The Trypanosomatid Genomes

Trypanosomatid Genomes

Caroline Ash and Barbara R. Jasny
Science 15 July 2005: 399.
Summary »|   PDF »|  

Viewpoint

Health Innovation Networks to Help Developing Countries Address Neglected Diseases

Carlos M. Morel, Tara Acharya, Denis Broun, Ajit Dangi, Christopher Elias, N. K. Ganguly, Charles A. Gardner, R. K. Gupta, Jane Haycock, Anthony D. Heher, Peter J. Hotez, Hannah E. Kettler, Gerald T. Keusch, Anatole F. Krattiger, Fernando T. Kreutz, Sanjaya Lall, Keun Lee, Richard Mahoney, Adolfo Martinez-Palomo, R. A. Mashelkar, Stephen A. Matlin, Mandi Mzimba, Joachim Oehler, Robert G. Ridley, Pramilla Senanayake, Peter Singer, and Mikyung Yun
Science 15 July 2005: 401-404.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

Comparative Genomics of Trypanosomatid Parasitic Protozoa

Najib M. El-Sayed, Peter J. Myler, Gaëlle Blandin, Matthew Berriman, Jonathan Crabtree, Gautam Aggarwal, Elisabet Caler, Hubert Renauld, Elizabeth A. Worthey, Christiane Hertz-Fowler, Elodie Ghedin, Christopher Peacock, Daniella C. Bartholomeu, Brian J. Haas, Anh-Nhi Tran, Jennifer R. Wortman, U. Cecilia M. Alsmark, Samuel Angiuoli, Atashi Anupama, Jonathan Badger, Frederic Bringaud, Eithon Cadag, Jane M. Carlton, Gustavo C. Cerqueira, Todd Creasy, Arthur L. Delcher, Appolinaire Djikeng, T. Martin Embley, Christopher Hauser, Alasdair C. Ivens, Sarah K. Kummerfeld, Jose B. Pereira-Leal, Daniel Nilsson, Jeremy Peterson, Steven L. Salzberg, Joshua Shallom, Joana C. Silva, Jaideep Sundaram, Scott Westenberger, Owen White, Sara E. Melville, John E. Donelson, Björn Andersson, Kenneth D. Stuart, and Neil Hall
Science 15 July 2005: 404-409.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

Najib M. El-Sayed, Peter J. Myler, Daniella C. Bartholomeu, Daniel Nilsson, Gautam Aggarwal, Anh-Nhi Tran, Elodie Ghedin, Elizabeth A. Worthey, Arthur L. Delcher, Gaëlle Blandin, Scott J. Westenberger, Elisabet Caler, Gustavo C. Cerqueira, Carole Branche, Brian Haas, Atashi Anupama, Erik Arner, Lena Åslund, Philip Attipoe, Esteban Bontempi, Frédéric Bringaud, Peter Burton, Eithon Cadag, David A. Campbell, Mark Carrington, Jonathan Crabtree, Hamid Darban, Jose Franco da Silveira, Pieter de Jong, Kimberly Edwards, Paul T. Englund, Gholam Fazelina, Tamara Feldblyum, Marcela Ferella, Alberto Carlos Frasch, Keith Gull, David Horn, Lihua Hou, Yiting Huang, Ellen Kindlund, Michele Klingbeil, Sindy Kluge, Hean Koo, Daniela Lacerda, Mariano J. Levin, Hernan Lorenzi, Tin Louie, Carlos Renato Machado, Richard McCulloch, Alan McKenna, Yumi Mizuno, Jeremy C. Mottram, Siri Nelson, Stephen Ochaya, Kazutoyo Osoegawa, Grace Pai, Marilyn Parsons, Martin Pentony, Ulf Pettersson, Mihai Pop, Jose Luis Ramirez, Joel Rinta, Laura Robertson, Steven L. Salzberg, Daniel O. Sanchez, Amber Seyler, Reuben Sharma, Jyoti Shetty, Anjana J. Simpson, Ellen Sisk, Martti T. Tammi, Rick Tarleton, Santuza Teixeira, Susan Van Aken, Christy Vogt, Pauline N. Ward, Bill Wickstead, Jennifer Wortman, Owen White, Claire M. Fraser, Kenneth D. Stuart, and Björn Andersson
Science 15 July 2005: 409-415.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Genome of the African Trypanosome Trypanosoma brucei

