScienceScope

Science 3 March 2006: 1227.
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Random Samples

Science 3 March 2006: 1223.
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Newsmakers

Science 3 March 2006: 1239.
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News Focus

CONSERVATION BIOLOGY: The Lost World of the Kihansi Toad

Kevin Krajick
Science 3 March 2006: 1230-1232.
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CELL BIOLOGY: Great Balls of Fat

Mary Beckman
Science 3 March 2006: 1232-1234.
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WOMEN IN SCIENCE: Getting Women Scientists Back on the Career Track in Japan

Dennis Normile
Science 3 March 2006: 1235-1236.
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JAPAN: A $214 Billion Plan of Action

Dennis Normile
Science 3 March 2006: 1236.
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IOANNIS MIAOULIS PROFILE: A Passion for Teaching Leads to Engineering Change in Schools

Yudhijit Bhattacharjee
Science 3 March 2006: 1237-1238.
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Letters

This Week's Letters

Science 3 March 2006: 1240.
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 Crucial Choices for the Nascent ERC

Initiative for Science in Europe
Science 3 March 2006: 1240.
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 Objectivity in Science

Kenneth R. Gordon
Science 3 March 2006: 1240-1241.
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 Influenza Mutation from Equine to Canine

Marcin von Grotthuss, Leszek Rychlewski;, Patti C. Crawford, Edward J. Dubovi, William L. Castleman, Iain Stephenson, E. P. J. Gibbs, Limei Chen, Catherine Smith, Richard C. Hill, Pamela Ferro, Justine Pompey, Rick A. Bright, Marie-Jo Medina, Calvin M. Johnson, Christopher W. Olsen, Nancy J. Cox, Alexander I. Klimov, Jackie M. Katz, and Ruben O. Donis
Science 3 March 2006: 1241-1242.
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 Corrections and Clarifications

Science 3 March 2006: 1242.
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Books et al.

MICROBIOLOGY: Of Microbes, Medicine, and Ecology

James Strick
Science 3 March 2006: 1243.
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ASTROBIOLOGY: Deities for Atheists

Michael Shermer
Science 3 March 2006: 1244.
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Books Received

Science 3 March 2006: 1244.
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Policy Forum

PUBLIC HEALTH: Enhanced: A National Tuberculosis Archive

Damian Gessler, Christopher Dye, Paul Farmer, Megan Murray, Thomas Navin, Randall Reves, Thomas Shinnick, Peter M. Small, Terry Yates, and Gary Simpson
Science 3 March 2006: 1245-1246.
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MEDICINE: Enhanced: A Portfolio Model of Drug Development for Tuberculosis

Seth W. Glickman, Emma B. Rasiel, Carol Dukes Hamilton, Arsen Kubataev, and Kevin A. Schulman
Science 3 March 2006: 1246-1247.
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Perspectives

BEHAVIOR: Who Are More Helpful, Humans or Chimpanzees?

Joan B. Silk
Science 3 March 2006: 1248-1249.
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ANTHROPOLOGY: An Example of Preclassic Mayan Writing?

Stephen D. Houston
Science 3 March 2006: 1249-1250.
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PLANETARY SCIENCE: Creep and Flow on the Icy Moons of the Outer Planets

Peter R. Sammonds
Science 3 March 2006: 1250-1251.
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STRUCTURAL BIOLOGY: Architectural Options for a Fatty Acid Synthase

Stuart Smith
Science 3 March 2006: 1251-1252.
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Review

Auxiliary Subunits Assist AMPA-Type Glutamate Receptors

Roger A. Nicoll, Susumu Tomita, and David S. Bredt
Science 3 March 2006: 1253-1256.
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Brevia

Cellular Senescence in Aging Primates

Utz Herbig, Mark Ferreira, Laura Condel, Dee Carey, and John M. Sedivy
Science 3 March 2006: 1257.
Published online 2 February 2006 [DOI: 10.1126/science.1122446] (in Science Express Brevia)
As baboons age, cells that have become irreversibly senescent accumulate in various tissues, likely contributing to the aging of the whole animal. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

Architecture of Mammalian Fatty Acid Synthase at 4.5 Å Resolution

Timm Maier, Simon Jenni, and Nenad Ban
Science 3 March 2006: 1258-1262.
The large multiprotein complexes that synthesize fatty acids in mammals and fungi have radically different architectures. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Architecture of a Fungal Fatty Acid Synthase at 5 Å Resolution

Simon Jenni, Marc Leibundgut, Timm Maier, and Nenad Ban
Science 3 March 2006: 1263-1267.
The large multiprotein complexes that synthesize fatty acids in mammals and fungi have radically different architectures. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Grain Size-Sensitive Creep in Ice II