Matthew Berriman, Elodie Ghedin, Christiane Hertz-Fowler, Gaëlle Blandin, Hubert Renauld, Daniella C. Bartholomeu, Nicola J. Lennard, Elisabet Caler, Nancy E. Hamlin, Brian Haas, Ulrike Böhme, Linda Hannick, Martin A. Aslett, Joshua Shallom, Lucio Marcello, Lihua Hou, Bill Wickstead, U. Cecilia M. Alsmark, Claire Arrowsmith, Rebecca J. Atkin, Andrew J. Barron, Frederic Bringaud, Karen Brooks, Mark Carrington, Inna Cherevach, Tracey-Jane Chillingworth, Carol Churcher, Louise N. Clark, Craig H. Corton, Ann Cronin, Rob M. Davies, Jonathon Doggett, Appolinaire Djikeng, Tamara Feldblyum, Mark C. Field, Audrey Fraser, Ian Goodhead, Zahra Hance, David Harper, Barbara R. Harris, Heidi Hauser, Jessica Hostetler, Al Ivens, Kay Jagels, David Johnson, Justin Johnson, Kristine Jones, Arnaud X. Kerhornou, Hean Koo, Natasha Larke, Scott Landfear, Christopher Larkin, Vanessa Leech, Alexandra Line, Angela Lord, Annette MacLeod, Paul J. Mooney, Sharon Moule, David M. A. Martin, Gareth W. Morgan, Karen Mungall, Halina Norbertczak, Doug Ormond, Grace Pai, Chris S. Peacock, Jeremy Peterson, Michael A. Quail, Ester Rabbinowitsch, Marie-Adele Rajandream, Chris Reitter, Steven L. Salzberg, Mandy Sanders, Seth Schobel, Sarah Sharp, Mark Simmonds, Anjana J. Simpson, Luke Tallon, C. Michael R. Turner, Andrew Tait, Adrian R. Tivey, Susan Van Aken, Danielle Walker, David Wanless, Shiliang Wang, Brian White, Owen White, Sally Whitehead, John Woodward, Jennifer Wortman, Mark D. Adams, T. Martin Embley, Keith Gull, Elisabetta Ullu, J. David Barry, Alan H. Fairlamb, Fred Opperdoes, Barclay G. Barrell, John E. Donelson, Neil Hall, Claire M. Fraser, Sara E. Melville, and Najib M. El-Sayed
Science 15 July 2005: 416-422.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Trypanosomatid Genomes: Plates

Science 15 July 2005: 423-434.
Summary »|   Full Text »|   PDF »|   Plates »|  

The Genome of the Kinetoplastid Parasite, Leishmania major

Alasdair C. Ivens, Christopher S. Peacock, Elizabeth A. Worthey, Lee Murphy, Gautam Aggarwal, Matthew Berriman, Ellen Sisk, Marie-Adele Rajandream, Ellen Adlem, Rita Aert, Atashi Anupama, Zina Apostolou, Philip Attipoe, Nathalie Bason, Christopher Bauser, Alfred Beck, Stephen M. Beverley, Gabriella Bianchettin, Katja Borzym, Gordana Bothe, Carlo V. Bruschi, Matt Collins, Eithon Cadag, Laura Ciarloni, Christine Clayton, Richard M. R. Coulson, Ann Cronin, Angela K. Cruz, Robert M. Davies, Javier De Gaudenzi, Deborah E. Dobson, Andreas Duesterhoeft, Gholam Fazelina, Nigel Fosker, Alberto Carlos Frasch, Audrey Fraser, Monika Fuchs, Claudia Gabel, Arlette Goble, André Goffeau, David Harris, Christiane Hertz-Fowler, Helmut Hilbert, David Horn, Yiting Huang, Sven Klages, Andrew Knights, Michael Kube, Natasha Larke, Lyudmila Litvin, Angela Lord, Tin Louie, Marco Marra, David Masuy, Keith Matthews, Shulamit Michaeli, Jeremy C. Mottram, Silke Müller-Auer, Heather Munden, Siri Nelson, Halina Norbertczak, Karen Oliver, Susan O'Neil, Martin Pentony, Thomas M. Pohl, Claire Price, Bénédicte Purnelle, Michael A. Quail, Ester Rabbinowitsch, Richard Reinhardt, Michael Rieger, Joel Rinta, Johan Robben, Laura Robertson, Jeronimo C. Ruiz, Simon Rutter, David Saunders, Melanie Schäfer, Jacquie Schein, David C. Schwartz, Kathy Seeger, Amber Seyler, Sarah Sharp, Heesun Shin, Dhileep Sivam, Rob Squares, Steve Squares, Valentina Tosato, Christy Vogt, Guido Volckaert, Rolf Wambutt, Tim Warren, Holger Wedler, John Woodward, Shiguo Zhou, Wolfgang Zimmermann, Deborah F. Smith, Jenefer M. Blackwell, Kenneth D. Stuart, Bart Barrell, and Peter J. Myler
Science 15 July 2005: 436-442.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

This Week in Science

Editor summaries of this week's papers.
Science 15 July 2005: 351.
|Full Text »

Editorial:
Trypanosomes at the Gates

George A. M. Cross
Science 15 July 2005: 355.
Summary »|   PDF »|  

Editors' Choice

Highlights of the recent literature.
Science 15 July 2005: 357.
|Full Text »

NetWatch

Best of the Web in science.
Science 15 July 2005: 361.
|Full Text »

New Products

Science 15 July 2005: 495.
Summary »|   PDF »|  

News of the Week

ENVIRONMENTAL HEALTH:
Lead Paint Experts Face a Barrage of Subpoenas

Jocelyn Kaiser
Science 15 July 2005: 362-363.
Summary »|   Full Text »|   PDF »|  

CLIMATE CHANGE:
G8 Leaders Make a Promise to Do More

Eliot Marshall
Science 15 July 2005: 362.
Summary »|   Full Text »|   PDF »|  

ASTRONOMY:
Improved X-ray Telescope Takes Flight

Dennis Normile
Science 15 July 2005: 363.
Summary »|   Full Text »|   PDF »|  

GEOPHYSICS:
Threshold Crossed on the Way to a Geodynamo in a Computer

Richard A. Kerr
Science 15 July 2005: 364-365.
Summary »|   Full Text »|   PDF »|  

AVIAN INFLUENZA:
Chinese Ministry Questions Bird Flu Findings

Dennis Normile
Science 15 July 2005: 364.
Summary »|   Full Text »|   PDF »|  

CLIMATE FORECASTING:
India Chucks Monsoon Model

Pallava Bagla
Science 15 July 2005: 365.
Summary »|   Full Text »|   PDF »|  

ENERGY SCIENCE:
Tight Budgets Force Lab Layoffs

Eli Kintisch
Science 15 July 2005: 366-367.
Summary »|   Full Text »|   PDF »|  

NONLINEAR OPTICS:
To Physicists' Surprise, a Light Touch Sets Tiny Objects Aquiver

Adrian Cho
Science 15 July 2005: 366.
Summary »|   Full Text »|   PDF »|  

RESEARCH MANAGEMENT:
NSF Looks Inward for Geoscience Head

Jeffrey Mervis
Science 15 July 2005: 367.
Summary »|   Full Text »|   PDF »|  

ScienceScope

Science 15 July 2005: 365.
|Full Text »

Random Samples

Science 15 July 2005: 378.
|Full Text »

News Focus

AVIAN INFLUENZA:
Vietnam Battles Bird Flu ... and Critics

Dennis Normile
Science 15 July 2005: 368-373.
Summary »|   Full Text »|   PDF »|  

AVIAN INFLUENZA:
Pandemic Influenza: Global Update

Martin Enserink
Science 15 July 2005: 370-371.
Summary »|   PDF »|  

AVIAN INFLUENZA:
Who Controls the Samples?