Tomoaki Kubo, William B. Durham, Laura A. Stern, and Stephen H. Kirby
Science 3 March 2006: 1267-1269.
Experiments show that grain size influences the deformation speed of ice under high pressure, modifying models of the evolution and internal dynamics of icy moons. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Giant Electrocaloric Effect in Thin-Film PbZr_0.95Ti_0.05O₃

A. S. Mischenko, Q. Zhang, J. F. Scott, R. W. Whatmore, and N. D. Mathur
Science 3 March 2006: 1270-1271.
Application of an electric field to a thin lead zirconium titanium oxide produces a surprisingly large drop in its temperature, suggesting a potential refrigeration technology. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Surface Self-Organization Caused by Dislocation Networks

Konrad Thürmer, Robert Q. Hwang, and Norman C. Bartelt
Science 3 March 2006: 1272-1274.
The organization of silver ions on a ruthenium surface depends on dislocations below the surface and not on strain or surface tension as had been thought. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Synthesis and Characterization of the Nitrides of Platinum and Iridium

Jonathan C. Crowhurst, Alexander F. Goncharov, Babak Sadigh, Cheryl L. Evans, Peter G. Morrall, James L. Ferreira, and A. J. Nelson
Science 3 March 2006: 1275-1278.
A platinum nitride produced at high pressure has a simple structure, and an iridium nitride can persist at ambient conditions and may be nearly as stiff as diamond. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Rotational Spectrum of the Water-Hydroperoxy Radical (H₂O-HO₂) Complex

Kohsuke Suma, Yoshihiro Sumiyoshi, and Yasuki Endo
Science 3 March 2006: 1278-1281.
Microwave spectroscopy reveals that a H₂O—HO₂ complex is pentagonal, offering a signature with which to probe its postulated role in atmospheric chemistry. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Early Maya Writing at San Bartolo, Guatemala

William A. Saturno, David Stuart, and Boris Beltrán
Science 3 March 2006: 1281-1283.
Published online 5 January 2006 [DOI: 10.1126/science.1121745] (in Science Express Reports)
Hieroglyphic writing adorns a buried stone building in the Maya temple of San Bartolo, Guatemala, dated to about 250 B.C., closer to when writing emerged in the New World. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Toward Automatic Reconstruction of a Highly Resolved Tree of Life

Francesca D. Ciccarelli, Tobias Doerks, Christian von Mering, Christopher J. Creevey, Berend Snel, and Peer Bork
Science 3 March 2006: 1283-1287.
Sequences of 36 genes in each of 191 diverse species allow construction of a highly resolved phylogenetic tree, which, when lateral gene transfer is eliminated, clarifies the tree of life. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Germline Mutations in Genes Within the MAPK Pathway Cause Cardio-facio-cutaneous Syndrome

Pablo Rodriguez-Viciana, Osamu Tetsu, William E. Tidyman, Anne L. Estep, Brenda A. Conger, Molly Santa Cruz, Frank McCormick, and Katherine A. Rauen
Science 3 March 2006: 1287-1290.
Published online 26 January 2006 [DOI: 10.1126/science.1124642] (in Science Express Reports)
Mutations that functionally alter an intensely studied cellular signaling pathway are found in young patients with a developmental delay disorder. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Combined Analog and Action Potential Coding in Hippocampal Mossy Fibers

Henrik Alle and Jörg R. P. Geiger
Science 3 March 2006: 1290-1293.
Synapses at one end of a neuron can be affected by graded synaptic currents at the other end, 0.5 millimeters away, suggesting that analog information is unexpectedly used in the brain. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Chemical Rescue of a Mutant Enzyme in Living Cells

Yingfeng Qiao, Henrik Molina, Akhilesh Pandey, Jin Zhang, and Philip A. Cole
Science 3 March 2006: 1293-1297.
Abnormal cells harboring a mutant signaling enzyme found in some cancers can be rapidly rescued by the small molecule imidazole, suggesting a therapeutic application. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Chimpanzees Recruit the Best Collaborators

Alicia P. Melis, Brian Hare, and Michael Tomasello
Science 3 March 2006: 1297-1300.
Like humans, chimps will preferentially recruit especially skilled species-mates to solve difficult problems. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Altruistic Helping in Human Infants and Young Chimpanzees

Felix Warneken and Michael Tomasello
Science 3 March 2006: 1301-1303.
Toddlers can recognize that an adult needs help with a task and assist, indicating empathy and altruism; young chimpanzees do the same, but less effectively. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|