Dennis Normile
Science 15 July 2005: 372-373.
Summary »|   Full Text »|   PDF »|  

EVOLUTION 2005 MEETING:
Fungal Trees Grow Faster With Computer Help

Elizabeth Pennisi
Science 15 July 2005: 374.
Summary »|   Full Text »|   PDF »|  

EVOLUTION 2005 MEETING:
Color Genes Help Mice and Lizards

Elizabeth Pennisi
Science 15 July 2005: 374-375.
Summary »|   Full Text »|   PDF »|  

EVOLUTION 2005 MEETING:
Wine Yeast's Surprising Diversity

Elizabeth Pennisi
Science 15 July 2005: 375-376.
Summary »|   Full Text »|   PDF »|  

NANOMATERIALS:
'Smart Coatings' Research Shows The Virtues of Superficiality

John Bohannon
Science 15 July 2005: 376-377.
Summary »|   Full Text »|   PDF »|  

Letters

This Week's Letters

Science 15 July 2005: 380.
Summary »|   PDF »|  

 Chronic Versus Acute Diseases

Abiola C. Senok, Giuseppe A. Botta;, Derek Yach, Steve Leeder, and John Bell
Science 15 July 2005: 380-381.
Full Text »|   PDF »|  

 Domesticated Pigs in Eastern Indonesia

Peter Bellwood, Peter White;, Greger Larson, Keith Dobney, Umberto Albarella, Elizabeth Matisoo-Smith, Judith Robins, Stewart Lowden, Peter Rowley-Conwy, Leif Andersson, and Alan Cooper
Science 15 July 2005: 381.
Full Text »|   PDF »|  

 Mechanism of JCV Entry into Oligodendrocytes

Sandro Santagata, Hannah C. Kinney;, and Walter J. Atwood
Science 15 July 2005: 381-382.
Full Text »|   PDF »|  

Books et al.

HISTORY OF SCIENCE:
Science as Comic Metaphysics

Susan Lindee
Science 15 July 2005: 383-384.
Summary »|   Full Text »|   PDF »|  

SCIENCE AND SOCIETY:
Deconstructing Biotechnology

Juan Enriquez
Science 15 July 2005: 384.
Summary »|   Full Text »|   PDF »|  

Books Received

Science 15 July 2005: 384.
Summary »|  

Policy Forum

ETHICS:
Moral Issues of Human-Non-Human Primate Neural Grafting

Mark Greene, Kathryn Schill, Shoji Takahashi, Alison Bateman-House, Tom Beauchamp, Hilary Bok, Dorothy Cheney, Joseph Coyle, Terrence Deacon, Daniel Dennett, Peter Donovan, Owen Flanagan, Steven Goldman, Henry Greely, Lee Martin, Earl Miller, Dawn Mueller, Andrew Siegel, Davor Solter, John Gearhart, Guy McKhann, and Ruth Faden
Science 15 July 2005: 385-386.
Summary »|   Full Text »|   PDF »|   Supporting Online Material »|  

Perspectives

NEUROSCIENCE:
Monte Carlo Places Strong Odds on Ectopic Release

Vladan Lucic and Wolfgang Baumeister
Science 15 July 2005: 387-388.
Summary »|   Full Text »|   PDF »|  

APPLIED PHYSICS:
Where Do the Dopants Go?

Scott Roy and Asen Asenov
Science 15 July 2005: 388-390.
Summary »|   Full Text »|   PDF »|  

ASTRONOMY:
The First Generations of Stars

Timothy C. Beers
Science 15 July 2005: 390-391.
Summary »|   Full Text »|   PDF »|  

MATERIALS SCIENCE:
The Renaissance of Magnetoelectric Multiferroics

Nicola A. Spaldin and Manfred Fiebig
Science 15 July 2005: 391-392.
Summary »|   Full Text »|   PDF »|  

NEUROSCIENCE:
Brain Under Surveillance: The Microglia Patrol

Luc Fetler and Sebastian Amigorena
Science 15 July 2005: 392-393.
Summary »|   Full Text »|   PDF »|  

Brevia

Arctic Seabirds Transport Marine-Derived Contaminants

Jules M. Blais, Lynda E. Kimpe, Dominique McMahon, Bronwyn E. Keatley, Mark L. Mallory, Marianne S. V. Douglas, and John P. Smol
Science 15 July 2005: 445.
Pollutants such as DDT and mercury ultimately find their way to Arctic ponds through deposition of contaminated guano by seabirds. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Article

Evidence for Ectopic Neurotransmission at a Neuronal Synapse

Jay S. Coggan, Thomas M. Bartol, Eduardo Esquenazi, Joel R. Stiles, Stephan Lamont, Maryann E. Martone, Darwin K. Berg, Mark H. Ellisman, and Terrence J. Sejnowski
Science 15 July 2005: 446-451.
Monte Carlo simulations model a synapse and its surroundings, predicting that transmitter release occurs outside the synapse itself. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

The First Chemical Enrichment in the Universe and the Formation of Hyper Metal-Poor Stars

Nobuyuki Iwamoto, Hideyuki Umeda, Nozomu Tominaga, Ken'ichi Nomoto, and Keiichi Maeda
Science 15 July 2005: 451-453.
Published online 2 June 2005 [DOI: 10.1126/science.1112997] (in Science Express Reports)
A computer model of star evolution shows that stars containing very little metal are not a primitive class but instead formed from the debris of older supernovae. Abstract »|   Full Text »|   PDF »|  

Controlled Single-Photon Emission from a Single Trapped Two-Level Atom

B. Darquié, M. P. A. Jones, J. Dingjan, J. Beugnon, S. Bergamini, Y. Sortais, G. Messin, A. Browaeys, and P. Grangier
Science 15 July 2005: 454-456.
Excitation of a single, optically trapped rubidium atom provides an on-demand source of identical single photons. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Structural Relaxation of Polymer Glasses at Surfaces, Interfaces, and In Between

Rodney D. Priestley, Christopher J. Ellison, Linda J. Broadbelt, and John M. Torkelson
Science 15 July 2005: 456-459.
Glassy polymers show greatly reduced physical aging near surfaces and interfaces, probably altering their long-term behavior in thin films. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Simulations of a Quasi–Taylor State Geomagnetic Field Including Polarity Reversals on the Earth Simulator

Futoshi Takahashi, Masaki Matsushima, and Yoshimori Honkura
Science 15 July 2005: 459-461.
A model of convection in Earth's liquid outer core successfully simulates the lack of axial magnetic torque and produces reversals in the magnetic pole. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Earthquake Source Fault Beneath Tokyo

Hiroshi Sato, Naoshi Hirata, Kazuki Koketsu, David Okaya, Susumu Abe, Reiji Kobayashi, Makoto Matsubara, Takaya Iwasaki, Tanio Ito, Takeshi Ikawa, Taku Kawanaka, Keiji Kasahara, and Steven Harder
Science 15 July 2005: 462-464.
The major plate boundary fault that underlies Tokyo is at a much shallower depth than has been thought, portending a much greater seismic hazard. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Heat Flux Anomalies in Antarctica Revealed by Satellite Magnetic Data

Cathrine Fox Maule, Michael E. Purucker, Nils Olsen, and Klaus Mosegaard
Science 15 July 2005: 464-467.
Published online 9 June 2005 [DOI: 10.1126/science.1106888] (in Science Express Reports)
Satellite magnetic data map the geothermal heat flux beneath the Antarctic ice sheet and show that heat flow is high beneath some ice streams and may threaten stability. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

RNA Polymerase II Is Required for RNAi-Dependent Heterochromatin Assembly

Hiroaki Kato, Derek B. Goto, Robert A. Martienssen, Takeshi Urano, Koichi Furukawa, and Yota Murakami
Science 15 July 2005: 467-469.
Published online 9 June 2005 [DOI: 10.1126/science.1114955] (in Science Express Reports)
RNA polymerase II is required for silencing the chromosome regions around the centromere of fission yeast, a process directed by small RNAs transcribed from this region. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Apolipoprotein L-I Promotes Trypanosome Lysis by Forming Pores in Lysosomal Membranes

David Pérez-Morga, Benoit Vanhollebeke, Françoise Paturiaux-Hanocq, Derek P. Nolan, Laurence Lins, Fabrice Homblé, Luc Vanhamme, Patricia Tebabi, Annette Pays, Philippe Poelvoorde, Alain Jacquet, Robert Brasseur, and Etienne Pays
Science 15 July 2005: 469-472.
A protein in human blood kills African trypanosomes by forming pores in the membrane of the parasite's lysosomes. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Trypanosoma cruzi Proteome

J. A. Atwood, III, D. B. Weatherly, T. A. Minning, B. Bundy, C. Cavola, F. R. Opperdoes, R. Orlando, and R. L. Tarleton
Science 15 July 2005: 473-476.
Proteome analysis of T. cruzi,which causes Chagas' disease, indicates that the individual stages of the parasite rely on different sources of energy. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

K. SantaCruz, J. Lewis, T. Spires, J. Paulson, L. Kotilinek, M. Ingelsson, A. Guimaraes, M. DeTure, M. Ramsden, E. McGowan, C. Forster, M. Yue, J. Orne, C. Janus, A. Mariash, M. Kuskowski, B. Hyman, M. Hutton, and K. H. Ashe
Science 15 July 2005: 476-481.
The cognitive decline seen in mice overexpressing a neurodegeneration-associated protein can be reversed by suppression of the transgene. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

G. C. Kujoth, A. Hiona, T. D. Pugh, S. Someya, K. Panzer, S. E. Wohlgemuth, T. Hofer, A. Y. Seo, R. Sullivan, W. A. Jobling, J. D. Morrow, H. Van Remmen, J. M. Sedivy, T. Yamasoba, M. Tanokura, R. Weindruch, C. Leeuwenburgh, and T. A. Prolla
Science 15 July 2005: 481-484.
Mitochondrial mutations, which accumulate with age, increase the propensity of cells to undergo apoptosis. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Chromatic Adaptation of Photosynthetic Membranes

Simon Scheuring and James N. Sturgis
Science 15 July 2005: 484-487.
Proteins in photosynthetic membranes assemble in paracrystalline, light-harvesting domains that enlarge at low light levels. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Shared Cortical Anatomy for Motor Awareness and Motor Control

A. Berti, G. Bottini, M. Gandola, L. Pia, N. Smania, A. Stracciari, I. Castiglioni, G. Vallar, and E. Paulesu
Science 15 July 2005: 488-491.
Patients unaware of their limb paralysis have lesions in movement-related brain areas, suggesting that the neural substrate for awareness overlaps that for movement. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Distinct Kinetic Changes in Neurotransmitter Release After SNARE Protein Cleavage

Takeshi Sakaba, Alexander Stein, Reinhard Jahn, and Erwin Neher
Science 15 July 2005: 491-494.
Toxins that cleave three different subunits of the vesicular fusion machinery reveal the detailed kinetics of synaptic vesicle release. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|